Cisapride treatment for gastro-oesophageal reflux in children

Augood, C; MacLennan, Suzanna C; Gilbert, Ruth; Logan, Stuart

doi:10.1002/14651858.cd002300

Cited by 40 publications

(47 citation statements)

References 31 publications

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“…A cisaprida apresenta efeitos pró-cinéticos no esfíncter esofágico inferior e no estôma-go 54 . Dentre as drogas usadas no tratamento da DRGE na criança, certamente a cisaprida é a que mais foi avaliada em estudos controlados e randomizados.…”

Section: Tosse Crônica Inespecíficaunclassified

“…Lactente não ganha peso e apresenta vômitos freqüentes Mudanças no estilo de vida e pró-cinéticos associado a IH2 Tabela 1 -Resumo do tratamento das síndromes esofágicas e extra-esofágicas da DRGE da em alguns estudos com a droga 2,55-57 , embora uma revisão realizada pela Cochrane Collaboration tenha indicado apenas a existência de melhora do índice de refluxo 54 . A cisaprida nunca foi liberada para menores de 12 anos, mas foi amplamente prescrita para crianças nessa faixa etária em todo o mundo 58 .…”

Section: Situação Clínica Tratamentounclassified

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Treatment of gastroesophageal reflux disease

Guimarães¹,

Marguet²,

Camargos³

2006

J Pediatr (Rio J)

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Objective: To review the literature on the treatment of gastroesophageal reflux disease (GERD) with emphasis on pharmacological aspects. To identify particularities of pharmacological treatment of esophageal and extraesophageal manifestations of the disease.Sources: Electronic search of the PubMed/MEDLINE and Cochrane Collaboration databases. Controlled and randomized studies published since 2000 and reviews representing consensus positions and directives published within the last 10 years were identified. Summary of the findings:The drugs currently available for the treatment of GERD do not act in the primary mechanism of the disease, i.e., transitory relaxation of the lower esophageal sphincter. Pharmacological treatment of GERD with symptoms or with esophageal injury is based on the suppression of acid secretion, particularly with proton pump inhibitors. When the hyperreactivity of the lower airways coexists with esophageal GERD symptoms, suppression of acid secretions should be of benefit in managing the respiratory disease in the presence of a causal relationship; however, this is not usual. When esophageal symptoms are not present, esophageal 24-hour pH study should be carried out prior to starting pharmacological treatment for GERD. Improvement of respiratory symptoms may be delayed with relation to esophageal symptoms. It is common for GERD to recur and pharmacological treatment should be repeated or continued indefinitely, depending on clinical presentation of the disease. Conclusions:The strategies that have been proposed for the pharmacological treatment of GERD in children are primarily based on studies of case series or on studies with adults. There have been very few controlled and randomized studies in children. Undertaking a greater number of these studies might reinforce existing aspects or establish new aspects of management.J Pediatr (Rio J). 2006;82(5 Suppl):S133-45: Gastroesophageal reflux, child, drug therapy, esophagitis, respiratory tract diseases, asthma. ResumoObjetivo: Rever a literatura sobre tratamento da doença do refluxo gastroesofágico (DRGE) com ênfase nos aspectos farmacológi-cos. Identificar particularidades do tratamento farmacológico nas manifestações esofágicas e extra-esofágicas da doença.Fontes de dados: Busca eletrônica na base de dados PubMed/ MEDLINE e Cochrane Collaboration. Procurou-se identificar estudos controlados e randomizados publicados a partir de 2000, bem como revisões que representassem consensos e diretrizes publicados nos últimos 10 anos.Síntese dos dados: Nenhuma das drogas atualmente usadas no tratamento da DRGE altera comprovadamente o mecanismo principal da doença, ou seja, os relaxamentos transitórios do esfíncter esofágico inferior. O tratamento farmacológico da DRGE com sintomas ou com lesões esofágicas é baseado na inibição da secreção ácida, em particular pelos inibidores da bomba de prótons (IBP). Nas situações em que a hiper-reatividade das vias aéreas inferiores coexiste com sintomas esofágicos da DRGE, a inibição da secreção ácida deve...

