Circulating Tumor DNA: A Potential Novel Diagnostic Approach in Gestational Trophoblastic Neoplasia

Bolze, Pierre‐Adrien; Slim, Rima

doi:10.1016/j.ebiom.2016.01.013

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Imaging tests such as ultrasound, pathological analysis, and elevated β-hCG analysis are essential to confirm the diagnostic suspicion of hydatidiform mole. At present, other biomarkers such as microRNA molecules or circulating tumor cells in peripheral blood are being investigated [6, 7].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Just an Acute Pulmonary Edema? Paraneoplastic Thyroid Storm Due to Invasive Mole

et al. 2022

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Hydatidiform mole is a malignant entity included in the gestational trophoblastic diseases. It usually produces pregnancy hormones such as beta-human chorionic gonadotropin (β-hCG), which in turn stimulates endogenous thyroid hormone production. We report the case of a high-risk complete invasive hydatidiform mole with pulmonary metastasis and associated paraneoplastic syndrome. The patient is a 30-year-old woman who presented symptoms of pregnancy and metrorrhagia. A uterine mass was detected. Urine β-hCG was found negative. In serum, 2,662,000 mIU/mL (normal range: <5) was found, together with parameters of severe hyperthyroidism. The patient underwent uterine curettage with diagnostic and therapeutic means. At that precise moment, her pregnancy-like symptoms worsened and she developed restlessness, tachycardia, diaphoresis, dyspnea at rest, and peripheral edema. A scan showed bilateral pulmonary nodules suggestive of metastasis, acute pulmonary edema, and bilateral pleural effusion without signs of pulmonary thromboembolism. At that time, she presented a free T4 of 2.34 ng/dL (normal range: 0.8–1.8 ng/dL), causing a thyroid storm with secondary cardiac dysfunction. The patient was treated with corticosteroid therapy to decrease peripheral conversion of thyroid hormone T4 to active T3. Her symptoms remitted within 8 h. After 48 h, T4 level was 1.2 ng/dL while serum β-hCG was 80,000 mIU/mL, with a positive urine result. The change in the urine analysis is due to the “hook effect” of the reactive test. An effective chemotherapy treatment was started according to the EMA-CO scheme, remaining free of disease at present. Knowing paraneoplastic syndromes is necessary to achieve the best clinical management and to start treatment early.

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Section: Discussion/conclusionmentioning

confidence: 99%

Just an Acute Pulmonary Edema? Paraneoplastic Thyroid Storm Due to Invasive Mole

et al. 2022

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“…[6,7] Some scientists reported that circulating tumor DNA could be detected through simple blood samples and determined the source of HCG-related tumors, which could help doctors diagnose malignant trophoblastic disease early and determine FIGO classifications to guide the selection of chemotherapy. [6,29]…”

Section: Discussionmentioning

confidence: 99%

Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism

Yang

Li²

2017

Medicine

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“…However, only the gestational choriocarcinoma has DNA of paternal origin in its genome. Indeed, in childbearing women, the gestational choriocarcinoma is differentiated from the (non-gestational) germ-cell subtype, by detecting the presence of paternal DNA in tumoral cells [10 , 11] . Consequently, gestational choriocarcinoma is a unique neoplasm in its genetic background.…”

Section: Focus On Gestational Choriocarcinomamentioning

confidence: 99%

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

Frega¹,

Kepp²,

Turchetti³

et al. 2021

Translational Oncology

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The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.

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Circulating Tumor DNA: A Potential Novel Diagnostic Approach in Gestational Trophoblastic Neoplasia

Cited by 4 publications

References 9 publications

Just an Acute Pulmonary Edema? Paraneoplastic Thyroid Storm Due to Invasive Mole

Just an Acute Pulmonary Edema? Paraneoplastic Thyroid Storm Due to Invasive Mole

Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

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