Cisplatin and Etoposide in Childhood Germ Cell Tumor: Brazilian Pediatric Oncology Society Protocol GCT-91

Lopes, Luiz Fernando; Macedo, Cristiane R; Pontes, Elitânia Marinho; Aguiar, Simone dos Santos; Mastellaro, Maria José; Melaragno, Renato; Vianna, Sonia Maria Rossi; Lopes, Paula Azevedo Allemand; Mendonça, Núbia; Almeida, Maria Teresa de Assis; Sonaglio, Viviane; Ribeiro, Karina de Cássia Braga; Santana, Víctor M.; Schneider, Dominik T.; Camargo, Beatriz de

doi:10.1200/jco.2008.16.4202

Cited by 39 publications

(36 citation statements)

References 22 publications

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“…The predominance of advanced disease and non-SE histologies in our series differs from the classical literature, where seminomas and stage I disease is the most common finding [33]. Our hospital is a reference center for TGCT, associated to the Brazilian Childhood Germ Cell Tumor Study Group, a consortium developed to standardize diagnostic assessment and multidisciplinary treatment of TGCT patients in Brazil [34] and for that reason, our series might be biased by more advanced cases. However, the several risk groups were well represented in the study.…”

Section: Discussionmentioning

confidence: 85%

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

et al. 2015

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The abnormal activation of telomerase, codified by the telomerase reverse transcriptase (TERT) gene, is related to one of cancer hallmarks. Hotspot somatic mutations in the promoter region of TERT, specifically the c.-124:C>T and c.-146:C>T, were recently identified in a range of human cancers and have been associated with a more aggressive behavior. Testicular germ cell tumors frequently exhibit a good prognosis; however, the development of refractory disease is still a clinical challenge. In this study, we aim to evaluate for the first time the presence of the hotspot telomerase reverse transcriptase gene promoter mutations in testicular germ cell tumors. A series of 150 testicular germ cell tumor cases and four germ cell tumor cell lines were evaluated by PCR followed by direct Sanger sequencing and correlated with patient's clinical pathological features. Additionally, we genotyped the telomerase reverse transcriptase gene promoter single nucleotide polymorphism rs2853669 (T>C) located at −245 position. We observed the presence of the TERT promoter mutation in four patients, one exhibited the c.-124:C>T and three the c.-146:C>T. No association between TERT mutation status and clinicopathological features could be identified. The analysis of the rs2853669 showed that variant C was present in 22.8 % of the cases. In conclusion, we showed for the first time that TERT promoter mutations occur in a small subset (~3 %) of testicular germ cell tumors.

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Section: Discussionmentioning

confidence: 85%

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

et al. 2015

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“…A recent study from the Osteosarcoma Brazilian Group indicated an overall survival of 60% for patients with nonmetastatic disease; a large tumor size was observed in 43% of the cases and was not associated with longer lag time (23). After the introduction of a standard protocol, the five-year overall survival for high-risk patients with germ-cell tumors was 83.3%, which is particularly relevant to the treatment protocols in small institutions with limited experience in the treatment of this rare disease (24). …”

Section: Discussionmentioning

confidence: 99%

Childhood cancer mortality trends in Brazil, 1979 – 2008

Ferman¹,

Santos²,

Ferreira³

et al. 2013

Clinics

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OBJECTIVES:Childhood cancer mortality has substantially declined worldwide as a result of significant advances in global cancer care. Because limited information is available in Brazil, we analyzed trends in childhood cancer mortality in five Brazilian regions over 29 years.METHODS:Data from children 0-14 years old were extracted from the Health Mortality Information System for 1979 through 2008. Age-adjusted mortality rates, crude mortality rates, and age-specific mortality rates by geographic region of Brazil and for the entire country were analyzed for all cancers and leukemia. Mortality trends were evaluated for all childhood cancers and leukemia using joinpoint regression.RESULTS:Mortality declined significantly for the entire period (1979-2008) for children with leukemia. Childhood cancer mortality rates declined in the South and Southeast, remained stable in the Middle West, and increased in the North and Northeast. Although the mortality rates did not unilaterally decrease in all regions, the age-adjusted mortality rates were relatively similar among the five Brazilian regions from 2006-2008.CONCLUSIONS:Childhood cancer mortality declined 1.2 to 1.6% per year in the South and Southeast regions.

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“…With regard to the therapeutic strategies, previous experts summarized their experiences including surgery, chemotherapy, radiotherapy, and high-dose chemotherapy with stem cell support, using small samples (Rodney et al 2010; Kang et al 2008; Bokemeyer et al 2001; Lopes et al 2009; Sakurai et al 2004; Bokemeyer et al 2003; Mann et al 2000). In this study, patients were categorized into four groups: those who received three treatments surgery, chemotherapy, and radiotherapy irrespective of the sequence, those who received two treatments chemotherapy plus surgery or radiotherapy, and those who received single treatment chemotherapy or surgery.…”

Section: Discussionmentioning

confidence: 99%

Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum

Liu

Zhang

Liang

et al. 2011

J Cancer Res Clin Oncol

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ObjectiveThe aim of this study was to evaluate the clinical characteristics and survival outcomes of patients with primary mediastinal germ cell tumor (PMGCT) by identifying the prognostic factors and efficacies of different treatment modalities.MethodsFifty-five patients with PMGCT who were treated consecutively at Cancer Center, Sun Yat-sen University, Guangzhou, from 1988 to 2010 were evaluated retrospectively.ResultsFifty-two men and 3 women with a median age of 25 years were identified, of whom 17 (30.9%) had pure seminomatous, 38 (69.1%) had nonseminomatous histology, 27 (49.1%) had tumor located at mediastinum, 20 (36.4%) had lung metastases and/or effusions, and 8 (14.5%) had distant metastases. Three treatments surgery, chemotherapy, and radiotherapy were performed in 11 (20%) patients, two treatments chemotherapy plus surgery or radiotherapy were performed in 25 (45.6%), and single treatment surgery or chemotherapy was performed in 17 (30.9%). The other two patients (3.6%) received no treatment. After a median follow-up time of 31.4 months, the 5-year survival rate was 52%. The median overall survival time was 87.9 months. Patients who received two treatments had the longest survival time of 118.3 months, P = 0.000. Those who had pure seminoma histology, whose tumor confined to the mediastinum and who achieved complete or partial remission at initial evaluation, who had complete resection and radiotherapy were considered to have better prognosis according to univariate analysis. On multivariate analysis, extension and response rate at initial evaluation were independently predictive of survival.ConclusionsPrimary mediastinal germ cell tumor is rare with a dominant frequency in young male patients. Chemotherapy combined with local therapy like surgery or radiotherapy is a reasonable treatment strategy recommended. Extension and initial remission rate are independent prognostic factors.

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Cisplatin and Etoposide in Childhood Germ Cell Tumor: Brazilian Pediatric Oncology Society Protocol GCT-91

Cited by 39 publications

References 22 publications

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

Childhood cancer mortality trends in Brazil, 1979 – 2008

Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum

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