Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis

Can sTREM-1 predict septic shock & death in late-onset neonatal sepsis? A pilot study

“…They found much higher values of sTREM-1 in those individuals who died, 2053 AE 889 pg/mL, than those who survived and affirmed that a sTREM-1 cutoff value of 1100 pg/mL is a good predictor of survival. 20 The mean sTREM-1 values for the control subjects reported by their group were higher than those reported by Sarafidis and our team for infected neonates and were much higher than the results reported by Mazzucchelli et al 10,19 Interestingly, we had undetectable levels of sTREM-1 in roughly 61% of our subjects, even though all of them had strong clinical indicators of infection. Neither Sarafidis, Mazzucchelli or Adly reported how many subjects in their series had a sTREM-1 value below LOD.…”

“…Neither Sarafidis, Mazzucchelli or Adly reported how many subjects in their series had a sTREM-1 value below LOD. 10,19,20 We found that the infants who progressed to septic shock had significantly higher sTREM-1 levels than those with sepsis who did not develop shock. Irrespective of different sTREM-1 values, which could be the result of different study populations and the ELISA kits used, previous works are in general agreement with our findings, in the sense that sTREM-1 levels were higher in the sickest neonates, and higher values are associated with poor prognosis.…”

“…Irrespective of different sTREM-1 values, which could be the result of different study populations and the ELISA kits used, previous works are in general agreement with our findings, in the sense that sTREM-1 levels were higher in the sickest neonates, and higher values are associated with poor prognosis. 10,19,20 We speculate that the possibility of sTREM-1 differences in relation to genetic background should be explored in future trials.…”

TREM-1 Signaling Promotes Host Defense during the Early Stage of Infection with Highly Pathogenic Streptococcus suis

“…To date, more than 1,500 human infections have been reported worldwide (4). In addition, S. suis has also been identified as the third most common cause of community-acquired bacterial meningitis in Hong Kong and as the leading and second most common cause of adult meningitis in Vietnam and Thailand, respectively (3,7,8). S. suis is known to constitute a high risk of infection for occupationally exposed people (9)(10)(11), but it could also cause severe infection in people who lack contact with swine and pork-derived products (12,13).…”

High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice

“…Previous studies have shown that dynamic changes in TREM-1 expression are associated with the severity and prognosis of sepsis. [27][28][29] Inhibition of the TREM-1 pathway can reduce inflammatory responses without affecting pathogen clearance, and prolong the survival of animals following infection. 30,31) More importantly, levels of TREM-1 mRNA expression were negatively correlated with the severity of sepsis in human patients.…”