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Section: Tosse Crônica Inespecíficaunclassified

Section: Situação Clínica Tratamentounclassified

Treatment of gastroesophageal reflux disease

Guimarães¹,

Marguet²,

Camargos³

2006

J Pediatr (Rio J)

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“…Thus ADRs from specific ingredients/excipients may be expressed differently in adults and children. A good example for this kind of poisoning is the life-threatening gasping syndrome seen in infants exposed to benzyl alcohol (26). • In the case of life-long treatment for chronic diseases, the total duration of treatment is longer if started in childhood.…”

Section: Post-marketing Monitoring Of Medicine Safety For Medicines Amentioning

confidence: 99%

Untitled

2016

IJPSR

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“…Cisapride has proven prokinetic effects on the lower esophageal sphincter and the stomach. 54 Of all the drugs used in GERD treatment with children, it is without doubt cisapride that has been most thoroughly evaluated in controlled and randomized studies.…”

Section: Prokineticsmentioning

confidence: 99%

“…54 Cisapride was never licensed for patients under 12 years old, but was widely used on children in that age group worldwide. 58 Nevertheless, cardiac effects, potentially related to its administration, induced increases in QT interval, arrhythmia and sudden death led to restrictions on the use of cisapride and it was later withdrawn.…”

Section: Prokineticsmentioning

confidence: 99%

Tratamento da doença do refluxo gastroesofágico

Guimarães

Marguet

Camargos

2006

J. Pediatr. (Rio J.)

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Objective: To review the literature on the treatment of gastroesophageal reflux disease (GERD) with emphasis on pharmacological aspects. To identify particularities of pharmacological treatment of esophageal and extraesophageal manifestations of the disease.Sources: Electronic search of the PubMed/MEDLINE and Cochrane Collaboration databases. Controlled and randomized studies published since 2000 and reviews representing consensus positions and directives published within the last 10 years were identified. Summary of the findings:The drugs currently available for the treatment of GERD do not act in the primary mechanism of the disease, i.e., transitory relaxation of the lower esophageal sphincter. Pharmacological treatment of GERD with symptoms or with esophageal injury is based on the suppression of acid secretion, particularly with proton pump inhibitors. When the hyperreactivity of the lower airways coexists with esophageal GERD symptoms, suppression of acid secretions should be of benefit in managing the respiratory disease in the presence of a causal relationship; however, this is not usual. When esophageal symptoms are not present, esophageal 24-hour pH study should be carried out prior to starting pharmacological treatment for GERD. Improvement of respiratory symptoms may be delayed with relation to esophageal symptoms. It is common for GERD to recur and pharmacological treatment should be repeated or continued indefinitely, depending on clinical presentation of the disease. Conclusions:The strategies that have been proposed for the pharmacological treatment of GERD in children are primarily based on studies of case series or on studies with adults. There have been very few controlled and randomized studies in children. Undertaking a greater number of these studies might reinforce existing aspects or establish new aspects of management.J Pediatr (Rio J). 2006;82(5 Suppl):S133-45: Gastroesophageal reflux, child, drug therapy, esophagitis, respiratory tract diseases, asthma. The symptoms of GERD are less common than the symptoms of GER, but, even so, are very prevalent. A prevalence study reported weekly heartburn sensation and acid regurgitation in approximately 2% of children aged 3 to 9 years and in 5% to 8% of 10 to 17 year-olds. REVIEW ARTICLEHeartburn alone was identified in 17.8% of the children in the older age group. 7 In the Western world, the prevalence of GERD among adults has been estimated from 10% to 20%. 5The refluxate may be exclusively acidic or mixed with duodenum-gastric reflux. Acid reflux is easier to identify and consequently the pathophysiology, diagnosis and treatment are better known. The bile reflux is little understood, but it has been related to severe esophagitis. 8 The case of mixed reflux diagnosis is highly problematic, and is one of the limitations of pH studies. There are no specific clinical trials on mixed reflux in the literature. has not specified the classification by age group, and most of the definitions proposed are applicable to adult patients. Notwithstan...

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Cisapride treatment for gastro-oesophageal reflux in children

Cited by 40 publications

References 31 publications

Treatment of gastroesophageal reflux disease

Treatment of gastroesophageal reflux disease

Untitled

Tratamento da doença do refluxo gastroesofágico

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