Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin

Li, Mingqiang; Tang, Zhaohui; Lv, Shixian; Song, Wantong; Hong, Hao; Jing, Xiabin; Zhang, Yuanyuan; Chen, Xuesi

doi:10.1016/j.biomaterials.2014.01.018

Cited by 247 publications

(158 citation statements)

References 56 publications

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“…This drug is effective in treating various types of cancer such as breast, lung, prostate, cervical, bone, etc., [1] but doxorubicin has many side effects including hepatotoxic, cardiotoxic, nephrotoxic, and immunosuppression. [2], [3]  Manuscript received November 10, 2016; revised January 24, 2017.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats

Sutejo¹,

Efendi²

2017

IJPMBS

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats

Sutejo¹,

Efendi²

2017

IJPMBS

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“…There were almost no histopathological changes in the organs of both mPEG-b-PGA and control groups, while varying degree of organ micro-morphological changes, especially in heart, liver, and kidney, could be observed in the EPI formulation groups. Acting as anthracycline antitumor drug, the organ damages of EPI in this study were very similar to those of DOX [42]. The main pathological features included: (i) partial myocardial cells disordered and degenerated with inflammatory cell infiltration more or less; (ii) liver tissue appeared congestion with scattered inflammatory cells, and atrophic and eosinophilic hepatocytes could be seen; and (iii) renal interstitial hyperemia occurred, and some renal capsule shrank or even disappeared.…”

mentioning

confidence: 60%

Epirubicin-Complexed Polypeptide Micelle Effectively and Safely Treats Hepatocellular Carcinoma

Ding

et al. 2015

Polymers

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Epirubicin (EPI) once acted as a main agent for HCC chemotherapy. However, the dosage-dependent side effects seriously limit its application in clinic. The purpose of this study is to develop an effective nanocarrier to improve the efficacy and overcome the limitations of EPI. In this regard, the EPI-complexed micelle (i.e., mPEG-b-PGA/EPI) was prepared via the electrostatic interaction between the amino group in EPI and the carboxyl group in PGA segment of methoxy poly(ethylene glycol)-block-poly(L-glutamic acid) (mPEG-b-PGA), and the subsequent hydrophobic interaction among PGA/EPI complexes. The micelle appeared spherical with a diameter at around 90 nm and possessed a pH-sensitive release property of payload. The cytotoxicity and hemolysis assays in vitro, and the maximum tolerated dose tests in vivo confirmed that mPEG-b-PGA was a kind of safe material with excellent biocompatibility, while the drug-loaded micelle could obviously improve the tolerance of EPI. In addition, mPEG-b-PGA/EPI possessed significantly enhanced antitumor efficacy and security toward the H22-xenografted HCC murine model at macroscopic and microscopic levels compared with free EPI. All these results strongly indicate that mPEG-b-PGA/EPI may be a promising nanoplatform for EPI delivery in the chemotherapy of HCC.

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“…Doxorubicin is used for the various types of cancer such as breast, lung, prostate, cervical, bone, etc. (Li, et al, 2014). Doxorubicin is not selective, it is affect not only cancer cells but also normal cells that divide actively.…”

Section: Effect Of Eat Againts Mda Serum Levelsmentioning

confidence: 99%

“…Doxorubicin is antibiotic from tetracyclin class which widely used in treating various types of cancer such as breast, pulmonary, prostate, servics, and bone cancer (Li, et al, 2014), however treatment with doxorubicin for long term reveals several side effects including cardiotoxicity, hepatotoxicity, nephrotoxicity and immunosupression (Burridge, et al, 2016;Chaudhary, et al, 2016;Mohebbati, et al, 2016). Doxorubicin suppress the immune system by decreasing the expression level of IL-2, production of the γ-interferon, natural killer (NK) cells, proliferation of lymphocytes, and rasio CD4+/CD8+ (Zhang, et al, 2005a).…”

Section: Introductionmentioning

confidence: 99%

Immunostimulant Effect of Garlic Chives Leaf Ethanolic Extract (Allium tuberosum) by Increasing Level of Antioxidant at Rats Doxorubicin-Induced Rats

Sutejo

Ariesaka

Prasetyo

et al. 2017

IJCC

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Cancer is one of the leading causes of death in the world, approximately 14 million new cases and 8.2 million deaths each year. Doxorubicin is a well-known chemotherapy drug which frequently used in treating various types of cancer. However, doxorubicin posesses several side effects including cardiotoxic, hepatotoxic, nephrotoxic, and immunosuppression. One of the natural product that can be used as an adjuvant of doxorubicin to reduce the toxic effects is garlic chives (Allium tuberosum). The purpose of this study was to determine the effect of Allium tuberosum based on hematological profile, levels of CD4+, CD8+, and MDA serum of male Wistar rats which induced by doxorubicin. The hematological profile was analyzes by blood smear, levels of CD4+ and CD8+ were conducted by flowcytometry and levels of MDA serum were determined by spectrofotometry. The results showed that the etanolic extract of Allium tuberosum (EAT) increased neutrophil and lymphocyte, percentage of CD4+ cells (p<0.01) and CD8+ cells. It also decreased the levels of serum MDA (p<0.01). These results indicated that EAT work as immunostimulant possibly through an antioxidant mechanism (MDA). It can be concluded that EAT can be developed as adjuvant for doxorubicin.

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Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin

Cited by 247 publications

References 56 publications

Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats

Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats

Epirubicin-Complexed Polypeptide Micelle Effectively and Safely Treats Hepatocellular Carcinoma

Immunostimulant Effect of Garlic Chives Leaf Ethanolic Extract (Allium tuberosum) by Increasing Level of Antioxidant at Rats Doxorubicin-Induced Rats

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