Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes

Gardner, Kirby P.; Aldakkak, Mohammed; Tang, Cha‐Mei; Tsai, Susan; Adams, Daniel L.

doi:10.1038/s41698-021-00161-8

Cited by 18 publications

(39 citation statements)

References 24 publications

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“…In this study, high expression of CXCR4 on CAMLs and EMTs was prognostic of progression and worsened overall survival of PC patients. This suggests that CAMLs may be an excellent prognostic tool in PC and appear to coincide with previous publications on CAMLs in PC as it relates to progression and survival [9,10,24]. As high CXCR4 expression in CAMLs appeared to correspond with more CAMLs in circulation (Fig 3B ), and previous publications on CAMLs in PC found that higher numbers of CAMLs in circulation was predictive of progression [9].…”

Section: Plos Onesupporting

confidence: 89%

“…This suggests that CAMLs may be an excellent prognostic tool in PC and appear to coincide with previous publications on CAMLs in PC as it relates to progression and survival [9,10,24]. As high CXCR4 expression in CAMLs appeared to correspond with more CAMLs in circulation (Fig 3B ), and previous publications on CAMLs in PC found that higher numbers of CAMLs in circulation was predictive of progression [9]. The data in this study suggests that high expressions of CXCR4 in CAMLs can also stratify progression and survival (Fig 4C and 4D).…”

Section: Plos Onesupporting

confidence: 88%

“…Recently, a second type of tumor associated cell has been discovered, the cancer associated macrophage-like cell (CAML). This cell has been described as a pro-tumorigenic giant myeloid cell found in circulation, along with CTCs in several solid tumor cancers, including PC [6][7][8][9][10]. CAMLs have been shown to reliably predict progression and survival in PC, which may also be related to CTC intravasation into circulation [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…This cell has been described as a pro-tumorigenic giant myeloid cell found in circulation, along with CTCs in several solid tumor cancers, including PC [6][7][8][9][10]. CAMLs have been shown to reliably predict progression and survival in PC, which may also be related to CTC intravasation into circulation [8][9][10][11]. Another circulating tumor associated cell (TAC), that has been implicated in the progression of PC, is the epithelial-mesenchymal transition cell (EMT) [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer

et al. 2022

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The aggressive nature and metastatic potential of pancreatic cancer (PC) results in poor prognosis and high mortality. A better understanding of the underlying biology of PC and the ability of tumor cells to spread to distant sites is needed to advance the treatment of PC. The chemokine receptor CXCR4 has been heavily implicated in the spread and mobility of many solid cancers based on its role in cancer cell chemotaxis as well as increased metastatic potential. To better elucidate CXCR4’s role in the metastatic spread of PC, we examined its expression on various tumor associated cells (TACs) in the peripheral blood of PC patients, including circulating tumor cells (CTCs), epithelial to mesenchymal transition cells (EMTs), and cancer associated macrophage-like cells (CAMLs). In this pilot study, blood samples were procured from 30 PC patients prior to the start of therapeutic intent. CXCR4 expression was analyzed on TACs captured from the blood samples and evaluated in relation to cell migration as well as patient clinical outcomes. In total, CTCs, EMTs, and CAMLs were found in 27%, 60%, and 97% of PC patients, respectively. High CXCR4 expression in CTCs, CAMLs, and EMTs was found to significantly relate to their increased numbers in circulation. Further, higher expression of CXCR4 in CAMLs and EMTs was significantly related to faster progression and worse survival. These data suggest that CXCR4 expression in PC is strongly related to the intravasation and presence of TACs into circulation, as well as being a possible biomarker for aggressive metastatic disease.

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Section: Plos Onesupporting

confidence: 89%

Section: Plos Onesupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer

et al. 2022

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“…A recent study examined circulating stromal cells, cancer-associated macrophagelike cells (CAMLs) in addition to CTCs in PDAC patients using CellSieve, a microfiltration device that isolates cells based on size exclusion [111]. Although 23% of PDAC patients had CTCs, 95% of patients had CAMLs.…”

Section: Prognosis and Recurrencementioning

confidence: 99%

Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells

Yeo

Bastian

Strauss

et al. 2022

IJMS

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Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type, characterized by a dismal prognosis due to late diagnosis, frequent metastases, and limited therapeutic response to standard chemotherapy. Circulating tumor cells (CTCs) are a rare subset of tumor cells found in the blood of cancer patients. CTCs has the potential utility for screening, early and definitive diagnosis, prognostic and predictive assessment, and offers the potential for personalized management. However, a gold-standard CTC detection and enrichment method remains elusive, hindering comprehensive comparisons between studies. In this review, we summarize data regarding the utility of CTCs at different stages of PDAC from early to metastatic disease and discuss the molecular profiling and culture of CTCs. The characterization of CTCs brings us closer to defining the specific CTC subpopulation responsible for metastasis with the potential to uncover new therapies and more effective management options for PDAC.

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Circulating tumour cells in gastrointestinal cancers: food for thought?

et al. 2023

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Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant metastases. Arising from different locations in the GI system, the majority of metastatic GI malignancies colonise the liver and the lungs. In this context, circulating tumour cells (CTCs) are playing a critical role in the formation of new metastases, and their presence in the blood of patients has been correlated with a poor outcome. In addition to their prognostic utility, prospective targeting of CTCs may represent a novel, yet ambitious strategy in the fight against metastasis. A better understanding of CTC biology, mechanistic underpinnings and weaknesses may facilitate the development of previously underappreciated anti-metastasis approaches. Here, along with related clinical studies, we outline a selection of the literature describing biological features of CTCs with an impact on their metastasis forming ability in different GI cancers.

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Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes

Cited by 18 publications

References 24 publications

CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer

CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer

Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells

Circulating tumour cells in gastrointestinal cancers: food for thought?

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