Circumcision and complications in patients with haemophilia in southern part of Turkey: Çukurova experience

Abstract

Circumcision is the oldest and most frequent surgical procedure in the world and especially in Turkey as is seen in the other Islamic countries because of religious and traditional pressures. In this study, we aim to report the experience of circumcision at Çukurova University in a total of 76 patients with haemophilia between 1990 and 2011. We retrospectively reviewed medical records of 69 haemophilia patients without inhibitors and seven haemophilia patients with inhibitors who had been circumcised. Before the year 2000, factor concentrates were given before and after circumcision for 6-7 days. After 2000, we used fibrin glue together with factor concentrates for only 3 days. By-passing agents were used for circumcision in haemophilia patients with inhibitors. Twelve of 69 patients without inhibitors were referred to our centre with bleeding after the circumcision before diagnosis of haemophilia. Nine of these twelve patients had severe life threatening bleeding and three of them had moderate bleeding. Sixty-four patients with haemophilia were circumcised in our centre under general anaesthesia except for three patients who were given local anaesthesia. Thirteen of 57 haemophilia patients (22.8%) without inhibitors had seven mild and six moderate bleeding complications. A few patients had significant bleeding, despite adequate factor replacement. Five of seven haemophilia patients with inhibitors had two moderate and three mild bleeding complications. Our experience showed that circumcision for patients with haemophilia should be carefully performed by surgeons together with paediatric haematologist, under appropriate conditions in haemophilia centres which has comprehensive coagulation lab.

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

“…Multiple additional papers address a variety of other topics and will be presented here in descending order of frequency (Table 5) for the use of fibrin sealant in the form of platelet-rich (PRP) or platelet-poor plasma (PPP) [203–213], hepatic surgery [214–222], neurosurgery [223–233], joint replacement orthopedic surgery [234–241], head and neck surgery [242–248], vascular surgery [61, 249–252], gastrointestinal surgery [253–258], gastroesophageal surgery [259–262], other orthopedic surgery [263–266], renal surgery [267–271], cardiac surgery [272–274], dental surgery [275–277], hemophilia [278–280], obstetrical and gynecological surgery [281–283], pancreatic surgery [284–286], transsphenoidal surgery [287–289], bariatric surgery [290, 291], drug delivery [292, 293], endoscopic polypectomy [294, 295], plastic surgery [83, 296], skull base reconstruction [297, 298], complications [299], trauma [300], and urology [301]. …”

Surgical interventions in childhood rare factor deficiencies

“…We did not find any ratio in the literature for the RFD group. This ratio for haemophilic patients was reported as 8.9% by Zü lfikar et al [26], as 6% by Yılmaz et al [28] and as 20.3% by Sasmaz et al [29].…”

“…Many studies exist on circumcision of haemophilic patients. An effort to establish a circumcision protocol may be observed particularly in the studies from our country [26][27][28][29]. Excluding circumcision of patients with factor XI deficiency, only anecdotal data are available regarding circumcision of RFD patients.…”

Outcome of harmonic scalpel circumcision in children with hemophilia

“…17 Boys with hemophilia are at risk of excessive bleeding during and after circumcision. 18 However, although many parents know this risk, they insist on circumcision due to religious and cultural reasons.…”