Circulation microRNA expression profiles in patients with complete responses to chemoradiotherapy in nasopharyngeal carcinoma

Wardana, Tirta; Chasanah, Siti Nur; Oktriani, Risky; Herawati, Cita; Anwar, Sumadi Lukman; Astuti, Indwiani; Haryana, Sofia Mubarika

doi:10.1016/j.ncrna.2022.09.005

Cited by 4 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR‐221‐3p was found to be downregulated in NPC following chemotherapy and radiotherapy, which negatively affected apoptosis and survival. Angiogenesis, cell proliferation, inflammatory response, necrosis, apoptosis, cell viability, and migration and invasion were some of the mechanisms identified in carcinoma cell lines 106 . Also, the study reported convincing proof for a circ_0002538/, miR‐589‐5p/RPGR axis dysregulated in NPC compared to non‐cancer cell lines.…”

Section: Roles Of Cerna Network and Virus‐related Cancersmentioning

confidence: 69%

“…Angiogenesis, cell proliferation, inflammatory response, necrosis, apoptosis, cell viability, and migration and invasion were some of the mechanisms identified in carcinoma cell lines. 106 Also, the study reported convincing proof for a circ_0002538/, miR-589-5p/RPGR axis dysregulated in NPC compared to non-cancer cell lines. This study showed that circ_0002538 expression leads to miR-589-5p downregulation, which controls RPGR expression.…”

Section: Nasopharyngeal Carcinomamentioning

confidence: 82%

See 1 more Smart Citation

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Kamali,

Salehi,

Mostafavi

et al. 2024

Reviews in Medical Virology

View full text Add to dashboard Cite

A significant portion of human cancers are caused by oncoviruses (12%–25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)‐mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non‐coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus‐induced reprogramming of host circRNA‐mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.

show abstract

Section: Roles Of Cerna Network and Virus‐related Cancersmentioning

confidence: 69%

Section: Nasopharyngeal Carcinomamentioning

confidence: 82%

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Kamali,

Salehi,

Mostafavi

et al. 2024

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

“…Moreover, miRNAs have been recognized as future biomarkers in various diseases [11][12][13][14][15][16] including PAH [17]. Patients with PAH associated with CHD have been shown to exhibit the altered expression of several miRNAs, and this variation is correlated with disease severity and prognosis [18,19].…”

Section: Review Articlementioning

confidence: 99%

Recent progress in the roles of microRNAs in pulmonary arterial hypertension associated with congenital heart disease

Siregar,

Hartopo,

Mubarika

2024

Narra J

View full text Add to dashboard Cite

Research on noncoding RNA, particularly microRNAs (miRNAs), is growing rapidly. Advances in genomic technologies have revealed the complex roles of miRNAs in pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD). It has been demonstrated that the progression of PAH associated with CHD is characterized by particular dysregulation of miRNAs and is related to cardiovascular remodeling, cell death, and right ventricle dysfunction. This review provides a comprehensive overview of the current state of knowledge regarding the involvement of miRNAs in the pathogenesis and progression of PAH associated with CHD. We commence by explaining the process of miRNA synthesis and its mode of action, as well as the role of miRNA in PAH associated with CHD. Moreover, the article delves into current breakthroughs in research, potential clinical implications, and prospects for future investigations. The review provides the insight into novel approaches for diagnosis, prognosis, and therapy of PAH associated with CHD.

show abstract

“…[ [21][22][23] miR-141-3p Enhances the proliferation, invasion and migration NPC cells by promoting vimentin expression Targets NME1 which leads to the activation of p-Akt promoting metastases [24][25][26][27] miR-205…”

Section: Type Mirna Npc Related Events Referencesmentioning

confidence: 99%

Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A review

S. M. N. Mydin,

Azlan,

Okekpa

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

MicroRNAs (miRNA) are small and conserved noncoding RNA molecules that regulate gene expression at the posttranscriptional level. These groups of RNAs are crucial in various cellular processes, especially in mediating disease pathogenesis, particularly cancer. The dysregulation of miRNAs was reported in many cancer types, including nasopharyngeal cancer (NPC), which is a malignant tumor of the nasopharynx. In this review, miRNAs involvement in crucial signaling pathways associated with NPC such as PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F was investigated. miRNAs could function as tumor suppressor‐miR or onco‐miR in NPC profoundly influenced cell cycle, apoptosis, proliferation, migration, and metastasis. This comprehensive review of current literature provided a thorough profile of miRNAs and their interplay with the aforementioned signaling pathways in NPC. Understanding these molecular interactions could remarkably impact the diagnosis, prognosis, and therapeutic strategies for NPC.

show abstract

Circulation microRNA expression profiles in patients with complete responses to chemoradiotherapy in nasopharyngeal carcinoma

Cited by 4 publications

References 52 publications

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Recent progress in the roles of microRNAs in pulmonary arterial hypertension associated with congenital heart disease

Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A review

Contact Info

Product

Resources

About