<i>Cissus Quadrangularis</i>Reduces Joint Pain in Exercise-Trained Men: A Pilot Study

Farney, Tyler M.; McCarthy, Cameron G.; Lee, Sang-Rok

doi:10.3810/psm.2013.09.2021

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Assessment was conducted based on pre-and post-intervention Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. A significant improvement was noted from pre-to post-intervention [25] . In another study which evaluated the healing potential of CQ, 5 out of 9 subjects with maxillofacial fracture were administered with CQ 500 mg thrice a day for 6 weeks.…”

Section: Clinical Evidencementioning

confidence: 81%

Role of Cissus quadrangularis in bone loss pathologies

Nath,

Kar,

Dhadiwal

et al. 2024

Int. J. Orthop. Sci.

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Cissus quadrangularis (CQ) is a well-known medicinal plant from Vitaceae family. It shows various pharmacological activities such as, anti-inflammatory, antioxidant, anti-osteoporotic, antimicrobial, antiobesity, antinociceptive, anticonvulsant, antiglucocorticoid, and antidiabetic activity. Among these, bone healing and anti-osteoporotic properties are the most studied and demonstrated across multiple preclinical and clinical studies. Bone loss is a condition which must be treated with proper medication at its early stages for faster recovery and to maintain quality of life. Bone loss may be due to impaired remodeling or bone fracture or due to pathological conditions like osteoporosis. Current management strategies include most of the synthetic agents that need to be administered for long durations and associated with several adverse effects. Hence there is a need for supportive herbal treatment options which can reduce or prevent bone loss with minimal safety concerns. CQ enhances bone formation and reduces bone resorption process to maintain bone remodeling and bone homeostasis through various mechanisms. With an increasing number of studies and publications on this subject, the exact role played by CQ in the management of bone loss is getting clearer. This narrative review provides a summary of the mechanisms of action of CQ extract as demonstrated across various in-vitro, animal model and clinical studies.

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Section: Clinical Evidencementioning

confidence: 81%

Role of Cissus quadrangularis in bone loss pathologies

Nath,

Kar,

Dhadiwal

et al. 2024

Int. J. Orthop. Sci.

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“…Cissus , native to Africa and Asia, has a long history in traditional medicine for treating conditions such as bone fractures ( Azam et al, 2023 ) and joint pain ( Lakshmanan et al, 2021 ). Scientific research supports its effectiveness in reducing pain and improving joint function in osteoarthritis ( Bloomer et al, 2013 ), as well as in diminishing inflammation and oxidative stress in metabolic syndrome ( Lekshmi et al, 2015 ). Furthermore, Cissus may help prevent weight gain by reducing waist circumference and affecting adiponectin levels ( Chatree et al, 2021 ; Toor et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Cissus quadrangularis L. Powder on Proximate Composition, Physicochemical and Textural Properties of Tteokgalbi

Lee,

Choi

et al. 2024

Food Sci Anim Resour

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We investigated Cissus quadrangularis L. powder (C) use as a natural additive to Tteokgalbi, a traditional Korean meat-based dish. Five distinct Tteokgalbi samples were treated: one without any additives (negative control, NC), one with 1.00% C (C1), 2.00% C (C2), 4.00% C (C3), and 0.10% ascorbic acid (positive control, PC). C addition resulted in changes in composition, quality, and sensory attributes. Moisture content decreased with higher C levels; crude protein varied among the groups, with C1 having the highest crude protein levels and C3 the lowest. Crude fat decreased with increasing C concentration, whereas the carbohydrate content increased. The water-holding capacity notably decreased in the C3 group, resulting in increased cooking loss with higher C concentrations. C treatment altered color and texture, reducing CIE L* and increasing CIE a* before cooking and increasing CIE L* and CIE a* after cooking. CIE b* decreased before cooking but increased thereafter. C-treated Tteokgalbi was less cohesive, chewy, and brittle compared to the NC. The C treatment increased the total phenolic and flavonoid contents and enhanced radical scavenging capacities. It also affects storage characteristics, lowers pH, and increases 2-thiobarbituric acid reactive substances values. The microbial counts were lower in C2 and C3 after 11 days. These findings suggest the potential use of C as a natural meat additive.

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“…People who are carrying out strenuous, high-volume exercises are often associated with joint pain and inflammation. A pilot study was carried out by Bloomer et. al., (2013) in supplementation in healthy, exercise-trained men with joint-specific pain among 29 young men.…”

Section: Hemorrhoidsmentioning

confidence: 99%

A Systemic Review on the Pharmacognosy, Phytochemistry, Pharmacological and Clinical aspects of Edible stemmed vine, Cissus quadrangularis L

2020

AJCRR

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Cissus quadrangularis Linn. belonging to the family Vitaceae is a common perennial climber, which is distributed throughout India. This square stemmed vine is widely used in traditional systems of medicines and parts like stem, roots and shoots are the most important parts, which are used medicinally. The article reveals a wide number of phytochemical constituents that had been isolated from the plant, which plays major role including gallic acid derivatives, steroids, iridoids, flavonoids, stilbenes and triterpenes, which possesses activities like anti inflammatory, anti tumor, gastro protective, antioxidant, antimicrobial and various other important medicinal properties. Many extensive research works had been done to prove its biological activities and pharmacology of its extracts. The current review deals with the enormous amount of updated information of scientific research and reports available in different aspects of this plant involving phytochemical, pharmacology, toxicological and clinical works. This review also includes reports on pharmacognosy, variants and traditional medicinal uses of the plant.

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Cissus QuadrangularisReduces Joint Pain in Exercise-Trained Men: A Pilot Study

Cited by 6 publications

References 33 publications

Role of Cissus quadrangularis in bone loss pathologies

Role of Cissus quadrangularis in bone loss pathologies

Effects of Cissus quadrangularis L. Powder on Proximate Composition, Physicochemical and Textural Properties of Tteokgalbi

A Systemic Review on the Pharmacognosy, Phytochemistry, Pharmacological and Clinical aspects of Edible stemmed vine, Cissus quadrangularis L

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