Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population‐based cross‐sectional study: RANTES was associated with periodontitis

Abstract

Objective We studied cytokines in gingival crevicular fluid (GCF) in a cross‐sectional population‐based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods In a population‐based cross‐sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1‐β (IL‐1β), IL‐4, IL‐6, IL‐10, IL‐17A, tumor necrosis factor alpha (TNF‐α), interferon gamma (IFN‐γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP‐1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti‐cyclic citrullinated protein (anti‐CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti‐rheumatic medication, disease duration and the cytokine in question. Results Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p = .049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion In this population‐based elderly RA cohort, neither pro‐inflammatory nor anti‐inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.

Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis

“…With an increase in human life expectancy, the population of ERA expands significantly. ERA patients have clinical and biological characteristics totally different from the young counterparts [ 21 ]. Some scholars believe that the fail treat-to-target in ERA is related to the lack of proactive clinical treatment, while at the same, RA treatment guidelines or expert opinion emphasize that biological agents do not increase the adverse events in the ERA population [ 22 , 23 ].…”

Workforce situation of the Chinese mental health care system: results from a cross-sectional study

“…Variance Inflation Factor (VIF) values larger than 10 were regarded as having the presence of multicollinearity [24], and in our study, the VIF values of all independent variables were < 10. We measured Kendall's tau-b correlation analysis among training situations and competency and further performed multiple linear regression analysis with competence in psychological counseling or psychotherapy using age, gender, hospital levels, education level, workforce types, titles, specialty and psychological training situations as predictive factors [26]. The dependent variable was competence in psychological counseling or psychotherapy.…”

Antibodies against Porphyromonas gingivalis in serum and saliva and their association with rheumatoid arthritis and periodontitis. Data from two rheumatoid arthritis cohorts in Sweden

“…The Karlskrona RA study has been described in detail in previous studies ( 14 , 15 , 17 ). Briefly, between October 2013 and January 2015, all individuals with a clinical diagnosis of RA (M05 and M06, ICD-10) ≥ 61 years of age living in Karlskrona city in Southern Sweden were identified from the electronic regional database (Region Blekinge, Sweden).…”