Citrullination in periodontium is associated with Porphyromonas gingivalis

Maldonado, Alejandra; Pirracchio, Luca; Imber, Jean‐Claude; Bürgin, Walter; Möller, Burkhard; Sculean, Anton; Eick, Sigrun

doi:10.1016/j.archoralbio.2020.104695

Cited by 15 publications

(9 citation statements)

References 58 publications

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“…; Sc, Streptococcus constellatus. References: [A] : Cardoso et al ( 2018 ); [B] : Bui et al ( 2019 ), [C] : Fine et al ( 2020 ), [D] : Gallimidi et al ( 2015 ), [E] : Ha et al ( 2015 ), [F] : Lamster and Pagan ( 2017 ), [G] : Jepsen et al ( 2020 ), [H] : Minty et al ( 2019 ), [I] : Torrungruang et al ( 2018 ), [J] : Suh et al ( 2019 ), [K] : Schenkein et al ( 2020 ), [L] : Singhal et al ( 2016 ), [M] : Cecoro et al ( 2020 ), [N] : Baeza et al ( 2020 ), [O] : Furutama et al ( 2020 ), [P] : Ferguson et al ( 2020 ) [Q] : Preshaw et al ( 2020 ), [R] : Sukumar and Tadepalli ( 2021 ), [S] : Badran et al ( 2020 ), [T] : Coke et al ( 2021 ), [U] : Han and Wang ( 2013 ), [V] : González-Febles and Sanz ( 2021 ), [W] : Maldonado et al ( 2020 ), [X] : Bunte and Beikler ( 2019 ), [Y] : Poole et al ( 2013 ), [Z] : Poole et al ( 2015 ), [Aa] : Stein et al ( 2012 ), [Ab] : Bobetsis et al ( 2020 ) .…”

Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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“…Whereas previous studies classically investigated putative association mechanisms between periodontal taxa and the presence of ACPAs, the current report examined correlations with RFs 12,38 . RFs are a family of autoantibodies directed against the Fc fragment of IgG's 39 .…”

Section: Discussionmentioning

confidence: 98%

“…37 Whereas previous studies classically investigated putative association mechanisms between periodontal taxa and the presence of ACPAs, the current report examined correlations with RFs. 12,38 RFs are a family of autoantibodies directed against the Fc fragment of IgG's. 39 Detection of high titers and high affinity RFs in established RA represents a recognized severity factor associated with extra-articular manifestations, which is not the case for ACPAs.…”

Section: Discussionmentioning

confidence: 99%

Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis

Manoil

Bostancı

Mumcu

et al. 2020

Journal of Periodontology

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Background: Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential correlations between detached subgingival bacteria collected in gingival crevicular fluid (GCF) and RA parameters. Methods: RA patients (n = 52, F:M = 40:12), patients with Behcet's disease (BD, n = 40, F:M = 29:11) as another systemic inflammatory disease were studied along with a systemically healthy control group (HC, n = 57, F:M = 40:17). All participants were non-smokers. Full mouth periodontal parameters were recorded. RA activity was assessed using the 28-joint Disease Activity Score (DAS-28). Rheumatoid factors (RFs)-IgM and-IgA were measured by ELISA. GCF samples were investigated by means of fluorescent in situ hybridization for 10 different bacterial taxa. Results: The taxa TM7, Synergistetes cluster B, Leptotrichia, Megasphaera, Anaeroglobus geminatus, and Tannerella forsythia displayed significantly differential abundances between the groups. Whereas abundances of Megasphaera and A. geminatus were significantly increased in the RA group, only Porphyromonas gingivalis displayed significant correlations with plaque scores, bleeding on probing, and RF-IgA. RA patients displaying RF-IgA levels >75 IU/mL exhibited five-fold more abundant P. gingivalis levels than patients below the threshold. This association with RF-IgA levels appeared even more pronounced, by six-fold more P. gingivalis (P = 0.025), in patients with a DAS-28 score >3.2, indicative of moderate/very active RA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Anti‐inflammatory cytokines IL‐4 and IL‐10 have been shown to be lower, or the same, in GCF in RA patients and periodontitis patients than in periodontally healthy controls 18,25 . Maldonado et al showed that MCP‐1 and IL‐17 were elevated and IL‐10 reduced in GCF in RA patients 26 …”

Section: Discussionmentioning

confidence: 99%

“… 18 , 25 Maldonado et al showed that MCP‐1 and IL‐17 were elevated and IL‐10 reduced in GCF in RA patients. 26 …”

Section: Discussionmentioning

confidence: 99%

Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population‐based cross‐sectional study: RANTES was associated with periodontitis

Söderlin

Persson

Renvert

et al. 2021

J of Periodontal Research

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Objective We studied cytokines in gingival crevicular fluid (GCF) in a cross‐sectional population‐based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods In a population‐based cross‐sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1‐β (IL‐1β), IL‐4, IL‐6, IL‐10, IL‐17A, tumor necrosis factor alpha (TNF‐α), interferon gamma (IFN‐γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP‐1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti‐cyclic citrullinated protein (anti‐CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti‐rheumatic medication, disease duration and the cytokine in question. Results Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p = .049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion In this population‐based elderly RA cohort, neither pro‐inflammatory nor anti‐inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.

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Citrullination in periodontium is associated with Porphyromonas gingivalis

Cited by 15 publications

References 58 publications

Periodontal Inflammation and Systemic Diseases: An Overview

Periodontal Inflammation and Systemic Diseases: An Overview

Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis

Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population‐based cross‐sectional study: RANTES was associated with periodontitis

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