Citric acid crosslinked cyclodextrin/hydroxypropylmethylcellulose hydrogel films for hydrophobic drug delivery

Ghorpade, Vishwajeet Sampatrao; Yadav, Adhikrao Vyankatrao; Dias, Remeth J.

doi:10.1016/j.ijbiomac.2016.08.072

Cited by 97 publications

(53 citation statements)

References 44 publications

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“…The ATR-FTIR spectrum of hydrogel film showed additional peaks at 1710 to 1730 cm -1 attributed to the carbonyl band of free carboxylic acid groups and the carbonyl band of ester formed during the TG-CMC, CMC-CMC and TG-TG crosslinking. To confirm the formation of ester linkages further, hydrogel film was treated with 0.1 N NaOH in [31] . Solid-state 13 C NMR spectrum of TG showed three distinct peaks ( fig.…”

Section: Resultsmentioning

confidence: 99%

“…to determine the release mechanism [31,48] . M t /M ∞ = at n , where the fraction of drug released in time 't', 'a' is the kinetic constant and 'n' is the diffusional coefficient, which depended upon the interaction in between drug and the components of hydrogel matrix.…”

Section: Resultsmentioning

confidence: 99%

“…Then, the hydrogel films were dried in a hot air oven at 50° for 24 h and stored in a desiccator until use. The parameters such as concentrations of TG, CMC, citric acid and curing time were varied individually to study their effect on hydrogel properties [31] .…”

Section: Preparation Of Citric Acid Crosslinked Tg-based Hydrogel Filmsmentioning

confidence: 99%

“…Positive and negative controls were obtained by adding 0.5 ml of human CPD blood and saline, respectively, to 4.0 ml of double-distilled water. The incubated samples were centrifuged for 10 min at 3500 rpm, the supernatant was taken, and its absorbance was measured on a spectrophotometer at 545 nm [31] . Percent haemolysis was calculated using the following relationship: haemolysis (%) = (A Test sample -A -ve control )/ (A +ve control -A -ve control )×100, where, A is the absorbance.…”

Section: Haemolysis Assaymentioning

confidence: 99%

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Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

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Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Citric Acid Crosslinked Tg-based Hydrogel Filmsmentioning

confidence: 99%

Section: Haemolysis Assaymentioning

confidence: 99%

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Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

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“…Hydrogel dressings were prepared using previously reported method with slight modification. [28,29] In brief, 2% w/v aqueous solutions of the TG and CMC were prepared. Initially, TG was added to the water and stirred using mechanical stirrer (RQG126D, Remi, India) at room temperature.…”

Section: Preparation Of Citric Acid Cross-linked Polysaccharide-basedmentioning

confidence: 99%

Untitled

Mali¹

2018

AJP

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Aim: The objective of this study was to develop and evaluate carboxymethylcellulose (CMC) and tamarind gum (TG)-based citric acid cross-linked vancomycin-loaded hydrogel dressing for wound healing. Materials and Methods: CMC and TG are known for its biocompatibility and biodegradability and hence selected for preparation of hydrogel dressings. The hydrogel films were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid-state 13 C-nuclear magnetic resonance (13 C-NMR) spectroscopy, differential scanning calorimeter (DSC), and scanning electron microscopy (SEM). The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Vancomycin hydrochloride was loaded into hydrogels films and drug release was studied in the phosphate buffer pH 7.4. The hemolysis assay was used to study the biocompatibility of hydrogel films. The wound healing activity of optimized hydrogel film was studied in the albino mice of either sex. Results and Discussion: The results of ATR-FTIR, solid-state 13 C-NMR, DSC, and SEM confirmed the formation of citric acid cross-linked hydrogel films. The total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of cross-linker was increased. The prepared hydrogel dressing showed pH-dependent swelling and swelling was decreased significantly with increase in the concentration of TG and cross-linker. Optimized hydrogel dressing batch HD1 exhibited highest drug loading with non-Fickian drug release. Hydrogel dressings were found to be hemocompatible and exhibited wound healing activity in mice. Conclusion: It can be concluded that the citric acid cross-linked polysaccharide-based hydrogel dressings have potential application in the development of topical drug delivery systems for treatment of the wound.

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Fabrication of citric acid crosslinked β‐cyclodextrin/hydroxyethylcellulose hydrogel films for controlled delivery of poorly soluble drugs

Ghorpade

Yadav

Dias

et al. 2018

J of Applied Polymer Sci

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β‐cyclodextrin grafted hydroxyethylcellulose (βCD‐g‐HEC) hydrogel films were prepared for the controlled release of poorly soluble model drug (ketoconazole) using citric acid as crosslinking agent. The active βCD and carboxyl content of the hydrogel films were determined by phenolphthalein assay and acid–base titration. The films were characterized by solid state 13C NMR, ATR–FTIR, thermogravimetric analysis, and differential scanning calorimetric, and analyzed for tensile strength, swelling ratio, drug loading, release, hemocompatibility, in vitro cytotoxicity, and implantation test. An increase in the concentration of βCD in feed increased the active βCD content of the hydrogel films but reduced their extent of interpolymer crosslinking. The βCD‐g‐HEC hydrogel films with high active βCD content showed maximum drug loading whereas those with high crosslinking density were capable of controlling the drug release for long duration. Hemolysis assay and in vitro cytotoxicity study revealed the biocompatible nature of the hydrogel films whereas implantation test indicated their minimal inflammatory effect. From the overall results, βCD‐g‐HEC hydrogel films were found to be better alternative to the previously reported βCD‐HPMC and βCD‐CMC hydrogel films for enhanced loading and long‐term release, respectively, of the poorly soluble drugs. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46452.

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Citric acid crosslinked cyclodextrin/hydroxypropylmethylcellulose hydrogel films for hydrophobic drug delivery

Cited by 97 publications

References 44 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Untitled

Fabrication of citric acid crosslinked β‐cyclodextrin/hydroxyethylcellulose hydrogel films for controlled delivery of poorly soluble drugs

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