Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Debruille, J. Bruno; Kumar, Namita; Saheb, Dominique; Chintoh, Araba; Gharghi, Daryoush; Lionnet, Claire; King, Suzanne

doi:10.1016/j.ijpsycho.2009.10.004

Cited by 7 publications

(7 citation statements)

References 77 publications

(90 reference statements)

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“…The effect of each schizotypal factor was thus studied while controlling for the effects of the two remaining factors. The N400 protocol used was designed to circumvent the effect of the deficit of the processing of prior context (Debruille et al, 2010). The source of the variations of N400 effects was assessed by measuring correlations in both the exemplar and the non‐exemplar categories.…”

Section: Discussionmentioning

confidence: 99%

“…M. Pre´vost et al the processing of prior context (Debruille et al, 2010). The source of the variations of N400 effects was assessed by measuring correlations in both the exemplar and the non-exemplar categories.…”

Section: Discussionmentioning

confidence: 99%

“…This was aimed at facilitating the processing of the context so that it produced the same effects on the processing of the target word (i.e., on the second word of the trial) in patients as in normals. A previous study using this particular protocol reported an absence of significant differences between patients and normal controls in the ERPs evoked by such invariant context words (Debruille, Kumar, Saheb, Chintoh, Gharghi, et al, 2010). Thus, if the disorganization trait is found to have an effect on the N400s to the targets of our study, it will be more likely to be due to a deficit in processing the targets themselves, which would, nevertheless, have to be confirmed by an absence of effects of schizotypal traits on each of the components of the ERPs elicited by the context word.…”

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confidence: 85%

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Schizotypal traits and N400 in healthy subjects

et al. 2010

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We examined whether correlations previously found between symptoms of schizophrenia patients and the amplitude of an event-related potential (ERP), the N400, could be also found between schizotypal experiences of healthy subjects and the N400. We chose a semantic categorization task previously used with patients. Schizotypal experiences were measured with the schizotypal personality questionnaire (SPQ). The effects of the other factors were controlled for when assessing the correlations between each SPQ factor and N400s. These correlations were assessed at each electrode site to see whether their distribution on the scalp follows that of the N400 effect. Disorganization and interpersonal scores were found to correlate with ERPs in the N400 time window, as previously reported for the comparable symptoms of patients. However, the scalp distribution of these correlations differed from that of the N400 effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Schizotypal traits and N400 in healthy subjects

et al. 2010

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“…To address some of the discrepancies across the studies mentioned above, a particular semantic categorization task 65 was chosen to measure practice effects on RTs and N400 amplitudes for the present study. In this task, the question-word "ANIMAL?"…”

Section: Introductionmentioning

confidence: 99%

Quantifying the effects of practicing a semantic task according to subclinical schizotypy

Diao,

Demchenko,

Asare

et al. 2024

Sci Rep

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The learning ability of individuals within the schizophrenia spectrum is crucial for their psychosocial rehabilitation. When selecting a treatment, it is thus essential to consider the impact of medications on practice effects, an important type of learning ability. To achieve this end goal, a pre-treatment test has to be developed and tested in healthy participants first. This is the aim of the current work, which takes advantage of the schizotypal traits present in these participants to preliminary assess the test’s validity for use among patients. In this study, 47 healthy participants completed the Schizotypal Personality Questionnaire (SPQ) and performed a semantic categorization task twice, with a 1.5-hour gap between sessions. Practice was found to reduce reaction times (RTs) in both low- and high-SPQ scorers. Additionally, practice decreased the amplitudes of the N400 event-related brain potentials elicited by semantically matching words in low SPQ scorers only, which shows the sensitivity of the task to schizotypy. Across the two sessions, both RTs and N400 amplitudes had good test–retest reliability. This task could thus be a valuable tool. Ongoing studies are currently evaluating the impact of fully deceptive placebos and of real antipsychotic medications on these practice effects. This round of research should subsequently assist psychiatrists in making informed decisions about selecting the most suitable medication for the psychosocial rehabilitation of a patient.

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“…Most of the studies relating to the definition of psy chophysiological differences in reactions to verbal emotional stimulus in normal and in schizophrenia, is dedicated to the late components evoked potential [8], and to a much lesser degree, there are studies that examine the early stages of perception and processing of emotionally shaped information, particularly in patients with schizophrenia in the acute psychotic period without receiving neuroleptic treatment [9].…”

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confidence: 99%

Neurophysiological features of perception to emotional stimuli in norm and patients with paranoid

Arkhipov

Стрелец

2015

Hum Physiol

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The latencies and amplitudes of the P100 and N170 components of event related potentials (ERPs) upon presentation of neutral and threatening visual stimuli have been studied in healthy persons and patients with schizophrenia. The studied patients had acute psychosis with a predominance of hallucinatory paranoid syndrome and did not receive antipsychotic therapy, i.e. when the disturbances of sensory percep tion were mostly pronounced. Analysis of early component P100 and intermediate one N170 of event relative potentials (ERPs) in the control group healthy showed the increase of excitation to emotionally threatening stimuli; at all sites the amplitude increased and the latency shortened. In the group of patients with schizo phrenia, the analysis of components P100 and N170, in contrast, showed the increased latency and decreased ampli tude. The obtained data point to pathological inhibition underlying the ERPs to emotionally significant stimuli.

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Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study

Cited by 7 publications

References 77 publications

Schizotypal traits and N400 in healthy subjects

Schizotypal traits and N400 in healthy subjects

Quantifying the effects of practicing a semantic task according to subclinical schizotypy

Neurophysiological features of perception to emotional stimuli in norm and patients with paranoid

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