Circulating Wnt inhibitory factor 1 levels are associated with development of cardiovascular disease

Ress, Claudia; Paulweber, M.; Goebel, Georg; Willeit, Karin; Rufinatscha, Kerstin; Strobl, Anna; Salzmann, Karin; Kedenko, Ludmilla; Tschoner, Alexander; Staudacher, G; Iglseder, Bernhard; Tilg, Herbert; Paulweber, Bernhard; Kaser, Susanne

doi:10.1016/j.atherosclerosis.2018.03.045

Cited by 22 publications

(18 citation statements)

References 38 publications

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“…Clinical studies aiming at the impact of Dkk-1 on atherosclerosis have also generated controversial results, showing either direct or inverse correlations (table 1). Gaudio et al [44]. On the contrary, more recent studies have suggested that Dkk-1 is inversely associated with CAD or atherosclerosis.…”

Section: Clinical Evidence For the Role Of Wnt Signalling In Coronary Artery Diseasementioning

confidence: 94%

The role of Wnt signalling in development of coronary artery disease and its risk factors

2020

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The Wnt signalling pathways are composed of a highly conserved cascade of events that govern cell differentiation, apoptosis and cell orientation. Three major and distinct Wnt signalling pathways have been characterized: the canonical Wnt pathway (or Wnt/β-catenin pathway), the non-canonical planar cell polarity pathway and the non-canonical Wnt/Ca 2+ pathway. Altered Wnt signalling pathway has been associated with diverse diseases such as disorders of bone density, different malignancies, cardiac malformations and heart failure. Coronary artery disease is the most common type of heart disease in the United States. Atherosclerosis is a multi-step pathological process, which starts with lipid deposition and endothelial cell dysfunction, triggering inflammatory reactions, followed by recruitment and aggregation of monocytes. Subsequently, monocytes differentiate into tissue-resident macrophages and transform into foam cells by the uptake of modified low-density lipoprotein. Meanwhile, further accumulations of lipids, infiltration and proliferation of vascular smooth muscle cells, and deposition of the extracellular matrix occur under the intima. An atheromatous plaque or hyperplasia of the intima and media is eventually formed, resulting in luminal narrowing and reduced blood flow to the myocardium, leading to chest pain, angina and even myocardial infarction. The Wnt pathway participates in all different stages of this process, from endothelial dysfunction to lipid deposit, and from initial inflammation to plaque formation. Here, we focus on the role of Wnt cascade in pathophysiological mechanisms that take part in coronary artery disease from both clinical and experimental perspectives.

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Section: Clinical Evidence For the Role Of Wnt Signalling In Coronary Artery Diseasementioning

confidence: 94%

The role of Wnt signalling in development of coronary artery disease and its risk factors

2020

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“…Wnt signaling is involved in atherosclerotic plaque formation directly and indirectly by modulating cardiovascular risk factors. Baseline systemic SFRP1 levels are significantly higher in patients with cardiovascular events compared to healthy controls ( 159 ). SFRP3 is a predictor of all-cause mortality and re-hospitalization due to stroke in a large population of acute coronary syndrome patients with long-term follow-up.…”

Section: The Effect Of Sfrps On Cardiovascular Diseasementioning

confidence: 99%

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

et al. 2021

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Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.

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“…The development of vascular calcification and arterial stiffness leads to an increased incidence of cardiovascular disease. Sclerostin is a soluble inhibitor of Wnt signaling pathway and Wnt signaling pathway is thought to be involved in the development of vascular calcification and cardiovascular disease [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Sclerostin is an independent risk factor for all-cause mortality in kidney transplant recipients

et al. 2020

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Background Sclerostin is a hormone contributing to the bone-vascular wall cross talk and has been implicated in cardiovascular events and mortality in patients with chronic kidney disease (CKD). We analyzed the relationship between sclerostin and mortality in renal transplant recipients. Methods 600 stable renal transplant recipients (367men, 233 women) were followed for all-cause mortality for 3 years. Blood and urine samples for analysis and clinical data were collected at study entry. We performed Kaplan–Meier survival analysis and Cox regression models considering confounding factors such as age, eGFR, cold ischemia time, HbA1c, phosphate, calcium, and albumin. Optimal cut-off values for the Cox regression model were calculated based on ROC analysis. Results Sixty-five patients died during the observation period. Nonsurvivors (n = 65; sclerostin 57.31 ± 30.28 pmol/L) had higher plasma sclerostin levels than survivors (n = 535; sclerostin 47.52 ± 24.87 pmol/L) (p = 0.0036). Kaplan–Meier curve showed that baseline plasma sclerostin concentrations were associated with all-cause mortality in stable kidney transplant recipients (p = 0.0085, log-rank test). After multiple Cox regression analysis, plasma levels of sclerostin remained an independent predictor of all-cause mortality (hazard ratio, 1.011; 95% CI 1.002–1.020; p = 0.0137). Conclusions Baseline plasma sclerostin is an independent risk factor for all-cause mortality in patients after kidney transplantation.

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Circulating Wnt inhibitory factor 1 levels are associated with development of cardiovascular disease

Cited by 22 publications

References 38 publications

The role of Wnt signalling in development of coronary artery disease and its risk factors

The role of Wnt signalling in development of coronary artery disease and its risk factors

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Sclerostin is an independent risk factor for all-cause mortality in kidney transplant recipients

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