Citryl-imine-PEG-ylated chitosan hydrogels – Promising materials for drug delivery applications

Ailincai, Daniela; Mititelu-Tarțău, Liliana; Marin, Luminița

doi:10.1016/j.ijbiomac.2020.06.218

Cited by 26 publications

(24 citation statements)

References 52 publications

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“…The in vitro release kinetic was monitored by batch experiment performed in phosphate buffer saline (PBS) (pH=7.4), at the human body temperature (37 o C), following a previously used experimental procedure, which mainly consisted in the determination of the percent of released drug at different moments [9,17]. The experiments were done in triplicate and the values were given as the mean value of three independent measurements.…”

Section: Methodsmentioning

confidence: 99%

“…Formulations were prepared by in situ hydrogelation of PEGylated chitosan with citral in the presence of diclofenac sodium salt, following a receipt already published [9]. Shortly, two hydrophilic PEGylated chitosan derivatives with different content of PEG were reacted with hydrophobic citral in the presence of model drug, at 55 o C, under vigorous magnetic stirring.…”

Section: Synthesis Of the Drug Delivery Systemsmentioning

confidence: 99%

“…nausea, vomiting, diarrhea, or even hepatotoxicity [6][7][8][9][10][11][12]. This is due to the polycationic nature of chitosan which favors a strong anchoring of the drug molecules by Coulomb forces, and also by formation of H-bonds with the hydroxyl groups [7][8][9][10]. The development of such interfacial forces competes with the hydrogen bonds developed between the drug molecules and water solvent, assuring a slow release.…”

Section: Introductionmentioning

confidence: 99%

“…The main drawback of the use of chitosan for drug delivery systems is its low solubility at the physiological pH [13]. A route to overcome this disadvantage is the grafting of water soluble poly(ethylene glycol) (PEG) chains on the chitosan backbones, by obtaining PEGylated chitosan [9].…”

Section: Introductionmentioning

confidence: 99%

“…Replacing chitosan with PEGylated chitosan in view of the development of matrixes for controlled drug release, not only suppresses the disadvantage of the chitosan hydrophobicity in neutral or basic pH media, but also creates an important tool towards the control of the drug release rate by simple control of the hydrophobic/hydrophilic balance [9,14]. In this line of thoughts, an amphiphilic matrix based on chitosan was prepared and also its ability to release a model drug in controlled manner was investigated [9]. It was demonstrated that the degree of substitution of the chitosan backbones with PEG chains tune the drug release rate by the dissolution rate.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Himiniuc¹,

Agop²,

Ghizdovăţ³

et al. 2021

Mater. Plast.

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Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient s comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gynecology have been discussed.

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of the Drug Delivery Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Himiniuc¹,

Agop²,

Ghizdovăţ³

et al. 2021

Mater. Plast.

View full text Add to dashboard Cite

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Development of cress seed gum hydrogel and investigation of its potential application in the delivery of curcumin

Shahbazizadeh¹,

Naji‐Tabasi²,

Shahidi‐Noghabi³

et al. 2021

J Sci Food Agric

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BACKGROUND: Bioactive compound delivery systems must provide stability against severe food processing and environmental conditions. Cress seed gum (CSG) with high thermal stability can be a promising polysaccharide for preparing physically crosslinked hydrogel as a curcumin delivery system. In the present study, CSG (0.05, 0.10 and 0.15 g kg −1 ) and calcium chloride (CaCl 2 ) (0.00, 0.02, 0.04, 0.06 and 0.10 g kg −1 ) solutions were used for hydrogel fabrication.RESULTS: Physicochemical properties of hydrogels were evaluated by entrapment efficiency, loading capacity and swelling degree, differential scanning calorimetry, scanning electron microscopy, in vitro release and free radical scavenging capacity assessments. Accordingly, 0.15 g kg −1 CSG-0.02 g kg −1 CaCl 2 hydrogel was revealed to have high entrapment efficiency (93.6 ± 1.59%), loading capacity (0.92 ± 0.00%) and swelling degree (105.96 ± 12.99%), as well as heat stability above 103 °C. CSG hydrogel significantly (P < 0.05) protected the antioxidant activity of curcumin against thermal process. The curcumin release in the acidic stomach medium was negligible, although it increased significantly in the simulated intestinal environment (42.5 ± 0.75%), which followed the Peppas model. CONCLUSION: As a result, CSG hydrogel can protect curcumin during food thermal processing and digestion time. Therefore, CSG hydrogel can play a valued role in modern-day food formulations with an increasing consumer preference for plantderived materials.

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Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems

Xia,

Ma,

et al. 2023

Macromolecular Bioscience

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Sustainable and controllable drug transport is one of the most efficient ways of disease treatment. Due to high biocompatibility, good biodegradability, and low costs, chitosan and its derivatives are widely used in biomedical fields. Specifically, chitosan hydrogel enables drugs to pass through biological barriers because of their abundant amino and hydroxyl groups that can interact with human tissues. Moreover, the multi‐responsive nature (pH, temperature, ions strength, and magnetic field, etc.) of chitosan hydrogels makes precise drug release a possibility. Here, the synthesis methods, modification strategies, stimuli‐responsive mechanisms of chitosan‐based hydrogels, and their recent progress in drug delivery are summarized. Chitosan hydrogels that carry and release drugs through subcutaneous (dealing with wound dressing), oral (dealing with gastrointestinal tract), and facial (dealing with ophthalmic, ear, and brain) are reviewed. Finally, challenges toward clinic application and the future prospects of stimuli‐responsive chitosan‐based hydrogels are indicated.

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Citryl-imine-PEG-ylated chitosan hydrogels – Promising materials for drug delivery applications

Cited by 26 publications

References 52 publications

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Development of cress seed gum hydrogel and investigation of its potential application in the delivery of curcumin

Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems

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