Circulatory heavy metals (cadmium, lead, mercury, and chromium) inversely correlate with plasma GST activity and GSH level in COPD patients and impair NOX4/Nrf2/GCLC/GST signaling pathway in cultured monocytes

Gogoi, Kabita; Manna, Prasenjit; Dey, Tushar Kanti; Kalita, Jatin; Unni, B. G.; Ozah, Dibyajyoti; Baruah, Pranab Kumar

doi:10.1016/j.tiv.2018.10.010

Cited by 43 publications

(30 citation statements)

References 40 publications

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“…Pb exposure is known to play a causal role in respiratory disease ( Boskabady et al, 2018 ). Heavy metals including lead were found to be higher in patients with COPD, being interrelated with pulmonary dysfunction and antioxidant activity ( Gogoi et al, 2019 ). Correspondingly, soil and water lead distribution was shown to be associated with patterns of respiratory disease burden in Iran ( Ghias, Mohammadzadeh, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for CO rona VI rus D isease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.

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Section: Introductionmentioning

confidence: 99%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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“…Based on these findings, we can hypothesize that the expressions of NOX4 and Nrf2 are positively correlated, while in some particular experiments, the Nrf2 and NOX4 expressions are negatively correlated (Gogoi et al, 2019). Toxic substances, such as silicon or circulatory heavy metals, inactivate Nrf2, whereas the level of NOX4…”

Section: Enzymatic Properties Regulation and Signaling Pathways Asmentioning

confidence: 92%

“…increases (Feng et al, 2019;Gogoi et al, 2019;Peng et al, 2019). In contrast, protective substances such as ethyl acetate extract of salvia miltiorrhiza and the major constituent tanshinone IIA contain many lipophilic diterpenoid quinones with anti-inflammatory and antioxidative effects (Feng et al, 2019;Gogoi et al, 2019;Peng et al, 2019).…”

Section: Enzymatic Properties Regulation and Signaling Pathways Asmentioning

confidence: 99%

“…The relationship between Nrf2 and NOX4 has not been explicitly described (Feng et al, 2019;Gogoi et al, 2019;Peng et al, 2019).…”

Section: Enzymatic Properties Regulation and Signaling Pathways Asmentioning

confidence: 99%

“…NOX4 was discovered in the kidney (Geiszt, Kopp, Varnai, & Leto, 2000) and is also expressed in the respiratory system, such as in the pulmonary artery endothelium (Zelko & Folz, 2015), pulmonary artery smooth muscle cells (PASMCs; Sturrock et al, 2006), and myofibroblasts (Tsubouchi et al, 2017). NOX4 is involved in various respiratory diseases, such as ARDS (Palumbo et al, 2017), COPD (Gogoi et al, 2019), and pulmonary fibrosis (Carnesecchi et al, 2011). In this review, we introduce the structure and enzymatic properties of NOX4, summarize the expression regulation of this protein, and discuss the role of NOX4 in several respiratory system diseases.…”

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confidence: 99%

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The role of NOX4 in pulmonary diseases

Feng

et al. 2020

Journal Cellular Physiology

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Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial cells in the respiratory system. NOX4 has unique characteristics, and is a constitutively active enzyme that primarily produces hydrogen peroxide. The signaling pathways associated with NOX4 are complicated. Negative and positive feedback play significant roles in regulating NOX4 expression. The role of NOX4 is controversial because NOX4 plays a protective or damaging role in different respiratory diseases. This review summarizes the structure, enzymatic properties, regulation, and signaling pathways of NOX4. This review then introduces the roles of NOX4 in different diseases in the respiratory system, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis.

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