The role of NOX4 in pulmonary diseases

Li, Ziming; Xu, Sheng‐Ya; Feng, Yi‐Zhuo; Cheng, Yu‐Rui; Xiong, Jian‐Bing; Zhou, Yong; Guan, Cha‐Xiang

doi:10.1002/jcp.30005

Cited by 22 publications

(21 citation statements)

References 107 publications

(212 reference statements)

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“…Reactive oxygen species (ROS) related factor NADPH oxidase 4 (Nox4) has been evidenced to promote pulmonary fibrosis. Nox4 expression is markedly increased in the lung fibroblasts from IPF patients and BLM-induced pulmonary fibrosis mice [ 49 , 50 ]. In the fibrotic lung, increased Nox4 induces lung fibroblasts to transform into senescent and apoptosis-resistant phenotype, aggravating pulmonary fibrosis.…”

Section: The Mechanism Underlying Progressive Development Of Irreversible Pulmonary Fibrosismentioning

confidence: 99%

Irreversibility of Pulmonary Fibrosis

Yu¹,

Tang²

2022

Aging and disease

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Pulmonary fibrosis, a kind of terminal pathological changes in the lung, is caused by aberrant wound healing, deposition of extracellular matrix (ECM), and eventually replacement of lung parenchyma by ECM. Pulmonary fibrosis induced by acute lung injury and some diseases is reversible under treatment. While idiopathic pulmonary fibrosis is persistent and irreversible even after treatment. Currently, the pathogenesis of irreversible pulmonary fibrosis is not fully elucidated. The known factors associated with the development of irreversible fibrosis include apoptosis resistance of (myo)fibroblasts, dysfunction of pulmonary vessel, cell mitochondria and autophagy, aberrant epithelia hyperplasia and lipid metabolism disorder. In this review, other than a brief introduction of reversible pulmonary fibrosis, we focus on the underlying pathogenesis of irreversible pulmonary fibrosis from the above aspects as well as preclinical disease models, and also suggest directions for future studies.

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Section: The Mechanism Underlying Progressive Development Of Irreversible Pulmonary Fibrosismentioning

confidence: 99%

Irreversibility of Pulmonary Fibrosis

Yu¹,

Tang²

2022

Aging and disease

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“…NOX4 was first discovered in the kidney, but is also highly expressed in pulmonary vasculature and endothelial and plays an important role in respiratory diseases such as pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, pulmonary vascular diseases, and acute respiratory distress syndrome [ 153 ]. NOX4 has also been shown to be expressed in Jurkat T cells.…”

Section: Other Nadph Oxidase Family Large Transmembrane Catalytic Subunitsmentioning

confidence: 99%

The role of NADPH oxidases in infectious and inflammatory diseases

Taylor

Tse

2021

Redox Biology

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Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an electron donor. There are seven enzymes in the NOX family: NOX1-5 and dual oxidase (DUOX) 1–2. NOX enzymes in humans play important roles in diverse biological functions and vary in expression from tissue to tissue. Importantly, NOX2 is involved in regulating many aspects of innate and adaptive immunity, including regulation of type I interferons, the inflammasome, phagocytosis, antigen processing and presentation, and cell signaling. DUOX1 and DUOX2 play important roles in innate immune defenses at epithelial barriers. This review discusses the role of NOX enzymes in normal physiological processes as well as in disease. NOX enzymes are important in autoimmune diseases like type 1 diabetes and have also been implicated in acute lung injury caused by infection with SARS-CoV-2. Targeting NOX enzymes directly or through scavenging free radicals may be useful therapies for autoimmunity and acute lung injury where oxidative stress contributes to pathology.

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“…This NADPH oxidase, in contrast to Nox2, generates H 2 O 2 and not O 2 − [128]. Although Nox4-produced H 2 O 2 is an important second messenger, when its expression is induced or its function is activated, it also contributes to lung injury [124]. [114]).…”

Section: Oxidative Stress In Pathogenesis Of Ards/alimentioning

confidence: 99%

Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment—From Mice to Men

et al. 2022

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Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medical need for a new therapeutic concept. One reason for a missing etiologic therapy strategy is the multifactorial origin of ARDS, which leads to a large heterogeneity of patients. This review summarizes the various kinds of ARDS onset with a special focus on the role of reactive oxygen species (ROS), which are generally linked to ARDS development and progression. Taking a closer look at the data which already have been established in mouse models, this review finally proposes the translation of these results on successful antioxidant use in a personalized approach to the ICU patient as a potential adjuvant to standard ARDS treatment.

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The role of NOX4 in pulmonary diseases

Cited by 22 publications

References 107 publications

Irreversibility of Pulmonary Fibrosis

Irreversibility of Pulmonary Fibrosis

The role of NADPH oxidases in infectious and inflammatory diseases

Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment—From Mice to Men

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