Citicoline and Eye Health

Grieb, Paweł

doi:10.1016/b978-0-12-815245-4.00035-1

Cited by 3 publications

(2 citation statements)

References 91 publications

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“…(citicoline or CDPcholine) [9], There are two variants of the same substance covered by the name "citicoline." First, "citicoline sodium," which is traditionally considered a pharmaceutical substance, which, in the Anatomical Therapeutic Chemical classification of drugs (ATC).The second one, "citicoline inner salt" (or "citicoline free base"), is Formally considered as a food ingredient (since 2009 2) in United States and in the European Union(since2013 3) [10]. Citicoline has shown beneficial effects in several CNS injury models, neurodegenerative diseases, ophthalmology, and psychiatry.…”

Section: Cytidine-5′-diphosphocholinementioning

confidence: 99%

Piracetam And Citicoline Effect on The General Anesthesia Animals Model

2022

pnr

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The brain is the target organ for both general anesthetic drugs and some drugs that are used to treat nervous disorders which cause brain activation such as piracetam and citicoline however, they work in contrast to each other.Objective: Our study set out to determine the effect of piracetam and citicoline on the anesthetic induction time.Method: For 10 days 24 mice had been treated with piracetam and citicoline in three groups (piracetam group, citicoline group, and mix group). In addition, 7 mice were used as a control group. All mice were assessed with open field test and underwent right reflex and pain reflex tests.Results: The statistical results showed there is a highly significant relationship between the groups that received drugs in comparison to the control group during assessment by open field test (during the first three sequences) with P-value (0.000, 0.039, 0.008), also a non-significant association relationship between the right reflex test and the drug (piracetam with citicoline). On the other hand, there was a highly significant association relationship between the pain reflex test and the drug (piracetam with citicoline) with P-value(0.009).Conclusion: the time required to achieve the surgical anesthesia stage had been delayed by the influence of piracetam and citicoline use.

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Section: Cytidine-5′-diphosphocholinementioning

confidence: 99%

Piracetam And Citicoline Effect on The General Anesthesia Animals Model

2022

pnr

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“…In this context, it is certainly worth to mention that the principal application of VEP recordings is for diagnostics and therapy monitoring of primary open angle glaucoma (POAG), an ophthalmic condition currently considered a neurodegenerative disease [ 51 ]. In POAG patients, citicoline treatment, parenteral as well as oral, has been repeatedly shown to increase amplitude and decrease latency of VEPs [ 52 , 53 , 54 ]. Moreover, in POAG patients, oral citicoline treatment halted the decrease in retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC), their thickness monitored by optical coherence tomography (OCT) [ 55 ].…”

Section: Citicoline Should Be Evaluated In Msmentioning

confidence: 99%

Citicoline: A Candidate for Adjunct Treatment of Multiple Sclerosis

et al. 2021

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In remitting–relapsing multiple sclerosis (RR-MS), relapses are driven by autoreactive immune cells that enter the brain and spinal cord and damage myelin sheaths of axons in white and grey matter, whereas during remissions myelin is repaired by activated oligodendroglial cells. Disease-modifying therapies (DMTs) may either retard/attenuate myelin damage or promote/enhance/speed up myelin repair. Almost all currently approved DMTs inhibit myelin damage and are considerably toxic. Enhancement of myelin repair is considered an unmet medical need of MS patients. Citicoline, known for many years as a nootropic and neuroprotective drug and recently pronounced food supplement, has been found to be significantly efficacious in two complementary rodent models of MS, experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced myelin toxicity. Moreover, citicoline treatment improves visual evoked potentials (VEPs) in glaucoma patients, which is relevant because VEP monitoring is frequently used as an indicator of remyelination in MS. Although over-the-counter availability of citicoline may impede its formal translation to the clinic of MS, evaluation of its efficacy for supporting remyelination in this disease is strongly indicated.

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Effectiveness of citicoline in pediatric patients with refractive amblyopia in Surabaya, East Java, Indonesia

Loebis

Zulkarnain

Siswanto

2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Amblyopia is a decrease of visual acuity that cannot be attributed to any structural abnormality of the eye or visual system, causing a partial or complete loss of vision due to inadequate stimulation in early life. Citicoline has been reported to improve visual acuity in amblyopic eyes as adjuvant treatment. This study was aimed to determine the effectiveness of citicoline in pediatric patients with refractive amblyopia in ophthalmology daily practices. Methods This was a retrospective–descriptive study with a time limited sampling method. This study was conducted at Surabaya Eye Clinic, East Java, Indonesia, by reviewing medical records for the period of January 2018 to December 2019. Results A total of 34 eyes were included in the study with the majority aged five years (41.2%) and six years (35.3%). The severity of amblyopia varied among patients, 21 eyes (61.76%) had mild amblyopia, seven eyes (20.59%) had moderate amblyopia, and two eyes (5.88%) had severe amblyopia. The duration of given therapy also varied, 18 eyes (52.94%) were given 3 months therapy, two eyes were given 4 months therapy, 12 eyes were given 6 months therapy, and two eyes were given 8 months therapy. Citicoline was found effective in mild and moderate amblyopia and for the duration of 3 and 6 months (p<0.05). In others group who did not showed statistically significant improvement was due to inadequate samples but clinically significant improvement was noted. Conclusions Citicoline therapy resulted in a clinically and statistically improvement in refractive amblyopia patients.

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Citicoline and Eye Health

Cited by 3 publications

References 91 publications

Piracetam And Citicoline Effect on The General Anesthesia Animals Model

Piracetam And Citicoline Effect on The General Anesthesia Animals Model

Citicoline: A Candidate for Adjunct Treatment of Multiple Sclerosis

Effectiveness of citicoline in pediatric patients with refractive amblyopia in Surabaya, East Java, Indonesia

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