Cisatracurium stimulates testosterone synthesis in rat and mouse Leydig cells via nicotinic acetylcholine receptor

Abstract

In addition to the hypothalamic-pituitary-gonadal axis, the nervous system may play a key role in Leydig cell function. Previous studies have shown that some nerve fibres reach the rat and human testes and may have an effect on Leydig cells. 1,2 The destruction of testicular innervation led to Leydig cell apoptosis and impaired Leydig cell function. 1 The nicotinic acetylcholine receptor (nAChR) is a transmembrane ion channel that contains five subunits α2βγδ and belongs to the ligand-gated receptor family. 3 It is primarily distributed

The Therapeutic Effects of Epigallocatechin-3-gallate and Rutin, either Alone or in Combination with Low-dose radiation, against Testicular Injury Evoked by Nicotine in Rats

“…Moreover, testosterone levels were reduced following nicotine administration, consistent with prior findings (Jana et al, 2010;Kolawole et al, 2019;Ashoub et al, 2021). Many factors contributed to the decline in testosterone levels, including a decrease in the FSH and LH levels, which maintains the testosterone levels via the hypothalamic-pituitary-testicular axis (Tweed et al, 2012;Oyeyipo et al, 2013), disruption of testicular cytoarchitecture, which negatively affects the number and function of Leydig cells (Oyeyipo et al, 2010) and cholinergic nicotine agonist activity, that inhibits testosterone secretion (Ni et al, 2020).…”

The evaluation of sea cucumber (Acaudina leucoprocta) peptide on sex hormone regulation in normal and premature ovarian failure female mice

“…44 Cisatracurium significantly increased the cAMP level to enhance T synthesis, while nicotine and lobeline downregulated it. 45 In this study, SCP intervention significantly increased cAMP expression, which resulted in the upregulation of the sterol transport-related gene StAR in the ovaries of POF mice. The increases in cAMP lead to elevated PKA activity, which in turn can increase StAR expression.…”

Natural Astaxanthin Improves Testosterone Synthesis and Sperm Mitochondrial Function in Aging Roosters

“…StAR regulates the acute transport of cholesterol from the outer to the inner membrane of mitochondria in the testes. As P450scc catalyzes the conversion of cholesterol into 22R-hydroxycholesterol in the inner mitochondrial membrane, the double bond of 22R-hydroxycholesterol is cleaved to produce pregnenolone [ 27 ]. Finally, 3β-HSD catalyzes pregnenolone to testosterone in the endoplasmic reticulum [ 28 ].…”