Circulation of human influenza viruses and emergence of Oseltamivir-resistant A(H1N1) viruses in Cameroon, Central Africa

Njouom, Richard; Sadeuh, Serge Alain; Noah, Dominique Noah; Gregory, Victoria; Collins, Patrick J.; Cappy, Pierre; Hay, Alan J.; Rousset, Dominique

doi:10.1186/1471-2334-10-56

Cited by 25 publications

(36 citation statements)

References 13 publications

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“…These studies reported levels of positive influenza A virus seasonal strain detection ranging from 25% in Peru to 40% in Greece (18,22). Our level of influenza A virus detection (33.1%) appears to be in agreement with previous published worldwide studies (17,22,30,41,42 Interestingly, the combination of two RT-PCR DNA microarray systems allowed us to detect not only influenza A virus strains but also 17 other common or newly discovered respiratory viruses in the same sample. This approach demonstrated that HRV and PIV were important causes of ILI, with 25 and 10.5% prevalence, respectively (Fig.…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Rapid Detection of Respiratory Tract Viral Infections and Coinfections in Patients with Influenza-Like Illnesses by Use of Reverse Transcription-PCR DNA Microarray Systems

et al. 2010

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Section: Discussionsupporting

confidence: 79%

“…1). Numerous previous studies detected the presence of influenza viruses in the respiratory tracts of ILI patients by use of real-time RT-PCR systems during 2007 to 2008 (18,30,41,42). These studies reported levels of positive influenza A virus seasonal strain detection ranging from 25% in Peru to 40% in Greece (18,22).…”

Section: Discussionmentioning

confidence: 93%

Rapid Detection of Respiratory Tract Viral Infections and Coinfections in Patients with Influenza-Like Illnesses by Use of Reverse Transcription-PCR DNA Microarray Systems

et al. 2010

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“…4 Apart from the elderly, young children are at risk to develop severe disease often associated with complications. Children also serve as sources of secondary infections in households and communities.…”

Section: -3mentioning

confidence: 99%

“…[1][2][3] Influenza A (H1N1), A (H3N2), and B viruses have been found circulating in the human population of Central Africa, with first evidence of the emergence of oseltamivir-resistant A (H1N1) strains. 4 Apart from the elderly, young children are at risk to develop severe disease often associated with complications. Children also serve as sources of secondary infections in households and communities.…”

mentioning

confidence: 99%

Influenza A and Parvovirus B19 Seropositivity Rates in Gabonese Infants

Gabor

Schwarz

Esen

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Clinical and epidemiological data from Central Africa on influenza A and parvovirus B19 infections are limited. We analyzed 162 blood samples of infants 3, 9, 15, and 30 months of age for IgG antibodies against both pathogens. Antibody responses were 0, 3.7%, 12.3%, and 20.4% against influenza A; and 1.2%, 2.5%, 3.1%, and 9.3% against parvovirus B19, respectively. Seropositivity rates were 89.5 (95% confidence interval [CI]: 59-120.1) and 38.2 (95% CI: 18.9-57.6)/1,000 person-years at risk for influenza A and parvovirus B19, respectively. Our data add to the understanding of the epidemiology of both conditions.Over the past decades, combating major infectious diseases in Africa such as human immunodeficiency virus (HIV), tuberculosis, and malaria rightfully enjoyed priority; other causes of fever were not in the focus of medical research. Consequently, clinical and epidemiological data on viruses such as influenza virus A and parvovirus B19 from (among other regions) Central Africa is limited, particularly for young children. However, the policy of administering an artemisinin combination therapy after confirmation of malaria by rapid diagnostic testing/randomized controlled trial (RDT-RCT) has led to the recognition that febrile disease episodes in patients suspected of malaria on clinical grounds are often a result of other causes. The burden of influenza in sub-Saharan Africa (sSA) is mainly assessed by passive case detection on hospital admission or at outpatient clinics and thus probably often yields underestimates. Available data indicate that the burden of influenza is comparable to other areas in the world. 1-3Influenza A (H1N1), A (H3N2), and B viruses have been found circulating in the human population of Central Africa, with first evidence of the emergence of oseltamivir-resistant A (H1N1) strains. 4 Apart from the elderly, young children are at risk to develop severe disease often associated with complications. Children also serve as sources of secondary infections in households and communities. In our study area, van Riet and colleagues 5 found pre-vaccination antibodies against A and B influenza viruses, with those against A-H3N2 being highest. The epidemiology of parvovirus B19 is by and large unknown in sSA. In Central Africa, infection with homologues of human parvoviruses in primates is common, thus constituting a potential reservoir 6 ; for parvovirus 4, positive antibodies have been found in 35% of the adult population in the Democratic Republic of Congo.7 Although infections in immune-competent individuals are usually mild, parvovirus B19 can cause increased morbidity and even mortality in a population with a high prevalence of hematologic disorders, chronic parasitic infections, and HIV. [8][9][10][11] In this study, we assessed immunoglobulin G (IgG) serum antibodies against influenza A and parvovirus B19 in young Gabonese children to estimate the potential burden of disease in early childhood. were the same for all 1.189 IPTi-infants. Selection criteria for the 162 infants descr...

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“…Very recently however, samples from patients living with influenza-like illness in Yaounde, Cameroon were analyzed with various techniques including real time reverse transcription-polymerase chain reaction (RT-PCR) thus allowing the detection and subtyping of influenza A (H1N1 and H3N2) and B viruses from these patients [127]. Because of the H1N1 influenza A pandemic, Cameroon entered in a global surveillance network and received a laboratory equipped with a robust PCR platform for diagnosing influenza viruses in remote settings [128].…”

Section: Influenza Virusmentioning

confidence: 99%

Application of PCR Technologies to Humans, Animals, Plants and Pathogens from Central Africa

Odile¹,

Migot-Nabias²,

Born³

et al. 2012

Polymerase Chain Reaction

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Circulation of human influenza viruses and emergence of Oseltamivir-resistant A(H1N1) viruses in Cameroon, Central Africa

Cited by 25 publications

References 13 publications

Rapid Detection of Respiratory Tract Viral Infections and Coinfections in Patients with Influenza-Like Illnesses by Use of Reverse Transcription-PCR DNA Microarray Systems

Rapid Detection of Respiratory Tract Viral Infections and Coinfections in Patients with Influenza-Like Illnesses by Use of Reverse Transcription-PCR DNA Microarray Systems

Influenza A and Parvovirus B19 Seropositivity Rates in Gabonese Infants

Application of PCR Technologies to Humans, Animals, Plants and Pathogens from Central Africa

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