Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy

Blockade of Kinin B1receptor counteracts the depressive-like behavior and mechanical allodynia in ovariectomized mice

“…The reduction of estrogen levels has been associated with increased reactive oxygen species (ROS) [50][51][52]. In preclinical studies, the increase of ROS induced upregulation of B1R on the rat brain submitted to the insulin resistance model [47].…”

Estimation of tissue and crevicular fluid oxidative stress marker in premenopausal, perimenopausal and postmenopausal women with chronic periodontitis

“…The same authors also stated that the effect of oxidative stress periodontitis is more apparent in GCF; this may also explain why only GCF 8‐OHdG levels varied significant among the groups. Increased circulating oxidative stress and decrease in antioxidant defences have been documented in healthy women postmenopause partly because menopausal transition is associated with decline in oestrogen levels . Interestingly, the replacement of oestrogen through hormone therapy can reduce blood 8‐OHdG concentration …”

“…Increased circulating oxidative stress and decrease in antioxidant defences have been documented in healthy women postmenopause partly because menopausal transition is associated with decline in oestrogen levels. 29,[59][60][61][62] Interestingly, the replacement of oestrogen through hormone therapy can reduce blood 8-OHdG concentration. 36 Tissue levels of 8-OHdG did not show any overall significance among the three groups, and there are contradictory studies showing unchanged or decreased oxidative stress levels have been reported in women undergoing menopause naturally.…”

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

“…For example, increased levels of malondialdehyde (MDA), protein carbonyl and 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) have been reported to be biomarkers of OS in breast cancer compared to controls . Further, reduced antioxidant defense system consisting of nonenzyme glutathione (GSH) and enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and catalase (CAT) have been observed in breast cancer subjects compared to control ones …”