Circulating vitamin D levels are associated with the presence and severity of coronary artery disease but not peripheral arterial disease in patients undergoing coronary angiography

Increased Bone Resorption: A Possible Pathophysiological Link Between Hypovitaminosis D and Peripheral Arterial Disease

“…44 In a recent study, Liew et al found an association between serum vitamin D levels and the presence and severity of coronary artery disease but failed to find a relationship between vitamin D deficiency and PAD. 45 Nevertheless, as suggested by the authors, the relatively small number of patients with pathological ABI recruited to the study did not allow a definitive conclusion to be made. 45 The 2014 report of the USA Agency for Healthcare Research and Quality did not consider PAD among potential health outcomes of hypovitaminosis D, owing to the lack of large studies in these patients.…”

“…45 Nevertheless, as suggested by the authors, the relatively small number of patients with pathological ABI recruited to the study did not allow a definitive conclusion to be made. 45 The 2014 report of the USA Agency for Healthcare Research and Quality did not consider PAD among potential health outcomes of hypovitaminosis D, owing to the lack of large studies in these patients. 46 The present findings support the hypothesis that increased bone turnover, expressed by high sCTX levels, may represent a possible link between hypovitaminosis D and PAD, even if a definitive causeeeffect relationship cannot be found between these two conditions.…”

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“…[9,10] The serum BTMs are indication of recent bone remodeling stage. Many previous studies had been reported that osteocalcin…”

“…[21,22] Study on the multi-centers from 5 provinces of Thailand which cover all region of Thailand except southern area which represented calcidiol level of Thai premenopausal women was 29.09 (±0.42) ng/ml, and with the cut point of <or = 35 ng/ml; the prevalence of vitamin D insufficiency was 77.81%, and parathyroid hormone (PTH), and bone resorption markers were trended to increase. [9] Thai premenopausal women were commonly hypovitaminosis D and low level of 25-(OH)D and risk will be increased in elderly women who are living in the rural area. [22] The prevalence of vitamin D insufficiency among elderly males was 13.6%, while the BTM (P-CTX and PINP) levels were in the normal Thai reference range.…”

The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

“…Whether vitamin D deficiency or insufficiency is a risk factor for PAD is currently unclear. Some studies have reported that low levels of circulating 25(OH)D are associated with PAD [10][11][12][13] while others have not [2,14,15]. Furthermore, a recent study that followed up 1568 community-dwelling elderly participants for 4.4 years concluded that baseline vitamin D did not predict the onset of PAD among the 371 subjects who eventually developed the disease [16].…”