Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells

Wang, Yunfei; Zhou, Jinhua; Qiu, Lihua; Wang, Xinran; Chen, Lilan; Liu, Ting; Di, Wen

doi:10.1016/j.biomaterials.2014.01.035

Cited by 109 publications

(50 citation statements)

References 24 publications

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“…It interacts with guanine and adenine N7 atoms located in the DNA major groove, leading to DNA bending and interfering with its replication, transcription as well as other nuclear functions, thus, arresting cancer cell proliferation and tumor growth (Cepeda et al, 2007). Despite its clinical success, intravenous Cis administration can lead to nephrotoxicity, bone marrow toxicity, intractable vomiting, peripheral neuropathy, deafness, seizures and blindness (Genc et al, 2014;Wang et al, 2014). Drug resistance during therapy is another important limitation to its use requiring the use of increasing doses (Dzamitika et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Abdel-Bar

Abdel-Reheem

Osman

et al. 2014

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Abdel-Bar

Abdel-Reheem

Osman

et al. 2014

International Journal of Pharmaceutics

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“…Cisplatin (CDDP)-sodium alginate (SA)-liposome may be a promising formulation for delivery of CDDP in treatment of ovarian carcinoma with enhanced efficiency and fewer adverse effects. Since epidermal growth factor receptor (EGFR) is overexpressed in many ovarian cancers, EGF was used for active targeting [42]. Moreover, biomolecules such as DNA and proteins can be entrapped in alginate matrices by relatively mild gelation processes and free of organic solvents.…”

Section: Application Of Alginate In Drug Deliverymentioning

confidence: 99%

Bacterial-derived biopolymers: Advanced natural nanomaterials for drug delivery and tissue engineering

Mokhtarzadeh

Alibakhshi

Hejazi

et al. 2016

TrAC Trends in Analytical Chemistry

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“…Lin et al also showed that cisplatin‐incorporated gelatin nanoparticles (GP) with biotinylated‐EGF (bEGF) modification (GP‐Pt‐bEGF) resulted in much higher Pt concentrations in A549 cells (high EGFR expression) than in HFL1 cells (low EGFR expression) . EGF modified liposomes carrying cisplatin (CS‐EGF‐Lip) showed enhanced drug delivery to EGFR‐positive ovarian tumor tissues and improved antitumor efficacy with much lower system toxicity in mice . Cetuximab (CTX), a monoclonal antibody (mAb), was used to treat certain (wild‐type KRAS) metastatic colorectal cancer (CRC) expressing EGFR.…”

Section: Targeted Deliverymentioning

confidence: 99%

Multifunctional platinum‐based nanoparticles for biomedical applications

Cheng

Liu

2016

WIREs Nanomed Nanobiotechnol

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Platinum-based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier-based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor-specific localization as well as tumor cell uptake. The introduction of stimuli-responsive groups into drug delivery systems can further achieve spatially and temporally controlled drug release in response to specific stimuli. Combination therapy strategies have been used to promote synergetic efficacy and overcome the resistance of platinum drugs. The tumor-localized drug delivery strategies exhibit benefits for preventing local tumor recurrence. In addition, the combination of platinum drugs and imaging agents in one unity allows the cancer diagnostics for real-time monitoring the distribution of drug-loaded nanoparticles inside the body and tumor. This review discusses recent scientific advances in multifunctional nanoparticle formulations of platinum drugs, and these designs exhibit new potential of multifunctional nanoparticles for delivering platinum-based anticancer drugs. WIREs Nanomed Nanobiotechnol 2017, 9:e1410. doi: 10.1002/wnan.1410 For further resources related to this article, please visit the WIREs website.

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Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells

Cited by 109 publications

References 24 publications

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Bacterial-derived biopolymers: Advanced natural nanomaterials for drug delivery and tissue engineering

Multifunctional platinum‐based nanoparticles for biomedical applications

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