Circulating monocytes in acute pancreatitis

Liu, Shiyu; Szatmary, Peter; Lin, Jing-wen; Wang, Qiqi; Chen, Lu; Liu, Tingting; Huang, Wei; Xia, Qing

doi:10.3389/fimmu.2022.1062849

Cited by 4 publications

(7 citation statements)

References 187 publications

(222 reference statements)

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“…In COVID-19, virus particles themselves act as pathogen-associated molecular patterns (PAMPs), which could also be identified by PRRs and activate local inflammation and an innate immune response, evoking the cytokine storm and assembling those induced by DAMPs [ 29 , 39 ]. Activated circulating leukocytes, particularly monocytes, are then recruited to the inflamed pancreas or infected lungs, provoking systemic inflammation and organ failure in AP and COVID-19 alike [ 29 , 40 , 41 , 42 , 43 ]. Moreover, monocytes/macrophages could be infected by SARS-CoV-2, triggering massive inflammatory responses in COVID-19 [ 44 ].…”

Section: Pathogenesis and Immunopathology In Ap And Covid-19mentioning

confidence: 99%

Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

Liu

Luo

Szatmary

et al. 2023

IJMS

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Acute pancreatitis is a common gastrointestinal disease with increasing incidence worldwide. COVID-19 is a potentially life-threatening contagious disease spread throughout the world, caused by severe acute respiratory syndrome coronavirus 2. More severe forms of both diseases exhibit commonalities with dysregulated immune responses resulting in amplified inflammation and susceptibility to infection. Human leucocyte antigen (HLA)-DR, expressed on antigen-presenting cells, acts as an indicator of immune function. Research advances have highlighted the predictive values of monocytic HLA-DR (mHLA-DR) expression for disease severity and infectious complications in both acute pancreatitis and COVID-19 patients. While the regulatory mechanism of altered mHLA-DR expression remains unclear, HLA-DR−/low monocytic myeloid-derived suppressor cells are potent drivers of immunosuppression and poor outcomes in these diseases. Future studies with mHLA-DR-guided enrollment or targeted immunotherapy are warranted in more severe cases of patients with acute pancreatitis and COVID-19.

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Section: Pathogenesis and Immunopathology In Ap And Covid-19mentioning

confidence: 99%

Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

Liu

Luo

Szatmary

et al. 2023

IJMS

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“…Classical monocytes exit the BM in a CCR2-dependent manner. CCL2 and CCL7 are ligands for CCR2 and contribute to the maintenance of stable concentrations of circulating monocytes [84].…”

Section: Additional Factors Affecting Myelopoiesis In Obesitymentioning

confidence: 99%

“…The spleen is the main site of extramedullary monocytopoiesis and contains a reserve of over one million monocytes. A general population of monocytes has been found to exist in the BM and in the spleen to generate monocytes and monocyte-derived macrophages [84].…”

Section: Additional Factors Affecting Myelopoiesis In Obesitymentioning

confidence: 99%

“…Monocytes are divided into classical (CM, CD14++CD16-−) [4,6], non-classical (NCM, CD14dimCD16+) (or CD14+CD16++ [84]), and intermediate (IM, CD14+CD16+ HLA-DR+CD86+CD11c+) (and CD14++CD16+) [86]. Classical and intermediate populations of monocytes are sensitive to CCL2, CCL3, and CCL4, while non-classical monocytes are sensitive to CX3CL1 [85,87].…”

Section: Monocytes 81 Characteristics Of Monocytes In Metabolic Syndr...mentioning

confidence: 99%

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Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

Todosenko,

Khaziakhmatova,

Malashchenko

et al. 2023

IJMS

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Monocytes play a key role in the development of metabolic syndrome, and especially obesity. Given the complex features of their development from progenitor cells, whose regulation is mediated by their interactions with bone marrow adipocytes, the importance of a detailed study of the heterogeneous composition of monocytes at the molecular and systemic levels becomes clear. Research argues for monocytes as indicators of changes in the body’s metabolism and the possibility of developing therapeutic strategies to combat obesity and components of metabolic syndrome based on manipulations of the monocyte compound of the immune response. An in-depth study of the heterogeneity of bone-marrow-derived monocytes and adipocytes could provide answers to many questions about the pathogenesis of obesity and reveal their therapeutic potential.

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“…The uncontrolled activation of inflammatory signals and the intense release of inflammatory cytokines resulted in the severity of the patients 15 . Researchers have found that inflammation can spread from the local pancreas to nearby tissues, or cause systemic inflammation through the cascade activation of cytokines 16–18 . In this context, We retrospectively analyzed the data of 12 serum cytokines at admission of 307 patients with AP, and further evaluated their relationship with AP severity and early complications.…”

Section: Introductionmentioning

confidence: 99%

The relationship between inflammatory cytokines and in‐hospital complications of acute pancreatitis

Yao,

Zhang,

Zhou

et al. 2024

Immunity Inflam & Disease

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ObjectiveAcute necrotic collection (ANC), acute peripancreatic fluid collection (APFC), pleural effusion, and ascites are common early complications of acute pancreatitis. This study aimed to investigate the relationship between 12 serum cytokines and the early complications and severity of acute pancreatitis (AP).MethodsWe retrospectively analyzed the clinical data of 307 patients with AP, and divided them into severe group and mild‐to‐moderate group according to the revised Atlanta classification. Propensity score matching was used to control for confounding factors. Binary logistic regression analysis was used to explore the relationship between cytokine levels and early complications of AP.ResultsSerum levels of interleukin (IL)‐1β, IL‐5, IL‐6, IL‐8, IL‐10, IL‐17, and tumor necrosis factor‐α were significantly higher in the severe acute pancreatitis (SAP) group than in the non‐SAP group (p < .05). After adjusting for confounding factors, the upper quartiles of IL‐6, IL‐8, and IL‐10 were associated with an increased risk of ANC compared with those in the lowest quartile (IL‐6: quartile 3, odds ratio [OR] = 3.99, 95% confidence interval [CI] = 1.95–8.16; IL‐8: quartile 4, OR = 2.47, 95% CI = 1.27–4.84; IL‐10: quartile 2, OR = 2.22, 95% CI = 1.09–4.56). APFC was associated with high serum levels of IL‐6 (quartile 3, OR = 1.32, 95% CI = 1.02–1.72), pleural effusions were associated with high serum levels of IL‐1β, IL‐6, IL‐8, and IL‐10 (IL‐1β: quartile 4, OR = 2.36, 95% CI = 1.21–4.58; IL‐6: quartile 3, OR = 4.67, 95% CI = 2.27–9.61; IL‐8: quartile 3, OR = 2.95, 95% CI = 1.51–5.79; IL‐10: quartile 4, OR = 3.20, 95% CI = 1.61–6.36), and high serum levels of IL‐6 and IL‐10 were associated with an increased risk of ascites (IL‐6: quartile 3, OR = 3.01, 95% CI = 1.42–6.37; IL‐10: quartile 3, OR = 2.57, 95% CI = 1.23–5.37).ConclusionSerum cytokine levels, including IL‐1β, IL‐6, IL‐8, and IL‐10 may be associated with the occurrence of early complications of AP. In daily clinical practice, IL‐6 may be the most worthwhile cytokine to be detected.

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Circulating monocytes in acute pancreatitis

Cited by 4 publications

References 187 publications

Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

The relationship between inflammatory cytokines and in‐hospital complications of acute pancreatitis

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