Circulating Osteoprotegerin and Soluble RANK Ligand in Systemic Sclerosis

Dovio, Andrea; Data, Valeria; Carignola, R.; Calzolari, G; Vitetta, Rosetta; Ventura, Massimo; Saba, L.; Severino, Adriana; Angeli, A

doi:10.3899/jrheum.080192

Cited by 29 publications

(32 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their remarkable findings confirm the results of our work, to our knowledge the first controlled study to demonstrate an increased prevalence of hypovitaminosis D in SSc 3 . The renewed interest in vitamin D in autoimmune diseases gives us the opportunity to show previously unpublished data and make some observations about this issue.…”

Section: Hypovitaminosis D In Systemic Sclerosissupporting

confidence: 91%

See 1 more Smart Citation

Hypovitaminosis D in Systemic Sclerosis

et al. 2009

Self Cite

View full text Add to dashboard Cite

Section: Hypovitaminosis D In Systemic Sclerosissupporting

confidence: 91%

“…Our study comprised 60 patients and 60 matched controls 3 . 25OHD levels were lower in patients than in controls [median 23 ng/ml (range 3-92) and 39 ng/ml (14-138), respectively; p < 0.001] even after matching for season of sampling.…”

Section: Hypovitaminosis D In Systemic Sclerosismentioning

confidence: 99%

Hypovitaminosis D in Systemic Sclerosis

et al. 2009

Self Cite

View full text Add to dashboard Cite

“…The patients in that study included both fertile and postmenopausal women. Higher sRANKL levels and sRANKL/OPG ratio were found in patients with SSc and Turk et al . pointed out that TNF‐α has a strong association with the osteoclastogenic mediator RNKL, and an inverse association with BMD, in patients with Crohn's disease (a kind of inflammatory bowel disease caused by abnormal autoimmune status) .…”

Section: Discussionmentioning

confidence: 93%

The association between systemic sclerosis and bone mineral density- a meta-analysis of observational studies

et al. 2014

View full text Add to dashboard Cite

Previous research has shown inconsistent effect of systemic sclerosis (SSc) on bone mineral density (BMD). The objective of this study was to perform a meta-analysis of previous articles to investigate the differences in BMD (g/cm(2) ) between SSc and non-SSc populations and to discuss potential underlying mechanisms. Twelve full-text articles (including an outlier study and two studies with identical data) with 662 SSc patients and 886 controls were identified by searching Medline prior to 10 September, 2013 using search terms 'Systemic sclerosis' OR 'scleroderma' and 'osteoporosis' OR 'bone density' OR 'bone mass'. BMD (mean and standard deviation), T-scores and Z-scores at lumbar spine, femoral neck and total hip measured by dual-energy X-ray absorptiometry were extracted. Meta-analysis showed that a lower level of BMD was found in SSc patients, with weighted mean difference of -0.343 (95% CI: -0.500 to -0.186) at femoral neck, -0.084 (95% CI: -0.110 to -0.057) at total hip and -0.104 (95% CI: -0.135 to -0.073) at the lumbar spine. We conclude that patients with SSc may have a lower BMD level than healthy controls.

show abstract

“…One study that included 60 SSc patients showed that circulating levels of osteoprotegerin, but not RANKL, were higher in those with calcinosis. The authors suggested that this probably represented an inadequate compensatory response of osteoprotegerin as an inhibitor of calcification [25]. Two case reports showed successful use of bisphosphonates for the treatment of calcinosis in SSc patients suggesting that impaired bone metabolism may play a role in the pathogenesis of calcinosis [26,27].…”

Section: Discussionmentioning

confidence: 99%

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Valenzuela

Baron

Herrick

et al. 2016

Seminars in Arthritis and Rheumatism

View full text Add to dashboard Cite

Objectives We sought to identify the clinical factors associated with calcinosis in an international multicenter collaborative effort with the Scleroderma Clinical Trials Consortium (SCTC). Methods This is a retrospective cohort study of 5218 patients with systemic sclerosis (SSc). Logistic regression was used to obtain odds ratios (OR) relating calcinosis to various clinical features in multivariate analyses. Results A total of 1290 patients (24.7%) had calcinosis. In univariate analyses, patients with calcinosis were older than patients without calcinosis, more likely to be female, and had longer disease duration from the first non-Raynaud phenomenon symptom. Patients with calcinosis were more likely to have digital ulcers, telangiectasias, acro-osteolysis, cardiac disease, pulmonary hypertension, gastrointestinal involvement, arthritis, and osteoporosis, but less likely to have muscle disease. Anti-Scl-70, RNA-polymerase-III, and U1-RNP autoantibodies were significantly less common in patients with calcinosis, while anticentromere (ACA), anti-PM/Scl, and anticardiolipin antibodies were more frequent. In multivariate analysis, the strongest associations with calcinosis were digital ulcers (OR = 3.9; 95% CI: 2.7–5.5; p < 0.0001) and osteoporosis (OR = 4.2; 95% CI: 2.3–7.9; p < 0.0001). Conclusion One quarter of patients with SSc have calcinosis at some time during their illness. Our data confirm a strong association of calcinosis with digital ulcers, and support a novel association with osteoporosis.

show abstract

Circulating Osteoprotegerin and Soluble RANK Ligand in Systemic Sclerosis

Cited by 29 publications

References 40 publications

Hypovitaminosis D in Systemic Sclerosis

Hypovitaminosis D in Systemic Sclerosis

The association between systemic sclerosis and bone mineral density- a meta-analysis of observational studies

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

Contact Info

Product

Resources

About