Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells

Sapsrithong, Tarat; Kaewprem, Weeraya; Tongumpai, Sarunya; Nusuetrong, Punnee; Meksuriyen, Duangdeun

doi:10.1016/j.jep.2012.07.027

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…It is a medicinal plant belonged to family Vitaceae [20] and known as asthisamhara in Sanskrit, meaning "which will strengthen the bones." The plant contains significant amounts of Vitamin C, carotene, anabolic steroid substances, and column.…”

Section: Cassia Fistulamentioning

confidence: 99%

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Amrish¹

2018

AJP

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Cancer is a disease in which abnormal cells proliferate in the body. It is a group of various diseases involving uncontrolled multiplication and division of abnormal cells in the body. These abnormal cells form malignant growths which called neoplasm. Nowadays, cancer considered as one of the most prevalent diseases in the world, and its mortality is increasing. It is necessary to investigate new strategies to prevent and treat disease. Herbal medicines block critical biochemical pathways converting normal cells to cancer cells for treatment. Herbal medicines block signal transduction in cancer which is a primary channel, by such as controlling nuclear factor-kB signaling pathway, protein tyrosine kinase pathway, and mitogen-activated protein kinases signal pathways. The various study reported that people with cancer commonly use herbal products because of no side effects on healthy cells. Herbal medicine is one of the most widely used alternative therapies by people with cancer. Clinically proven herbal remedies help to prevent or relieve the symptoms of cancer or treatment side effects by a conventional method. We have discussed various medicinal herbs found in India which have the potential to be used in cancer therapy. This present review will focus on the different medicinal plants containing chemical constituents used in the treatment of cancer with their possible mechanism of action.

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Section: Cassia Fistulamentioning

confidence: 99%

“…The plant contains significant amounts of Vitamin C, carotene, anabolic steroid substances, and column. [20] It is used as an antioxidant in many applications.…”

Section: Cassia Fistulamentioning

confidence: 99%

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Amrish¹

2018

AJP

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“…Cissus quadrangularis has been studied in multiple settings and has been reported to have antioxidant, 16,17 antiobesity, 18 and anti-inflammatory [19][20][21] activity. The variation in functional activity may be explained by the wide array of active chemicals known to be found within the CQ plant (eg, polyphenols).…”

Section: Introductionmentioning

confidence: 99%

Cissus QuadrangularisReduces Joint Pain in Exercise-Trained Men: A Pilot Study

Farney

McCarthy

Lee

2013

The Physician and Sportsmedicine

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“…The plant has been documented in Ayurveda for its medicinal uses in gout syphilis and etc. The stem juice is used to treat scurvy and irregular menstruation, the root is used specifically for bone fracture [21]. A number of studies [22][23][24][25][26] …”

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confidence: 99%

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2018

RJLBPCS

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Present study was aimed to evaluate the preliminary pharmacognosy properties such as antimicrobial, antioxidant and anti-cancer potential of ethanol extract of Cissus quadrangularis. Antimicrobial activity was tested against Staphylococcus aureus, Bacillus subtilis, Vibrio cholera, Vibrio parahaemolyticus, Pseudomonas aeruginosa, Entero toxigenic Excherichia coli (ETEC) andSalmonella typhi by disc diffusion assay. Antioxidant activity was determined by DPPH free radical scavenging assay and ABTS free radical scavenging assay. MCF-7 breast cancer cells were used to investigate the in vitro anti-cancer activity of ethanol extracts of cissus. The anticancer activity MTT assay carried out using MCF7 cell line. The results CQE extract showed more activity against Vibrio parahaemolyticus, Vibrio cholera, ETEC and Salmonella typhi at 5-25 mg/well. The extract also exhibited dose dependent scavenging of DPPH and ABTS radicals. DPPH radicals was more efficient than that of ABTS radicals as revealed by the low IC50 value. MCF-7 breast cancer cells were used to investigate the in vitro anti-cancer activity of ethanol extracts of Cissus. The MTT assay results showed considerable anti-cancer activity in MCF-7 cancer cells, with an IC50 value of 40 µg/ml. Cissus extract effectively inhibited proliferation of MCF-7 cells in a dose-dependent manner over 24h. Thus the compounds of Cissus quadrangularis displayed potential for antioxidant, antibacterial and anti-cancer agents.

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Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells

Cited by 21 publications

References 37 publications

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Cissus QuadrangularisReduces Joint Pain in Exercise-Trained Men: A Pilot Study

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