Circulating osteoprotegerin is associated with age and systolic blood pressure, but not with lipid profile or fasting glucose, in postmenopausal women

Uemura, Hirokazu; Miyatani, Yuka; Yamada, Masayo; Hiyoshi, Mineyoshi; Arisawa, Kokichi; Irahara, Minoru

doi:10.1097/gme.0b013e318046369b

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…The strong positive relation we found between age and OPG was previously described in men (17,26,27), elderly women (15,23), and diabetic subjects (27) and has been interpreted as a compensatory mechanism counteracting the age progression of bone resorption and atherosclerosis (16,17,19,28). This increase was also linked to the expected modifications in renal function observed with age.…”

Section: Discussionsupporting

confidence: 64%

“…Two recent studies in Japanese postmenopausal and Korean healthy women (20,23) did not find any relationship between these two parameters. Conversely, a recent study in obese subjects (24) reported lower serum OPG values in comparison with normal-weight controls; the authors explained this finding by a lower activity of osteoclast in obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the above findings, the relationship of OPG with body mass index (BMI), lipid profile, and insulin sensitivity has been the subject of few and controversial reports depending on the study population (20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

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Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Gannagé‐Yared¹,

Yaghi²,

Habre³

et al. 2008

European Journal of Endocrinology

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Objective: We analyzed the relation of osteoprotegerin (OPG) with insulin sensitivity, lipid profile, serum glutamic pyruvic transaminase (SGPT), adipocytokines, and C-reactive protein (CRP) in obese and non-obese subjects. Methods: In the study, 170 subjects (106 obese and 64 non-obese, sex ratio female/maleZ2.03) were included. Thirty-two obese subjects were reevaluated 6 months after the weight loss induced by bariatric surgery. Results: OPG did not differ between obese and non-obese subjects (respective mean values 5.17 and 4.96 pmol/l) or according to gender, but was positively correlated with age (P!0.0001 for both groups). OPG was statistically higher in 18 obese diabetic subjects compared with non-diabetics (PZ0.03). After adjustment for age, no significant correlation was found between OPG and body mass index (BMI), waist, systolic and diastolic blood pressure, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, leptin, and adiponectin in both the obese and non-obese subjects. However, OPG was positively correlated with homeostasis model assessment (HOMA) index and SGPT levels in obese subjects at baseline (rZ0.295, rZ0.20, P!0.05) and after adjustment for age (rZ 0.28, rZ0.20, P!0.05). OPG was also significantly correlated with CRP; this correlation persisted after adjustment for age in obese subjects (rZ0.30, P!0.01). In a multivariate analysis in the obese group, HOMA index and CRP were independent predictors of OPG while SGPT was not. Six months post-surgery, OPG did not change, despite a significant reduction in glucose, SGPT, cholesterol, triglycerides, CRP, and leptin values (PZ0.02, PZ0.006, PZ0.007, P!0.001, P!0.001, P!0.001 respectively) and a significant increase in adiponectin and HDL values (P!0.001 for both variables). Conclusion: Our results show that in obese subjects, OPG is not related to BMI. However, we describe new relationships between OPG and both HOMA index and CRP.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Gannagé‐Yared¹,

Yaghi²,

Habre³

et al. 2008

European Journal of Endocrinology

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“…Min H et al have demonstrated that subcutaneous administration of OPG to OPG-deficient mice prevented arterial calcification, thus they have proposed that OPG/ RANKL signaling pathway might have an important role in the regulation of both pathological and physiological calcification [12]. A positive correlation between OPG and atherosclerosis in postmenaposal women has also been reported [28]. Dovio A et al have shown higher levels of OPG among females with Cushing Syndrome, a group that is at increased risk for cardiovascular diseases; this suggests that OPG levels may be associated with a higher risk for coronary disease [29].…”

Section: Discussionmentioning

confidence: 84%

Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese children

et al. 2010

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AbstractOsteoprotegerin (OPG)/“receptor activator of nuclear factor kappa B-ligand” (RANKL) system has an important role in the remodeling of bone through regulation of osteoclastogenesis. We aimed to detect OPG and RANKL levels, particularly in obese children in the pubertal period and to investigate whether these parameters correlate with insulin resistance in childhood. Our study included 66 obese children ranging in age from 9.1 to 16 years, and 22 non-obese children ranging in age from 10.5 to 16 years. Blood glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured for all cases; HOMA-IR, Quicki index and atherogenic index were calculated. Serum OPG and RANKL levels were also measured. OPG and RANKL levels did not show any difference between obese and non-obese children (P>.05). No difference in these 2 parameters were observed among the children with and without insulin resistance (P>.05). No correlation could be established between the OPG, the HOMA-IR, Quick and atherogenic indices. Obesity and insulin resistance are believed to show their effect in the later period of life to become able to change some of the parameters.

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“…Furthermore, a correlation between insulin resistance and plasma OPG has been reported in obese subjects (21) and elderly men (22), whereas a study including only women showed no relationship (23). Three studies of associations between body mass index (BMI) and OPG did not show any relationships, but information about insulin or insulin sensitivity was not reported (23)(24)(25). In a few studies, the focus was on the relationship between markers of insulin resistance and OPG, and these found a correlation with C-reactive protein and TNF-a levels in men with type 2 diabetes (26), while serum OPG was found associated with carotid intima media thickness in women with previous gestational diabetes (27).…”

Section: Introductionmentioning

confidence: 99%

Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity

Jörgensen

Vind²,

Nybo³

et al. 2009

European Journal of Endocrinology

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Objective: Osteoprotegerin (OPG) is a soluble tumour necrosis factor-receptor-like molecule present in connective tissues, especially bone and vasculature. It is known to accumulate in the arterial wall in diabetes. As its synthesis in vascular cells is decreased by insulin, we wanted to elucidate the acute effects of insulin on plasma OPG concentrations in individuals with type 2 diabetes and obese individuals compared with lean controls. Design: The study population consisted of ten type 2 diabetic, ten obese subjects, and ten lean subjects with no family history of diabetes. Methods: All subjects underwent a 4-h euglycemic-hyperinsulinemic clamp. Plasma OPG, insulin, lactate, HbA1c, cholesterol, triglycerides, free fatty acids (FFA), and glucose disposal rate were measured before and at the end of the clamp. Results: Baseline OPG concentrations did not differ significantly between groups. Insulin infusion decreased plasma OPG concentrations in all groups (P!0.01); however, the fall in OPG was 50% less in obese and type 2 diabetic individuals (PZ0.007). Baseline OPG correlated with fasting insulin, baseline lactate, and low density lipoprotein cholesterol in the diabetic group, and with baseline FFA in the lean group. The relative change of OPG in response to insulin correlated inversely with HbA1c and baseline FFA in the lean group. Conclusions: Acute hyperinsulinemia decreases plasma OPG, but with diminished effect in individuals with type 2 diabetes and obesity. Increased levels of OPG in arteries and plasma in diabetes together with the capability of plasma OPG as a cardiovascular risk predictor may be related to the described effects of insulin.European Journal of Endocrinology 161 95-101

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Circulating osteoprotegerin is associated with age and systolic blood pressure, but not with lipid profile or fasting glucose, in postmenopausal women

Abstract: These results suggest that increased circulating OPG in postmenopausal women is closely related to higher systolic blood pressure, which could cause atherosclerosis.

Cited by 16 publications

References 32 publications

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese children

Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity

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