Circumscribed palmar hypokeratosis successfully treated with cryotherapy

Cerejeira, André; Gomes, Nuno; Amoedo, Patrícia; Costa‐Silva, Miguel; Azevedo, F

doi:10.5070/d3273052781

Cited by 2 publications

(2 citation statements)

References 4 publications

(6 reference statements)

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“…Parakeratosis, atypical keratinocytes, and cornoid lamella are usually absent, and the granular layer is slightly thinned. 2,18 Electron microscopic examination revealed different results such as vacuolation of corneocytes, decreased keratinocyte maturation, reduction of keratin bundles and keratohyalin granules, increased lipids in the horny layer, and degradation of desmosomes. 7 High-frequency ultrasonography and optical coherence tomography as noninvasive methods have also been used for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Circumscribed Palmar or Plantar Hypokeratosis and a Mini-review of the Literature

Atak,

Gonul,

Magsudova

et al. 2023

The American Journal of Dermatopathology

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Circumscribed palmar or plantar hypokeratosis (CPPH) is a new dermatologic disorder that firstly defined Pérez A et al in 2002. Since that time, further cases of CPPH have been reported by different authors in different countries. We report a 69-year-old Turkish woman who presented with asymptomatic, erythematous patches on the thenar region of the left hand and on the second left finger. Skin biopsy showed histological features of CPPH. In this article, it was emphasized that CPPH may be seen more frequently than expected and the clinical and pathological features of this disease with suspected malignant transformation should be known.

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Section: Discussionmentioning

confidence: 99%

A Case of Circumscribed Palmar or Plantar Hypokeratosis and a Mini-review of the Literature

Atak,

Gonul,

Magsudova

et al. 2023

The American Journal of Dermatopathology

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“…Topical steroids, calcipotriene, and 5-fluorouracil have been reported in the literature as potential treatment options with varying degrees of success. Other therapies often used in the setting of actinic damage, including cryotherapy and photodynamic therapy, may be considered depending on patient preference [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Circumscribed Palmar Hypokeratosis With Superimposed Actinic Keratosis

Aukerman¹,

Rao²,

Samiei³

et al. 2023

Cureus

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A man in his late 70s with a history of psoriasis and non-melanoma skin cancer presented with a progressive rash on his right thenar eminence. He first noticed it about one year ago. He denied any pruritus in the affected region but did note some overlying skin breakdown. He had used topical betamethasone and calcipotriene cream in the past with minimal improvement. Physical examination revealed a pink atrophic plaque with linear hyperkeratotic borders and central fissuring on the right thenar eminence extending into the first webspace. A shave biopsy revealed hypokeratosis with a rim of surrounding hyperkeratosis and associated parakeratosis, basal keratinocyte atypia, and lichenoid inflammation. These histopathological features were consistent with circumscribed palmar hypokeratosis and central actinic keratosis. Circumscribed palmar hypokeratosis is often considered a benign entity, but there have been reports suggesting an association with premalignancy. The decision was made to treat with 5-fluorouracil and calcipotriene cream twice daily for six weeks. At his two-month follow-up, he endorsed a robust reaction, which was further suggestive of premalignant change. He had a near-complete resolution of the rash. This case features circumscribed palmar hypokeratosis and suggests a novel treatment option for patients who develop concomitant actinic keratosis.

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Circumscribed palmar hypokeratosis successfully treated with cryotherapy

Cited by 2 publications

References 4 publications

A Case of Circumscribed Palmar or Plantar Hypokeratosis and a Mini-review of the Literature

A Case of Circumscribed Palmar or Plantar Hypokeratosis and a Mini-review of the Literature

Circumscribed Palmar Hypokeratosis With Superimposed Actinic Keratosis

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