Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration

Li, Keke; Li, Jiwen; Li, Zhongyu; Men, Lei; Zuo, Haibin; Gong, Xiaojie

doi:10.1016/j.phrs.2024.107175

Pharmacological Research

2024

DOI: 10.1016/j.phrs.2024.107175

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Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration

Keke Li,

Jiwen Li,

Zhongyu Li

et al.

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2024

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Cited by 3 publications

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Enhancing chemotherapeutic efficacy: Niosome‐encapsulated Dox‐Cis with MUC‐1 aptamer

Barlas,

Olceroglu,

Ag Seleci

et al. 2024

Cancer Medicine

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BackgroundCancer remains a formidable global health challenge, currently affecting nearly 20 million individuals worldwide. Due to the absence of universally effective treatments, ongoing research explores diverse strategies to combat this disease. Recent efforts have concentrated on developing combined drug regimens and targeted therapeutic approaches.ObjectiveThis study aimed to investigate the anticancer efficacy of a conjugated drug system, consisting of doxorubicin and cisplatin (Dox‐Cis), encapsulated within niosomes and modified with MUC‐1 aptamers to enhance biocompatibility and target specific cancer cells.MethodsThe chemical structure of the Dox‐Cis conjugate was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Liquid Chromatography Quadrupole Time‐of‐Flight Mass Spectrometry (LC‐Q‐TOF/MS). The zeta potential and morphological parameters of the niosomal vesicles were determined through Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM). In vitro assessments of cell viability and apoptosis were conducted on MUC‐1 positive HeLa cells and MUC‐1 negative U87 cells.ResultsThe findings confirmed the successful conjugation of Dox and Cis within the niosomes. The Nio/Dox‐Cis/MUC‐1 formulation demonstrated enhanced efficacy compared to the individual drugs and their unencapsulated combination in both cell lines. Notably, the Nio/Dox‐Cis/MUC‐1 formulation exhibited greater effectiveness on HeLa cells (38.503 ± 1.407) than on U87 cells (46.653 ± 1.297).ConclusionThe study underscores the potential of the Dox‐Cis conjugate as a promising strategy for cancer treatment, particularly through platforms that facilitate targeted drug delivery to cancer cells. This targeted approach could lead to more effective and personalized cancer therapies.

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Enhancing chemotherapeutic efficacy: Niosome‐encapsulated Dox‐Cis with MUC‐1 aptamer

Barlas,

Olceroglu,

Ag Seleci

et al. 2024

Cancer Medicine

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The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

Lin,

Liu,

et al. 2024

Pharmacological Research

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Ginseng Radix et Rhizoma enhanced the effect of metoprolol in chronic heart failure by inhibiting autophagy in male C57BL/6J mice

Zi-chang,

Xiao-ling,

et al. 2024

PLoS ONE

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Background Ginseng Radix et Rhizoma (GS) is frequently used as an adjuvant therapy for patients with heart failure (HF). Metoprolol is widely used in patients with HF. However, there is no report on the combined effects of GS and metoprolol in patients with HF. Objective This study investigated the combined effects of GS and metoprolol in male C57BL/6J mice with HF and the underlying mechanisms. Materials and methods We utilized a mouse myocardial HF model to measure the serum levels of creatine kinase (CK) and creatine kinase-MB form (CK-MB) using an automated biochemical analyzer. Lactate dehydrogenase (LDH) and cardiac troponin (cTnT) levels were determined using enzyme-linked immunosorbent assays. Autophagy of myocardial cells was evaluated using transmission electron microscopy, and changes in signal pathway proteins related to autophagy were analyzed by Western blotting. Results GS combined with metoprolol improved heart function, reduced heart damage, and decreased serum levels of CK, CK-MB, LDH, and cTnT. The combination of GS and metoprolol decreased autophagy in myocardial cells by reducing the levels of autophagy-related proteins (LC3, p62, Beclin1, and Atg5) and increasing the ratios of p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR. Conclusion GS enhanced the anti-heart failure effect of metoprolol. Its mechanism of action might be related to the inhibition of autophagy mediated by the activation of the PI3K/Akt/mTOR pathway.

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Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration

Cited by 3 publications

References 76 publications

Enhancing chemotherapeutic efficacy: Niosome‐encapsulated Dox‐Cis with MUC‐1 aptamer

Enhancing chemotherapeutic efficacy: Niosome‐encapsulated Dox‐Cis with MUC‐1 aptamer

The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

Ginseng Radix et Rhizoma enhanced the effect of metoprolol in chronic heart failure by inhibiting autophagy in male C57BL/6J mice

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