24-Hour Extracorporeal Membrane Oxygenation in the Hypoxic Dog: Hemodynamics and Pulmonary Gas Exchange

Abstract

Hemodynamic and pulmonary gas exchange values were investigated during 24-hour extracorporeal membrane oxygenation performed on 7 anesthetized dogs subjected to alveolar hypoxia. The chief effects of extracorporeal membrane oxygenation were demonstrated. The duration of the extracorporeal membrane oxygenation was associated with a progressive decline in the systemic arterial pressure and heart rate and a progressive increase in the pulmonary blood flow rate. Left-ventricular stroke work remained constant. The sum of the pulmonary and extracorporeal oxygen uptakes showed no change in spite of large variations in pulmonary flow rate.

Peripheral circulatory effects of pump perfusion on cat skeletal muscle with and without prostacyclin

“…Clinical as well as experimental experiences strongly indicate that the use of blood circulation outside the body through artificial tubes -especially when using a pump in the circulatory shunt system -influences normal haemodynamics. This is supported by several studies showing the interference with both systemic (Fox & Henderson 1993) and pulmonary circulation (Michalot et al 1979, Dauber et al 1993, Fessatidis et al 1994. The marked blood pressure fall and loss of fluid into the interstitial space routinely seen after the starting of the heart-lung machine during open heart surgery clearly illustrate the existence of such an interference (Christakis et al 1994, Smith et al 1987, Dauber et al 1993.…”