Circulating soluble adhesion molecules in inflammatory bowel disease

Patel, R. T.; Pall, A. A.; Adu, Dwomoa; Keighley, M. R. B.

doi:10.1097/00042737-199511000-00005

Cited by 73 publications

(33 citation statements)

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“…Several studies have already postulated increased sE-selectin plasma levels in active UC and CD, but not in inactive UC and CD in which sE-selectin levels predominate as is observed in healthy patients. 33,38,39 The coculture exhibited similar results to the Caco-2 monoculture and no sE-selectin was detected in the supernatants. Thus, the epithelial cells formed a substantial barrier, even under inflammatory conditions, that prevent sE-selectin inducing factors from diffusing to the endothelial cells.…”

Section: Discussionmentioning

confidence: 72%

The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro

Kasper¹,

Hermanns²,

Cavelius³

et al. 2016

IJN

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Section: Discussionmentioning

confidence: 72%

The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro

Kasper¹,

Hermanns²,

Cavelius³

et al. 2016

IJN

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“…British Journal of Cancer (1998) 77(5) Saag, 1996), and also in non-malignant acute (infectious) and chronic diseases, such as acute infectious mononucleosis (Furukawa et al, 1993), P. falciparum malaria (Hvidd et al, 1993), autoimmune and viral hepatitis (Zohrens et al, 1993), alcoholic liver cirrhosis (Zohrens et al, 1993), extrinsic allergic alveolitis (Shijubo et al, 1995), acute attacks of bronchial asthma (Kobayashi et al, 1994), inflammatory bowel disease (Patel et al, 1995), systemic lupus erythematosus (Mrowka and Sieberth, 1994), active multiple sclerosis (Sharief et al, 1993;Tsukada et al, 1993;Rieckmann et al, 1995), diabetes (Roep et al, 1994) and chronic renal failure .…”

Section: Discussionmentioning

confidence: 99%

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

Grothey¹,

Heistermann²,

Philippou³

et al. 1998

Br J Cancer

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Summary The expression of the intercellular adhesion molecule-1 (ICAM-1, CD54) seems to have an influence on the metastatic behaviour of tumour cells via immunological mechanisms. Recently, a soluble form of ICAM-1 was identified in physiological fluids. We analysed the serum levels of sICAM-1 in patients with non-small-cell lung cancer (NSCLC) and healthy individuals using a sandwich ELISA technique. Sera from 51 patients with NSCLC were tested for sICAM-1 (46 male, five female; age 38-81 years, median 64 years), 29 of whom presented with localized and 26 with metastatic disease. The control group consisted of 40 healthy individuals (20 smokers, 20 non-smokers). Immunohistochemical analysis of ICAM-1 in tumour cells was performed in 20 cases. Patients with NSCLC had significantly higher serum levels of sICAM-1 compared with healthy non-smokers (P = 0.00001) and smokers (P = 0.0328). Metastatic disease was associated with higher sICAM-1 than localized tumours (P = 0.0013). Only 11 out of 23 patients with localized NSCLC had sICAM-1 levels >300 ng ml-1, compared with 25 out of 28 patients with metastatic disease. Histological expression of ICAM-1 was positively correlated with serum sICAM-1 (P = 0.0399). No difference was observed between histological tumour types with regard to sICAM-1 or NSCLC expression of ICAM-1. In sequential analysis (13 patients), rising sICAM-1 levels predicted a short-term fatal outcome (P = 0.0054) but, overall, sICAM-1 levels did not correlate with prognosis. In the control group, smokers showed significantly higher levels than non-smokers (P = 0.0016). In contrast to patients with NSCLC, sICAM-1 in the control group was correlated to the leucocyte count (r = 0.580, P = 0.003). In conclusion, serum levels of sICAM-1 seem to be associated with tumour burden and histological expression of ICAM-1 in patients with NSCLC. However, the (patho-) physiological role of ICAM-1 in NSCLC remains to be determined.

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“…Several studies have shown higher sICAM-1 levels in the blood of patients with active UC as compared with patient with inactive UC or to control patients [74,117], and a longitudinal study showed that a decrease in disease activity induced by anti-infl ammatory treatment was accompanied by a decrease in plasma sICAM-1 [75].…”

Section: Is Icam-1 a Disease Activity Marker?mentioning

confidence: 99%

Intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis: Presence, visualization, and significance

Vainer

2005

Inflamm. res.

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The intensive research of recent years has suggested that the cause of ulcerative colitis (UC) involves a genetic predisposition to an uncontrolled or unbalanced immune response to luminal or epithelial antigens or against other external factors. Intercellular adhesion molecule-1 (ICAM-1) is pivotal for the influx of neutrophil granulocytes into colonic mucosa, and gene analyses have found polymorphisms in the gene encoding ICAM-1, indicating that changes in ICAM-1 function may be involved in the pathogenesis of UC. Clinical trials of the ICAM-1 antisense oligonucleotide Alicaforsen, which inhibits the synthesis of ICAM-1, have shown positive results in the treatment of patients with left-sided (distal) UC. In addition to emphasizing the central role of ICAM-1 in active stages of UC, the results provide hope for the development and introduction of a more specific and efficient treatment for UC than those currently available. This review discusses the results from studies on the expression of ICAM-1 in colonic tissue from patients with UC.

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Circulating soluble adhesion molecules in inflammatory bowel disease

Cited by 73 publications

References 0 publications

The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro

The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

Intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis: Presence, visualization, and significance

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