2020
DOI: 10.1002/jcp.30005
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The role of NOX4 in pulmonary diseases

Abstract: Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a subtype of the NOX family, which is mainly expressed in the pulmonary vasculature and pulmonary endothelial cells in the respiratory system. NOX4 has unique characteristics, and is a constitutively active enzyme that primarily produces hydrogen peroxide. The signaling pathways associated with NOX4 are complicated. Negative and positive feedback play significant roles in regulating NOX4 expression. The role of NOX4 is controversial because NOX4 p… Show more

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Cited by 21 publications
(20 citation statements)
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References 107 publications
(212 reference statements)
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“…Reactive oxygen species (ROS) related factor NADPH oxidase 4 (Nox4) has been evidenced to promote pulmonary fibrosis. Nox4 expression is markedly increased in the lung fibroblasts from IPF patients and BLM-induced pulmonary fibrosis mice [ 49 , 50 ]. In the fibrotic lung, increased Nox4 induces lung fibroblasts to transform into senescent and apoptosis-resistant phenotype, aggravating pulmonary fibrosis.…”
Section: The Mechanism Underlying Progressive Development Of Irreversible Pulmonary Fibrosismentioning
confidence: 99%
“…Reactive oxygen species (ROS) related factor NADPH oxidase 4 (Nox4) has been evidenced to promote pulmonary fibrosis. Nox4 expression is markedly increased in the lung fibroblasts from IPF patients and BLM-induced pulmonary fibrosis mice [ 49 , 50 ]. In the fibrotic lung, increased Nox4 induces lung fibroblasts to transform into senescent and apoptosis-resistant phenotype, aggravating pulmonary fibrosis.…”
Section: The Mechanism Underlying Progressive Development Of Irreversible Pulmonary Fibrosismentioning
confidence: 99%
“…NOX4 was first discovered in the kidney, but is also highly expressed in pulmonary vasculature and endothelial and plays an important role in respiratory diseases such as pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, pulmonary vascular diseases, and acute respiratory distress syndrome [ 153 ]. NOX4 has also been shown to be expressed in Jurkat T cells.…”
Section: Other Nadph Oxidase Family Large Transmembrane Catalytic Subunitsmentioning
confidence: 99%
“…This NADPH oxidase, in contrast to Nox2, generates H 2 O 2 and not O 2 − [128]. Although Nox4-produced H 2 O 2 is an important second messenger, when its expression is induced or its function is activated, it also contributes to lung injury [124]. [114]).…”
Section: Oxidative Stress In Pathogenesis Of Ards/alimentioning
confidence: 99%