Circulating tumour cells in gastrointestinal cancers: food for thought?

Asawa, Simran; Nüesch, Manuel; Gvozdenovic, Ana; Aceto, Nicola

doi:10.1038/s41416-023-02228-8

Cited by 5 publications

(3 citation statements)

References 137 publications

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“…About thirty years ago, pioneering studies used different murine models to elucidate the reasons for this organ-specific metastatic process [2]. More recently, new strategies with simple biomaterial-or microfluidics-based co-cultures have tried to summarize this complex microenvironment to better understand the interactions between cancer cells and the stroma at the metastatic site [3].…”

Section: Introductionmentioning

confidence: 99%

“…As the main contributor is the portal vein [6], the hepatic sinusoids are directly exposed to CTCs emerging from primary malignant tumors developing in the gastrointestinal tract. The fenestrated vasculature that characterizes the liver [5] also explains why CTCs easily exit the vessels and preferentially colonize this organ [3]. The different steps of this colonization have been remarkably deciphered and illustrated, emphasizing the role of complex interactions between tumor cells and a great diversity of highly specialized resident cells, among which hepatocytes play an important role [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Pouliquen

2024

Explor Dig Dis

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The liver, characterized by a unique metabolic and immunosuppressive environment, is also the organ to which invasive malignant cells of many different cancer types most frequently metastasize. The reasons for this organ-specific metastatic process have been investigated for decades. This review first provides an overview of recent breakthroughs in this field, introducing intercellular communication between circulating tumor cells and the heterogeneous cell populations of the liver, and modifications to the extracellular matrix (ECM). Subsequently, to improve the understanding of the molecular mechanisms involved in the metastasis of colorectal cancer to the liver, the second leading cause of cancer-related mortality, the recent literature on this question was analyzed. Among the various parameters involved, the mechanisms behind the activation of hepatic stellate cells, proteins inducing ECM remodeling, specific genomic features of liver metastases, metabolic rewiring, and characteristics of stromal-enriched microenvironments were discussed. To provide more insights into the molecular determinants of liver metastatic colonization, important findings reported on a set of mitochondrial proteins were addressed, the relative abundance of which changed in the liver during the progression stage of an aggressive experimental model of peritoneal malignant mesothelioma in immunocompetent rats. Based on previous studies cross-comparing the liver proteomes from curcumin-treated tumor-bearing rats/untreated tumor-bearing rats/normal rats, data from the literature were reviewed for 25 mitochondrial proteins of interest. Their role in lipid metabolism, heme biosynthesis, the electron transport chain, small molecule transport, mitochondrial dynamics, the tricarboxylic acid cycle, and protection against oxidative stress were analyzed in the context of both cancer and non-malignant liver diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Pouliquen

2024

Explor Dig Dis

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“…Gastrointestinal (GI) cancer is a prevalent and highly malignant tumor in clinical practice [1]. Stomach cancer, in particular, ranks third in terms of mortality due to its low survival rate, with 782,685 deaths reported in 2018 [2].…”

Section: Introductionmentioning

confidence: 99%

Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection

Chen,

Wang,

Zhao

et al. 2024

Micromachines

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Quickly and accurately completing endoscopic submucosal dissection (ESD) operations within narrow lumens is currently challenging because of the environment’s high flexibility, invisible collision, and natural tissue motion. This paper proposes a novel stereo visual servoing control for a dual-segment robotic endoscope (DSRE) for ESD surgery. Departing from conventional monocular-based methods, our DSRE leverages stereoscopic imaging to rapidly extract precise depth data, enabling quicker controller convergence and enhanced surgical accuracy. The system’s dual-segment configuration enables agile maneuverability around lesions, while its compliant structure ensures adaptability within the surgical environment. The implemented stereo visual servo controller uses image features for real-time feedback and dynamically updates gain coefficients, facilitating rapid convergence to the target. In visual servoing experiments, the controller demonstrated strong performance across various tasks. Even when subjected to unknown external forces, the controller maintained robust performance in target tracking. The feasibility and effectiveness of the DSRE were further verified through ex vivo experiments. We posit that this novel system holds significant potential for clinical application in ESD surgeries.

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Antibody-drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms

Taylor,

Lindorfer

2024

Blood

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Numerous antibody-drug conjugates (ADC) are being developed for cancer immunotherapy. Although several of these agents have demonstrated considerable clinical efficacy and have won FDA approval, in many instances they have been characterized by adverse side effects (ASE) which can be quite severe in a fraction of treated patients. The key hypothesis in this perspective is that many of the most serious ASE associated with the use of ADC in the treatment of cancer can be most readily explained and understood due to the inappropriate processing of these ADC via pathways normally followed for immune complex clearance, which include phagocytosis and trogocytosis. We review the key published basic science experiments and clinical observations that support this idea. We propose that it is the interaction of the ADC with Fc receptors expressed on off-target cells and tissues that can most readily explain ADC-mediated pathologies which therefore provides a rationale for the design of protocols to minimize ASE. We describe measurements that should help to identify those patients most likely to experience ASE due to ADC and we propose readily available treatments as well as therapies under development for other indications that should substantially reduce ASE associated with ADC. Our focus will be on the following FDA-approved ADC for which there are substantial literatures: gemtuzumab ozogamicin (Mylotarg) and inotuzumab ozogamicin; and trastuzumab emtansine (T-DM1), and trastuzumab deruxtecan (T-DXd).

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Circulating tumour cells in gastrointestinal cancers: food for thought?

Cited by 5 publications

References 137 publications

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection

Antibody-drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms

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