2015
DOI: 10.3892/mmr.2015.3252
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Cisplatin in combination with programmed cell death protein 5 increases antitumor activity in prostate cancer cells by promoting apoptosis

Abstract: Prostate cancer is the most common type of cancer affecting males. The aim of the present study was to investigate the antitumor effect of cisplatin in combination with programmed cell death protein 5 (Pdcd5) on Du145 prostate cancer cells and to elucidate the underlying mechanisms of action. An MTT cell viability assay was performed in order to determine the proliferation rate of Du145 cells. The results demonstrated that Du145 cells treated with cisplatin for 48 h had an IC50 value>200 µM; however, following… Show more

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Cited by 11 publications
(9 citation statements)
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“…However, the majority of chemotherapy drugs pose adverse effects even at therapeutic doses. Consequently, it is imperative to probe alternative effective therapeutic methods that may surmount drug toxicity [58]. 4.7.…”
Section: Methods Of Incorporating Drugs Using Electrospinningmentioning
confidence: 99%
“…However, the majority of chemotherapy drugs pose adverse effects even at therapeutic doses. Consequently, it is imperative to probe alternative effective therapeutic methods that may surmount drug toxicity [58]. 4.7.…”
Section: Methods Of Incorporating Drugs Using Electrospinningmentioning
confidence: 99%
“…Prostate cancer represents the second widespread cancer and about 10% of all cancers in men. 1 Although the incidence of prostate cancer in China, Japan, and other Asian countries is lower than the Western countries, it has grown quite rapidly recent years. 2 Chemotherapy and radiotherapy are the mainstay to treat such a cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Dysregulation of PDCD5 has been found to be involved in different type of tumors (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The antitumor activity of PDCD5 has been also proposed (23)(24)(25)(26)(27)(28)(29) and low expression level of PDCD5 has been suggested to be a prognostic indicator for cancers (30). PDCD5 was also indicated to have the therapeutic potential in the treatment of rheumatoid arthritis and other autoimmune diseases because of its inflammatory effects (31,32).…”
Section: Introductionmentioning
confidence: 99%