Hypovitaminosis D in Systemic Sclerosis

Calzolari, G; Data, Valeria; Carignola, R.; Angeli, Alberto

doi:10.3899/jrheum.090439

Cited by 32 publications

(47 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the 25OHD levels and frequencies of 25OHD deficiency observed in our trial were comparable to the 25OHD data from patients with SSc studied in sun-rich countries 1,2,3,4,5,6,7 . Hence, 25OHD deficiency in patients with SSc is probably not dependent on the geographic location 5 .…”

Section: To the Editorsupporting

confidence: 58%

Significantly Decreased Serum 25-Hydroxyvitamin D Levels in a Large German Systemic Sclerosis Cohort

Gambichler¹,

Chrobok²,

Höxtermann³

et al. 2011

J Rheumatol

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 58%

Significantly Decreased Serum 25-Hydroxyvitamin D Levels in a Large German Systemic Sclerosis Cohort

Gambichler¹,

Chrobok²,

Höxtermann³

et al. 2011

J Rheumatol

View full text Add to dashboard Cite

“…In SSc patients, vitamin D deficiency was identified to be frequent and associated with disease activity or phenotype characteristics such as pulmonary hypertension, lung involvement, and extensive cutaneous forms (2)(3)(4)(5)(6)(7)(8). Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis, which is related to vitamin D receptor (VDR) ubiquitous distribution (9).…”

Section: Introductionmentioning

confidence: 99%

Low vitamin D status in systemic sclerosis and the impact on disease phenotype

et al. 2016

View full text Add to dashboard Cite

Objective: Vitamin D has pleiotropic effects including immunomodulatory, cardioprotective, and antifibrotic properties and is thus able to modulate the three main links in scleroderma pathogenesis. The aim of the study was to evaluate the level of vitamin D in patients with systemic sclerosis and to analyze the associations between the concentration of vitamin D and the features of systemic sclerosis.Material and Methods: Fifty-one consecutive patients were evaluated for visceral involvement, immunological profile, activity, severity scores, and quality of life. The vitamin D status was evaluated by measuring the 25hydroxy-hydroxyvitamin D serum levels. Results:The mean vitamin D level was 17.06±9.13 ng/dL. Only 9.8% of the patients had optimal vitamin D levels; 66.66% of them had insufficient 25(OH)D levels, while 23.52% had deficient levels. No correlation was found between vitamin D concentration and age, sex, autoantibody profile, extent of skin involvement, or vitamin D supplementation. Vitamin D levels were correlated with the diffusing capacity of the lung for carbon monoxide (p=0.019, r=0.353), diastolic dysfunction (p=0.033, r=−0.318), digital contractures (p=0.036, r=−0.298), and muscle weakness (p=0.015, r=−0.377) and had a trend for negative correlation with pulmonary hypertension (p=0.053, r=−0.29).Conclusion: Low levels of vitamin D are very common in systemic sclerosis. Poor vitamin status seems to be related with a more aggressive disease with multivisceral and severe organ involvement, especially pulmonary and cardiac involvement.

show abstract

“…Immune system dysfunction and extracellular matrix deposition are the main pathogenetic steps underlying the hallmarks of disease. Few studies have looked into this question, concluding both matrix deposition and immune dysfunction might be vitamin D-related [25,[27][28][29].…”

Section: Discussionmentioning

confidence: 99%

“…Controversial findings about the association between Body Mass Index (BMI) and hypovitaminosis D was reported [11,16,17,24,25].…”

Section: Discussionmentioning

confidence: 99%