Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer

Du, Mulong; Shi, Danni; Lin, Yuan; Li, Pengchao; Chu, Haiyan; Qin, Chao; Chen, Yin; Zhang, Zhengdong; Wang, Meilin

doi:10.1038/srep10437

Cited by 106 publications

(90 citation statements)

References 41 publications

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“…[29] Only one study observed miR-455 significantly down-regulated in HCC tissue and serum in HCC related to type I glycogen storage disease. [30] The different up-regulation patterns of miR-130a and miR-505 in other solid tumors (bladder, [31] breast, [32] gastric, [33] ovarian, [34] colorectal [35] and non-small cell lung cancers [36] ) provide further evidence for their potential as HCC specific biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

Shen

Siegel

Remotti

et al. 2016

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Aim Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate “HCC tumor type specific” and “tumor common” miRNA panels Methods The authors integrate and analyze clinical, etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas (TCGA) and HCC data from Columbia University Medical Center (CUMC). Results Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues (over 2-fold changes) after Bonferroni correction for multiple comparisons, and most (28 miRNAs) were down-regulated in HCC tumors. Using this panel, the authors well classified HCC tumor tissues with 4 misclassifications among 48 paired tissues. Validating this panel in an additional 302 HCC tumor tissues, the authors almost perfectly distinguished tumor from non-tumor tissues with only two misclassifications (99% of HCC tissues correctly classified). Evaluating miRNA profiles in 32 independent HCC paired tissues from CUMC, the authors observed 40 miRNAs significantly deregulated in HCC with over 2-fold changes; 14 overlapped with those identified in TCGA. Subgroup analyses by HCC etiology found that 4 upregulated and 8 downregulated miRNAs were significantly associated with alcohol-related HCC. There were 7 and 4 miRNAs significantly associated with hepatitis B virus- and hepatitis C virus-related HCC, respectively. Data for the first time revealed that miR-24-1, miR-130a and miR-505 were significantly down-regulated only in HCC tumors; miR-142 and miR-455 were significantly down-regulated in HCC, but up-regulated in 5 other solid tumors; suggesting their HCC “tumor type specific” characteristics. A panel of 8 miRNAs was significant in at least 5 tumor types, including HCC, and was identified as “tumor common” marker. Conclusion The authors concluded that aberrant miRNA panels have HCC “tumor type specificity” and may be affected by etiologic factors.

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Section: Discussionmentioning

confidence: 99%

Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

Shen

Siegel

Remotti

et al. 2016

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“…In line with these notions, their participation in the TCC progression has been widely reported1819202122232425. For example, Jin et al .…”

Section: Discussionmentioning

confidence: 82%

MicroRNA-3713 regulates bladder cell invasion via MMP9

Wang

et al. 2016

Sci Rep

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Transitional cell carcinoma (TCC) is the most common type of bladder cancer but its carcinogenesis remains not completely elucidated. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TCC, whereas a role of miR-3713 in the pathogenesis of TCC has not been appreciated. Here, we reported that significantly higher levels of matrix metallopeptidase 9 (MMP9), and significantly lower levels of miR-3713 were detected in TCC tissue, compared to the adjacent non-tumor tissue, and were inversely correlated. Moreover, the low miR-3713 levels in TCC specimens were associated with poor survival of the patients. In vitro, overexpression of miR-3713 significantly decreased cell invasion, and depletion of miR-3713 increased cell invasion in TCC cells. The effects of miR-3713 on TCC cell growth appeared to result from its modification of MMP9 levels, in which miR-3713 was found to bind to the 3′-UTR of MMP9 mRNA to inhibit its protein translation in TCC cells. This study highlights miR-3713 as a previously unrecognized factor that controls TCC invasiveness, which may be important for developing innovative therapeutic targets for TCC treatment.

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“…MiR-99a-5p was significantly down-regulated in bladder cancer tissues, and the lower expression of miR-99a was correlated with the more aggressive phenotypes of bladder cancer. Moreover, miR-99a-5p was also decreased in plasma and urine supernatants of bladder cancer patients [24,26,27]. Besides the diagnostic value, miR99a-5p was a predictive marker of OS of bladder cancer by both of studies based on clinical samples and TCGA resource [17,28].…”

Section: Discussionmentioning

confidence: 85%

“…In cellular component and molecular function, the processes most strongly enriched were endomembrane system and transcription regulator activity relatively R [20][21][22][23]. Furthermore, miR-1-3p was reported to be decreased in the plasma of bladder cancer patients, as compared to healthy controls, which increased the chances for miR-1-3p to be a non-invasive biomarker for the early detection of bladder cancer [24]. The restoration of miR-1-3p in vitro could induce cell apoptosis in bladder cancer cell lines [20,25].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues

Wei

et al. 2016

Tumor Biol.

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There has been accumulative evidence that microRNAs (miRNAs) play essential roles in the tumorigenesis and progression of bladder cancer. However, individual studies and small sample size caused discrepant outcomes. Thus, the current study focused on a comprehensive profiling of all differentially expressed miRNAs in a total of 519 bladder cancer tissue samples, based on miRNA microarray data. Altogether, 11 prioritized miRNAs stated by 21 published microarray datasets, including five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b) and six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171) were analyzed with vote-counting strategy and a Robust Rank Aggregation method. Subsequently, miRNA in silico target prediction and potential pathway enrichment analysis were performed to investigate the prospective molecular mechanism of miRNAs in the tumorigenesis of bladder cancer. We found that most of the relative pathways of the aberrantly expressed miRNAs found in the current study were closely correlated with different biological processes, cellular components, molecular functions, cancer pathogeneses, and some cell signalings, such as Wnt signaling, insulin/IGF, PI3 kinase, and FGF signaling pathways. Hence, a comprehensive overview on the miRNA expression pattern in bladder cancer tissues was gained by the current study. These miRNAs might be involved in the tumorigenesis and deterioration of bladder cancer.

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Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer

Cited by 106 publications

References 41 publications

Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

MicroRNA-3713 regulates bladder cell invasion via MMP9

Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues

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