Circumscribed palmar hypokeratosis on both hands: distinct keratin expression in multiple depressed lesions

Yasuda, Masahito; M, Abe; Suto, Mariko; Okada, Etsuko; Nagai, Yayoi; Tamura, Atsushi; Ishikawa, Osamu; Takahashi, Keiichi

doi:10.1111/j.1365-2133.2010.10042.x

Cited by 19 publications

(19 citation statements)

References 6 publications

(9 reference statements)

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“…20 The antipancytokeratin antibodies [AE1/AE3] were also elevated in another study of a patient with multiple lesions, with increased but variable expression of cytokeratin K16 depending of the site of the lesion; cytokeratin K9 levels were reduced but also showed variations depending on the site of the lesion. 31 In another report, cytokeratins K16 and K6 were weakly positive in a case of palmar hypokeratosis but negative in a case with plantar involvement. 26 In that same study, a reduction in the expression of cytokeratin K9 and of connexin Cx26 was detected in the plantar lesion, with no variation in the levels in the keratinocytes of the acrosyringia, and both markers were normal in a case with a palmar lesion.…”

Section: Immunohistochemistrymentioning

confidence: 88%

“…This is an acquired disorder that is more common in women, with a female to male ratio of 3.3 to 1, and it has been reported in patients aged between 42 and 84 years (mean age, 64.6 years) at the time of first consultation (one outlying case with lesions present from birth 44 was excluded from this calculation). In a large majority of cases (60 patients) the lesions were single; there were only 8 cases with 2 lesions, 3,11,13,20,21,27,29 one with 3 lesions, 31 and an exceptional case with 13 lesions in a linear distribution 21 (also excluded from the calculations as it was an outlier). Most lesions were located on the right palm, mainly affecting the thenar region (44 of 79 lesions).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Most lesions were located on the right palm, mainly affecting the thenar region (44 of 79 lesions). Lesions affecting the digits have been detected in isolated cases, 2,11,16,24,27,31,34,38,41 most commonly on the thumb, 2,11,16,27,31,34 but in 1 case on the dorsum of the index finger. 24 Lesions have also been reported on the palm, 26 on the dorsum or border of the feet, 24,34,44 and on the sole.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…HPV infection has subsequently been investigated on several occasions, with exhaustive analysis of high-and low-risk nongenital and genital HPV in some studies, 22 with negative results in all cases. 15,20,21,24,31,32,34,36,41 PCR analysis for bacterial genes has revealed no differences in the bacteria present on healthy skin and on the lesions. 20…”

Section: Polymerase Chain Reactionmentioning

confidence: 99%

“…11 Complete surgical excision of the altered skin can be an option in small lesions, but in larger lesions it can be associated with technical difficulties or a poor outcome. 7,9,15,21,31,41 Other therapeutic modalities are therefore preferred, as it is apparently a benign condition. Cryotherapy with liquid nitrogen was beneficial in 1 case, with no recurrence during follow-up of 1 year; in the opinion of those authors, 17 the efficacy of the technique may be due to the destruction of an abnormal clone of keratinocytes and repopulation with normal epidermal cells.…”

Section: Treatmentmentioning

confidence: 99%

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Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Urbina¹,

Pérez²,

Requena³

et al. 2014

Actas Dermo-Sifiliográficas (English Edition)

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This review of the literature on palmoplantar hypokeratosis, a process that was first indentified only 10 years ago, discusses the current state of our understanding, the therapeutic options available, and the debate about etiology. Forty-four publications reporting 69 cases were found. Palmar or plantar hypokeratosis occurs mainly in women (76.8%) and age at the time of a first visit to a physician ranges from 42 to 84 years. Most cases present between the ages of 51 and 70 years. The majority of patients have had solitary lesions usually located on the right palm, particularly in the regions of the thenar (in 44/79 lesions [55.7%]) or hypothenar eminences (in 11/79 lesions [13.9%]). In only 8 cases was there a history of prior trauma at the site. Studies using polymerase chain reaction techniques to identify human papillomavirus involvement were negative in most cases. These hypokeratotic lesions are localized epidermal depressions formed by an abrupt thinning of the stratum corneum, providing a singular histopathologic feature. This condition can currently be considered a localized keratinization disorder affecting zones where there is a thick stratum corneum. The precipitating cause is unknown and a definitive treatment remains to be found. The mechanism would be the localized failure of a clone of keratinocytes during differentiation toward normal palmoplantar hyperkeratinization. Palmas y plantas; Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripciónResumen Se revisa el estado actual de un nuevo proceso y los avances que han ido apareciendo en la literatura respecto a su estudio, posibilidades terapéuticas y controvertida etiología, tras ଝ Please cite this article as: Urbina F, Pérez A, Requena L, Rütten A. Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripción. Actas Dermosifiliogr. 2014;105:574---582.Palmar or Plantar Hypokeratosis 575 Palmoplantar; Queratinización; Queratinocito justo una década de su descripción inicial. Hemos encontrado 44 publicaciones al respecto, con 69 casos. Predomina en mujeres (76,8%), con edades entre los 42 y 84 años para toda la casuística en el momento de la consulta, siendo el rango más frecuente de aparición de las lesiones entre los 51 y 70 años. La gran mayoría de las veces fueron lesiones únicas y se localizaron predominantemente en la palma derecha, preferentemente en la región tenar, con 44/79 lesiones (55,7%) y luego en la hipotenar, con 11/79 lesiones (13,9%). Solo en 8 casos se obtuvo el antecedente de un traumatismo previo. Los estudios mediante PCR en búsqueda de papiloma virus humano han sido negativos la gran mayoría de las veces. Las lesiones consistieron en una depresión focalizada de la epidermis producida por una brusca disminución de espesor de la capa córnea, delimitando un singular concepto histolopatológico. En la actualidad puede ser considerada como un trastorno focalizado de la queratinización, que afecta zonas con un estrato córneo grueso, cuya c...

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Section: Immunohistochemistrymentioning

confidence: 88%