Cisterna magna width at 11–13 weeks in the detection of posterior fossa anomalies

García-Posada, Raúl Alejandro; Eixarch, Elisenda; Sanz, María; Puerto, B.; Figueras, F.; Borrell, Antoni

doi:10.1002/uog.12302

Cited by 61 publications

(85 citation statements)

References 22 publications

(51 reference statements)

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“…Our findings were later confirmed by other researches [39,40], regarding Dandy-Walker syndrome, vermian hypoplasia, Blake's pouch cyst, and trisomies [13,18] and triploid fetuses that have measurable abnormalities in the posterior brain [40][41][42][43].…”

Section: Limitations Of the First Trimester Scansupporting

confidence: 89%

CNS Abnormalities at 11-14 Weeks

Iliescu¹,

Comanescu²

2017

Neonat Pediatr Med

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Section: Limitations Of the First Trimester Scansupporting

confidence: 89%

CNS Abnormalities at 11-14 Weeks

Iliescu¹,

Comanescu²

2017

Neonat Pediatr Med

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“…The initial observation has drawn attention to the examination of the posterior fossa in the first trimester and since then an increasing number of studies focused on the alterations in the size and appearance of the brain structures in cases with open spina bifida. However, a subsequent prospective study from the same group of investigators as well as other studies proposed that IT is visible and cisterna magna (CM) is partially or completely obliterated [12,13,14,15,16]. The severe reduction or obliteration of the CM causes the alteration of the normal view of the posterior brain consisting of four almost parallel lines (the four-line view) which are from top to bottom: the upper border of the BS, the lower border of the BS, the choroid plexus of the fourth ventricle and the occipital bone (fig.…”

Section: Introductionmentioning

confidence: 99%

Towards Detecting Open Spina Bifida in the First Trimester: The Examination of the Posterior Brain

Kappou

Papastefanou²,

Pilalis³

et al. 2015

Fetal Diagn Ther

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Introduction: Our aim was to examine the value of indirect signs of open spina bifida in the mid-sagittal view of the posterior brain at the 11-13 weeks' ultrasound examination and to summarize the current evidence for the first-trimester diagnosis of spina bifida. Methods: This was a prospective study in routine obstetric population.The presence of four almost parallel lines (four-line view) in the posterior brain was recorded. Biparietal diameter (BPD), intracranial translucency (IT) and cisterna magna (CM) were measured. The ratio of IT to CM (R ratio) was calculated. Results: 2,491 pregnancies were examined prospectively. Updated reference ranges for IT and CM were constructed. There were 3 cases with open spina bifida, and the four-line view was abnormal in 2 of them. The abnormal fetuses had smaller BPD as well as pronounced reduction in the CM and increase in the R ratio. Discussion: Examination of the posterior brain was feasible in all fetuses in the setting of the routine 11-13 weeks' ultrasound examination. Indirect signs of spina bifida are visible in the mid-sagittal view of the posterior brain, and the assessment of these structures can be a reliable tool in the early identification of this abnormality.

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“…If the fetal head remains the answer for the early detection of OSB, should we use axial or parasagittal planes for screening? 60,61,63,65,[68][69][70] The first question, probably the most important one, is extremely difficult to answer, due to the conflict between ethical principles and available human and technical resources, especially in developing countries.…”

Section: Discussionmentioning

confidence: 99%

“…At this GA, as said before, the direct diagnosis on the basis of the myelomeningocele remained extremely challenging, due probably to size restrictions. Posterior brain anomalies, usually having subtle changes, can be yet identified in the parasagittal plane, used for the NT thickness measurement: compression of the fourth ventricle, leading to decrease or disappearance of the normal intracranial translucency (IT), [60][61][62] altered ranges of the brain stem, 63 nonvisualization of the cisterna magna 64,65 (changes that give the subjective impression of the caudal displacement of the brainstem), decreased fronto maxillary facial (FMF) angle.…”

Section: Osb Diagnosis At the End Of The Ft Of Pregnancy -The Limits mentioning

confidence: 99%

First Trimester Anomaly Scan—The Last Redoubt Won: Open Spina Bifida

Novac¹,

Tudorache²,

Gabriel³

et al. 2015

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Open spina bifida (OSB) is a non-lethal fetal anomaly, yet often leads to severe disability. Most cases of open spina bifida are detected at the second trimester fetal anomaly ultrasound scan. The 11 to 13 weeks of amenorrhea scan evolved over the last 20 years from essentially a dating scan, to a genetic scan, and recently to one which includes, in addition to the genetic markers, a basic checklist for examination of the whole fetal anatomy. The direct visualization of the spine at the first trimester (FT) scan remained difficult, despite the wider use of high-reso lution ultrasound machines and the volumetric approach. Thus, indirect intracranial morphological markers for OSB were proposed to diagnose this neural tube defect.The present review aims to describe the specific anatomical feature of the spine and the posterior brain, both on parasagittal and on axial planes, recently proposed for the early detection of OSB.Specialists involved in the prenatal diagnosis will eventually elaborate in the future a screening protocol for OSB in the FT of pregnancy, using the most valuable and easy to obtain marker, in a single 2D plane.The offer of an early diagnosis of possible severe anomalies, such as OSB, is a tool enhancing the autonomy of the pregnant woman.

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Cisterna magna width at 11–13 weeks in the detection of posterior fossa anomalies

Abstract: Objective To construct reference ranges for cisterna magna (CM)

Cited by 61 publications

References 22 publications

CNS Abnormalities at 11-14 Weeks

CNS Abnormalities at 11-14 Weeks

Towards Detecting Open Spina Bifida in the First Trimester: The Examination of the Posterior Brain

First Trimester Anomaly Scan—The Last Redoubt Won: Open Spina Bifida

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