Cisplatin-induced peptic ulcers, vagotomy, adrenal and calcium modulation

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function

“…These findings are consistent with the reported ability of cisplatin to affect cholinergic function in conscious rats (causing an increase in [ 3 H]-choline uptake into the cardiac region of the stomach), although not with accompanying change in gastric AChE staining, measured three days after treatment in the same study (Aggarwal et al 1994). Differences in species, duration of chemotherapy and or length of time after chemotherapy are likely to contribute to the differences observed.…”

Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use

“…Other mechanisms, however, have been suggested: Cisplatin blocks the release of acetylcholine in the smooth muscles cells, inducing a pyloric spasm and gastric accumulation of hydrochloric acid and enzymes (pepsin and gastrin) that are able to trigger the mucosal damage. Mucosal hypoperfusion and release of mediators of inflammation are further possible mechanisms (Aggarwal, 1994).…”

Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

“…Aside from its useful broad spectrum anti-cancer activity, it has a lot of adverse reactions as well including oxidative stress (Sodhi and Gupta, 1986), lipid peroxidation (Sugihara et al, 1987), hypocalcemia, hypomagnesia (Hodgkinson et al, 2006;Lajer and Daugaard, 1999;Martin et al, 1992), nausea and vomiting (Qiu-hai et al, 2010), ototoxicity (Rybak et al, 2007), stomach distention and nephrotoxicity (Aggarwal et al, 1994). Nausea and vomiting (Glaus et al, 2004;Topal et al, 2005) are the major dose limiting adverse reactions which leads to *Corresponding author.…”