Circulatory Effects of Prolonged Hypoxia in Normal and Hemorrhaged Dogs

Hayashi, Toshimitsu; Veragut, U.P.; Bailey, Leonard L.; Smith, Louis L.

doi:10.1001/archsurg.1969.01340170097023

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…These losses were immediately evaluated and appeared to be associated with a progressive decline in the hemoglobin concentration and oxygen contents. Note that there was no septicemia as a possible cause for low total systemic resistance (9) and that the arterial P 0 2 and PC02 were about 50 and 25 Torr, respectively, which could also partly explain the decrease in the arterial pressure (19) and heart rate (8). Also note that the control heart rate values were rather high.…”

Section: Discussionmentioning

confidence: 86%

24-Hour Extracorporeal Membrane Oxygenation in the Hypoxic Dog: Hemodynamics and Pulmonary Gas Exchange

G¹,

P²,

Grimbert³

et al. 1979

Eur Surg Res

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Hemodynamic and pulmonary gas exchange values were investigated during 24-hour extracorporeal membrane oxygenation performed on 7 anesthetized dogs subjected to alveolar hypoxia. The chief effects of extracorporeal membrane oxygenation were demonstrated. The duration of the extracorporeal membrane oxygenation was associated with a progressive decline in the systemic arterial pressure and heart rate and a progressive increase in the pulmonary blood flow rate. Left-ventricular stroke work remained constant. The sum of the pulmonary and extracorporeal oxygen uptakes showed no change in spite of large variations in pulmonary flow rate.

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Section: Discussionmentioning

confidence: 86%

24-Hour Extracorporeal Membrane Oxygenation in the Hypoxic Dog: Hemodynamics and Pulmonary Gas Exchange

G¹,

P²,

Grimbert³

et al. 1979

Eur Surg Res

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Der Einfluß von Schlafmitteln auf die Entwicklung der morphologischen und biochemischen Wundreaktionen

et al. 1979

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The influence of hypnotics (barbital and carbromal) on the development of the early wound reactions in mechanically injured skin of guinea pigs was investigated: 1) The cellular reactions in incised wounds were retarded after moderate intoxication by hypnotics (300 mg/kg barbital; 3 g/kg carbromal). The histomorphological changes in wounds were inhibited by carbromal twice as much as by barbital. The hitherto published investigations had not shown any retardation of the early cellular inflammation by weakening influences such as loss of blood or alcohol without symptoms of shock (Berg et al., 1977) or local disturbances by acids and bases (Kampmann et al., 1978). 2). A moderate delay of the activity of structure bound enzymes was found in barbital intoxication, a stronger restriction under the influence of carbromal. 3) After barbital intoxication significant elevation of histamine or serotonin in wounds was not seen. Under the influence of carbromal there was also no increase of histamine but an increase of serotonin. Thus, although the cellular reactions seem to be the most reliable indicator among the methods for the determinations of wound age under devitalizing influences, their value is reduced in cases of intoxications by hypnotics needing treatment. Possible pathophysiological connections of the alterations of morphological and biochemical wound reaction with shock are discussed.

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Circulatory Effects of Prolonged Hypoxia in Normal and Hemorrhaged Dogs

Cited by 2 publications

References 18 publications

24-Hour Extracorporeal Membrane Oxygenation in the Hypoxic Dog: Hemodynamics and Pulmonary Gas Exchange

24-Hour Extracorporeal Membrane Oxygenation in the Hypoxic Dog: Hemodynamics and Pulmonary Gas Exchange

Der Einfluß von Schlafmitteln auf die Entwicklung der morphologischen und biochemischen Wundreaktionen

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