Circumventing the blood–brain barrier

Shen, Helen

doi:10.1073/pnas.1716187114

Cited by 8 publications

(6 citation statements)

References 9 publications

(9 reference statements)

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“…The BBB enabled just a few molecules to get through, limiting Rg1 ability to boost neuroprotection function in the cerebral ischemia region. 55 , 58 The high expression of transferrin receptor (TfR) in cerebral cortex microvessels may help the nanoparticles traverse the BBB by endocytosis. 59 , 60 c-Poly glutamic acid (PGA), the optimal drug carrier, was created by biological fermentation and was safe, nontoxic, degradable, and immunogenic.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Wang,

Li,

Wang

et al. 2024

IJN

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Angiogenesis, or the formation of new blood vessels, is a natural defensive mechanism that aids in the restoration of oxygen and nutrition delivery to injured brain tissue after an ischemic stroke. Angiogenesis, by increasing vessel development, may maintain brain perfusion, enabling neuronal survival, brain plasticity, and neurologic recovery. Induction of angiogenesis and the formation of new vessels aid in neurorepair processes such as neurogenesis and synaptogenesis. Advanced nano drug delivery systems hold promise for treatment stroke by facilitating efficient transportation across the the blood-brain barrier and maintaining optimal drug concentrations. Nanoparticle has recently been shown to greatly boost angiogenesis and decrease vascular permeability, as well as improve neuroplasticity and neurological recovery after ischemic stroke. We describe current breakthroughs in the development of nanoparticle-based treatments for better angiogenesis therapy for ischemic stroke employing polymeric nanoparticles, liposomes, inorganic nanoparticles, and biomimetic nanoparticles in this study. We outline new nanoparticles in detail, review the hurdles and strategies for conveying nanoparticle to lesions, and demonstrate the most recent advances in nanoparticle in angiogenesis for stroke treatment.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Wang,

Li,

Wang

et al. 2024

IJN

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“…In some drugs currently on the market, antidepressants and medications for schizophrenia and epilepsy, along with caffeine and nicotine also can readily dissolve into the lipid membranes that encase blood–brain barrier cells. Thereby, most of the small molecule combinations also have been explored to across the BBB [ 114 ]. The current FDA-approved pharmacological treatments for CNS tumors such as doxorubicin, carmustine, trastuzumab, and temozolomide have been successfully introduced across the BBB [ 115 ].…”

Section: Future Challenges Of Delivery Drug Across Bbb To Brainmentioning

confidence: 99%

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

Liu

Liang

et al. 2018

Cells

229

129

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The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.

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“…The very first researcher that introduced the concept of BBB was Lena Stern [9], a pioneer in the neuroscience field that coined the term hematoencephalic barrier to describe the BBB. Other scientists worthy of mention for their contribution to the discovery of the BBB’s functional and anatomical organization are Ehrlich, Lewandowsky, and Goldmann [10]. According to Sweeney et al [11], the BBB is defined as “a continuous endothelial membrane within brain microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells and perivascular astrocyte end-feet.” In the human, the BBB characterizes over 100 billion capillaries that cover a total length of around 400 miles and a surface area of 20 M 2 [12].…”

Section: Introductionmentioning

confidence: 99%

Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer

et al. 2019

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Brain tumors are characterized by very high mortality and, despite the continuous research on new pharmacological interventions, little therapeutic progress has been made. One of the main obstacles to improve current treatments is represented by the impermeability of the blood vessels residing within nervous tissue as well as of the new vascular net generating from the tumor, commonly referred to as blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB), respectively. In this review, we focused on established and emerging strategies to overcome the blood-brain barrier to increase drug delivery for brain cancer. To date, there are three broad strategies being investigated to cross the brain vascular wall and they are conceived to breach, bypass, and negotiate the access to the nervous tissue. In this paper, we summarized these approaches highlighting their working mechanism and their potential impact on the quality of life of the patients as well as their current status of development.

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Circumventing the blood–brain barrier

Cited by 8 publications

References 9 publications

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer

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