Circulating Thrombomodulin Levels Are Related to Latent Progression of Atherosclerosis in Hypertensive Patients.

Dohi, Yasuaki; Ohashi, Masahiro; Sugiyama, Masaya; Takase, Hiroyuki; Sato, Koichi; Ueda, Ryuzo

doi:10.1291/hypres.26.479

Cited by 27 publications

(22 citation statements)

References 26 publications

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“…Serum creatinine concentration is considered to correlate with oxidative stress, 21 endothelial dysfunction 22 and more progressive atherosclerosis. 23,24 These biological abnormalities may also contribute to the excessive cardiovascular risk. Moreover, cardiac death from heart failure was significantly more common in the elevated serum creatinine group in the present study.…”

Section: Discussionmentioning

confidence: 99%

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Yamaguchi

Kasanuki

Ishii

et al. 2007

Circ J

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Background Data about the long-term mortality of acute myocardial infarction (AMI) patients with renal insufficiency who received sufficient early revascularization are scant, so the present study evaluated the impact of serum creatinine levels on the long-term mortality in patients with AMI undergoing successful primary percutaneous coronary intervention (PCI). Methods and ResultsThe Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) registry has 3,021 consecutive AMI patients. Primary PCI was attempted in 1,451 patients and successful revascularization was obtained in 1,359 patients (93.6%). An elevated serum creatinine level, defined as creatinine ≥1.2 mg/dl, was observed in 216 patients (15.8%). Univariate analyses showed statistical differences between normal and elevated serum creatinine groups in age, gender, hypertension, previous myocardial infarction, number of diseased vessels and Killip class. During a median follow-up period of 39 [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] months, the event-free survival rate was lower in elevated creatinine group than normal creatinine group. Multivariate Cox proportional hazards model showed that serum creatinine level was an independent predictor of long-term mortality (adjusted hazard ratio 1.43 [95% confidence interval 1.03-1.99]). Conclusion The serum creatinine level on admission in patients with AMI predicts long-term mortality, even in those with successful primary PCI. (Circ J 2007; 71: 1354 -1359

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Section: Discussionmentioning

confidence: 99%

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Yamaguchi

Kasanuki

Ishii

et al. 2007

Circ J

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“…The degree of atherosclerosis in the retinal vessels (stage 1-4 according to Scheie) was determined by examination [6,11].…”

Section: Methodsmentioning

confidence: 99%

Oxidative Stress, Inflammation, and Atherosclerotic Changes in Retinal Arteries in the Japanese Population; Results from the Mima Study

et al. 2008

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Abstract. Oxidative stress and inflammation are known to play roles in the pathogenesis of vascular events. The aim of this study was to investigate the relationship between oxidative stress, inflammation, and atherosclerosis in the general population. A population-based, cross-sectional study was made of 282 people (126 men and 156 women, mean age; 65 ± 13, mean BMI; 25.4 ± 2.7 kg/m 2 ) recruited from the Mima study in Tokushima Prefecture. Risk factors included age, sex, body mass index (BMI), cigarette smoking, systolic and diastolic pressure, fasting blood glucose, serum lipids, and high-sensitive C-reactive protein (hs-CRP). Oxidative stress in blood samples was measured by the diacron reactive oxygen metabolites (ROMs) test. The degree of sclerotic change was determined from fundus photographs according to Scheie's classification. After adjustment for age and sex, ROM levels positively correlated with hs-CRP levels, but not with ghrelin, leptin and adiponectin levels. Furthermore, ROM and hs-CRP levels positively and individually correlated with the grade of sclerotic change in the fundus oculi independent of age in a multiple regression analysis. These results suggest that oxidative stress and chronic inflammation promote atherosclerosis in the retinal arteries in the general population.

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“…In disease conditions, a higher or increasing plasma concentration is caused by increased proteolytic activity resulting in the cleavage of endothelial TM. In pathologic conditions, a high soluble TM may reflect the degree of endothelial damage [15,20]. Impaired kidney or hepatic function can further elevate its concentration [8].…”

Section: Tm and Endothelial Dysfunctionmentioning

confidence: 99%

Thrombomodulin and Endothelial Dysfunction: A Disease-Modifier Shared between Malignant Hypertension and Atypical Hemolytic Uremic Syndrome

Demeulenaere

Devreese

Vanbelleghem

et al. 2018

Nephron

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Thrombomodulin (TM) is an endothelial glycoprotein that is present in all blood vessels. Five percent of all patients with atypical hemolytic uremic syndrome (aHUS) have mutations in the gene coding for TM, with a peak presentation in young children. Mutations often translate into quantitative and qualitative abnormalities of this endothelial glycoprotein. Outcome of the TM-associated aHUS is relatively poor with frequent relapses after transplantation despite its membrane-bound character. We observed a woman presenting with malignant hypertension (MHT) and associated kidney, brain, cardiac, and hematological involvement with thrombotic microangiopathy on kidney biopsy. She had a documented mutation of the gene coding for TM, which was associated with both aHUS and an increased risk for venous and arterial thrombosis. As TM has anti-coagulant, anti-inflammatory, and cytoprotective properties and also attenuates alternative complement activation, this glycoprotein could play an active role in other diseases with endothelial involvement apart from aHUS. We discuss the potential role of TM in the pathophysiology of various endotheliopathies including MHT. We also provide a framework for future therapeutic options.

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Circulating Thrombomodulin Levels Are Related to Latent Progression of Atherosclerosis in Hypertensive Patients.

Cited by 27 publications

References 26 publications

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Oxidative Stress, Inflammation, and Atherosclerotic Changes in Retinal Arteries in the Japanese Population; Results from the Mima Study

Thrombomodulin and Endothelial Dysfunction: A Disease-Modifier Shared between Malignant Hypertension and Atypical Hemolytic Uremic Syndrome

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