Cisapride does not improve precolonoscopy bowel preparation with either sodium phosphate or polyethylene glycol electrolyte lavage

Martínek, Jan; Hess, J; Delarive, Joakim; Jornod, Phillipe; Blum, A. L.; Pantoflickova, D.; Fischer, Michael J.M.; Dorta, Gian

doi:10.1067/mge.2001.116562

Cited by 61 publications

(49 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cisapride stimulates acetylcholine release from the postganglionic myenteric plexus as well as gastrointestinal peristaltic activity. Cisapride has been used as a prokinetic agent along with lavage solution for bowel preparation and has been demonstrated to shorten the required time period for precolonoscopic bowel preparation and to decrease the lavage solution volume [8, 9], although these results have been difficult to reproduce [11, 22]. However, use of cisapride in this setting is associated with serious unexpected side effects, so it has been withdrawn from the market [23, 24].…”

Section: Discussionmentioning

confidence: 99%

“…Coadministration of cisapride or laxatives such as sennnoside and bisacodyl with oral lavage solution has been reported to be useful for effective bowel preparation [8,9,10,11,12]. Cisapride stimulates acetylcholine release from the postganglionic myenteric plexus as well as gastrointestinal peristaltic activity.…”

Section: Discussionmentioning

confidence: 99%

“…Cisapride has been evaluated as a potential prokinetic candidate for bowel preparation [8,9,10,11,12]; however, it is no longer used in this setting due to its serious side effects. The value of other prokinetics, including mosapride citrate and itopride hydrochloride, has not yet been fully investigated [13, 14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Mishima

Amano²,

Okita³

et al. 2008

Digestion

View full text Add to dashboard Cite

Background and Aim: Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy. Methods: 613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation. Results: Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone. Conclusion: Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Mishima

Amano²,

Okita³

et al. 2008

Digestion

View full text Add to dashboard Cite

show abstract

“…On the other hand, inadequate bowel cleansing of patients is not infrequent under PEGbased regimes, probably because of its huge volume and unpleasant taste (2)(3)(4)(5). For this reason, reducing the amount of PEG-EL, splitting the whole dose, and adding medications (such as prokinetics or laxatives) have been investigated by researchers in recent years (6)(7)(8)(9)(10)(11)(12)(13). Besides NaP solutions and PEG-EL regimes, sennoside calcium a + b solutions (X-M solution, Yenişehir Laboratuarı, Ankara, Turkey) have also been used in Turkey.…”

Section: Introductionmentioning

confidence: 99%

What is the main target: a clearer colon with a sennoside-based regime, or adequate bowel cleansing before colonoscopy with a PEG-EL-based regime?

Altınbaş¹,

Yılmaz²,

Aktaş³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: Even though polyethylene glycol-electrolyte lavage (PEG-EL)-based regimes have become the gold standard in recent years, to finish drinking 4 L of PEG-EL solution can be difficult. The quality of sennoside-based bowel-cleansing regimes used in Turkey has been known for some time. Therefore, we aimed to investigate the efficacy of both bowel-cleansing regimes. Materials and methods:Patients over 18 years old undergoing elective colonoscopic procedures between January and March 2011 were included in the study. The patients were divided into 2 groups; in Group 1, 91 patients were given sennoside a + b calcium 500 mg/250 mL (X-M solution, Yenişehir Laboratuarı, Ankara, Turkey), and in Group 2, 94 patients were given 4 L of PEG-EL (Golytely, Boston, MA, USA). Results:The mean age of the patients and the male distribution were similar in the 2 groups. Both inadequate bowel cleansing and the best cleansed bowels were seen in Group 1. The number of inadequate colonoscopies declined when using a whole bowel-cleansing regime from 24.5% to 19.3% in Group 2, but it did not decline in Group 1. Conclusion:The best bowel cleansing can be achieved with sennoside-based regimes, whereas a greater proportion of adequate results via colonoscopy were reached with the PEG-EL-based regimes.

show abstract

“…Unfortunately, there is currently no preparation which meets all of these criteria [1]. Thus, numerous clinical trials have assessed prokinetic and spasmolytic agents, ascorbic acid, olive oil, orange juice, and pineapple juice in an effort to improve the effectiveness and tolerance of colonoscopic preparation regimens [8][9][10][11][12][13]. From these preparations, the use of prokinetic and spasmolytic agents has not had any additive effects.…”

Section: Introductionmentioning

confidence: 99%

Adding stewed apricot juice to sena improves the right-side and overall colon cleansing quality for colonoscopy preparation

Yaşar

Abut

Kayadibi

et al. 2017

FFHD

View full text Add to dashboard Cite

Citation: Yasar B., Abut E, Kayadibi H., Akdogan F., Gonen C. Adding stewed apricot juice to senna improves quality of colon cleansing in preparation for colonoscopy. Functional Foods in Health and Disease 2017; 7(1):54-67 ABSTRACT Background: To achieve optimal colonoscopic examination, the bowel must be sufficiently cleansed. However, none of the currently available colonoscopy preparation regimens is safe, efficient, and comfortable. The aim of this study was to determine whether adding stewed apricot juice to senna increased patient comfort and improved bowel cleansing during colonoscopy preparation.Methods: Outpatients of both genders who were over 18 years old and were referred for elective colonoscopy were randomly allocated to drink stewed apricot juice with senna or senna by itself. The quality of the colon cleansing was evaluated using the Ottawa scale. Patient tolerance and adverse events were evaluated through the completion of a questionnaire. Results:The study included a total of 128 patients in the randomization procedure. A significantly greater cleansing effect was observed using stewed apricot juice plus senna in the right and transverse colon (p = 0.038, p = 0.037 respectively). It was also determined that in the stewed apricot juice plus senna group, overall cleansing was superior (p < 0.001), total colonoscopy (17.6 min vs. 22.8 min, p = 0.048) and cecal intubation (7.4 min vs. 11.2 min, p = 0.042) times were shorter, and the colonoscopy procedure was easier (79.4% vs. 49.2%, p < 0.001). No differences were observed between the groups with respect to patient acceptance, compliance, and adverse

show abstract

Cisapride does not improve precolonoscopy bowel preparation with either sodium phosphate or polyethylene glycol electrolyte lavage

Cited by 61 publications

References 15 publications

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

What is the main target: a clearer colon with a sennoside-based regime, or adequate bowel cleansing before colonoscopy with a PEG-EL-based regime?

Adding stewed apricot juice to sena improves the right-side and overall colon cleansing quality for colonoscopy preparation

Contact Info

Product

Resources

About