Preparation of PCL Electrospun Fibers Loaded with Cisplatin and Their Potential Application for the Treatment of Prostate Cancer

Abstract

Prostate cancer is a global fatal type of cancer. It is a type of cancer that affect men. Signs and symptoms of the disease include blood in the urine, pain when one micturates, and difficulties in penis erection. Cisplatin chemotherapy is a principal treatment normally given to the prostate cancer patients. Nonetheless, on its own, cisplatin loses efficacy once administered due to liver pass effects and other biochemical attacks. In this paper, we looked at preparation of PCL nanoparticles loaded with cisplatin and their potential for the treatment of prostate cancer. PCL nanoparticles protect cisplatin from biochemical attack, thus increasing drug efficacy. Incorporation of P-glycoprotein inhibitors in PCL nanoparticles (NPs) loaded with cisplatin could improve prostate cancer treatment even more.

Electrospun nanofibers for 3-D cancer models, diagnostics, and therapy

“…[57][58][59] These properties have been shown to be intimately related to the diameter, morphology and uniformity of produced nanofibers. 60 Table 1 summarizes the these factors in the electrospinning process and the corresponding affected nanofiber properties. 61 Beyond singleconstituent polymers, polymer blends have been utilized, as well as nanoparticle (NP)-impregnated or drug/ligandimpregnated polymers.…”

Fe3O4 Nanoparticles in Combination with 5-FU Exert Antitumor Effects Superior to Those of the Active Drug in a Colon Cancer Cell Model

“…Over the past decades, remarkable advances have occurred in nanotechnology, particularly nanomedicine, focusing, among others, on novel cancer therapeutics [ 35 ]. NPs can accumulate in cells without being recognized by p -glycoproteins, one of the primary mediators of multidrug resistance, resulting in increased intracellular concentrations of drugs [ 36 ]. Notably, NP carriers exhibit intrinsic abilities affecting cancer and immune cell biological functions [ 37 ].…”

Retracted: Preparation of PCL Electrospun Fibers Loaded with Cisplatin and Their Potential Application for the Treatment of Prostate Cancer

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”