MicroRNA-3713 regulates bladder cell invasion via MMP9

Wu, Wenbo; Wang, Wei; Du, Yuchen; Li, Hao; Xia, Shujie; Liu, Haitao

doi:10.1038/srep32374

Cited by 10 publications

(10 citation statements)

References 33 publications

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“…MMP9 activity has been shown to be higher in invasive bladder cancer compared to normal control 58 . Knockdown of MMP9 by microRNAs in bladder cancer cells also resulted in decreased cell invasion 59 . However, the prognostic significance of MMP9 has not yet been fully elucidated.…”

Section: Discussionmentioning

confidence: 96%

Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer

Wong¹,

Wei²,

Lyu³

et al. 2017

Int. J. Biol. Sci.

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Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive. In this study, we have shown that expression of OPN was significantly higher in bladder cancer specimens with higher T-stage or tumor grades. In addition, a high level of OPN was significantly associated with poorer survival in two independent bladder cancer patient cohorts totaling 389 bladder cancer patients with available survival data. We further identified Matrix metallopeptidase 9 (MMP9) and S100 calcium-binding protein A8 (S100A8) were both downstream factors for OPN in bladder cancer specimens and bladder cancer cell lines. Expression of OPN was significantly positively associated with that of MMP9 and S100A8, while overexpression of OPN resulted in upregulation of MMP9 and S100A8, and knockdown of OPN showed consistent downregulation of MMP9 and S100A8 expression levels. Importantly, expression levels of both MMP9 and S100A8 were significantly associated with higher T-stage, higher tumor grade and a shorter survival time in the bladder cancer patients. Interestingly, OPN expression only predicted survival in MMP9-high, but not MMP9-low subgroups, and in S100A8-low but not S100A8-high subgroups. Our results suggest that OPN, MMP9 and S100A8 all play a significant role in bladder cancer progression and are potential prognostic markers and therapeutic targets in bladder cancer. The mechanistic link between these three genes and bladder cancer progression warrants further investigation.

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Section: Discussionmentioning

confidence: 96%

Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer

Wong¹,

Wei²,

Lyu³

et al. 2017

Int. J. Biol. Sci.

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show abstract

“…Previous studies have demonstrated that miRNAs are involved in a number of cancer-associated biological processes, including cell proliferation, apoptosis, the cell cycle, invasion, migration and metastasis (13)(14)(15). Notably, miRNA dysregulation has been reported in the majority of types of human cancer, including bladder cancer (16), prostate cancer (17), glioma (18), gastric cancer (19) and osteosarcoma (20). Previous studies have revealed that abnormally expressed miRNAs may be correlated with tumorigenesis and tumor development (21,22).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1

Xie

Zhang

et al. 2017

Molecular Medicine Reports

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Colorectal cancer (CRC) is the most frequently diagnosed malignancy of the gastrointestinal tract. The dysregulation of microRNAs (miRNAs/miRs) has been reported in the majority of types of human cancer, and is correlated with tumorigenesis and tumor development. Abnormal expression of miR‑663 has been observed in various types of human cancer. However, little is known about its role in CRC. Therefore, the aim of the present study was to clarify the expression and potential role of miR‑663, and its underlying molecular mechanism in CRC. It was observed that miR‑663 was markedly downregulated in CRC tissues and cell lines. Decreased miR‑663 expression levels in CRC tissues were correlated with tumor, node, metastasis stage and lymph node metastasis. Functional assays revealed that upregulation of miR‑663 inhibited cell proliferation and invasion in CRC. Further molecular mechanism assays demonstrated the fascin (FSCN1) was a target gene of miR‑663. In addition, FSCN1 was increased and negatively correlated with miR‑663 expression in CRC tissues. FSCN1 underexpression mimicked the tumor suppressive functions induced by miR‑663 overexpression on CRC cell proliferation and invasion. Collectively, the present study presented evidence that miR‑663 may act as a tumor suppressor in CRC by directly targeting FSCN1, which may lead to a potential therapeutic strategy focusing on miR‑663 and FSCN1 for patients with this disease.

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“…C-jun was an important oncogene that could provide signals for cell survival; it was highly overexpressed in various invasive cancers, and repression of c-jun was beneficial to inhibiting the development and progression of cancer [ 34 , 35 ]. MMP9 has been shown to be involved in the migration and invasion of various tumors, including breast cancer, transitional cell carcinoma, and non-small cell lung cancer [ 36 – 39 ]. A recent study revealed that epigenetic down-regulation of COL1A1 mRNA expression might have a role as a prognostic biomarker of hepatocellular carcinoma [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the key genes and pathways in enchondromas using a gene expression microarray

et al. 2017

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Enchondromas are the most common primary benign osseous neoplasms that occur in the medullary bone; they can undergo malignant transformation into chondrosarcoma. However, enchondromas are always undetected in patients, and the molecular mechanism is unclear. To identify key genes and pathways associated with the occurrence and development of enchondromas, we downloaded the gene expression dataset GSE22855 and obtained the differentially expressed genes (DEGs) by analyzing high-throughput gene expression in enchondromas. In total, 635 genes were identified as DEGs. Of these, 225 genes (35.43%) were up-regulated, and the remaining 410 genes (64.57%) were down-regulated. We identified the predominant gene ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were significantly over-represented in the enchondromas samples compared with the control samples. Subsequently the top 10 core genes were identified from the protein-protein interaction (PPI) network. The enrichment analyses of the genes mainly involved in two significant modules showed that the DEGs were principally related to ribosomes, protein digestion and absorption, ECM-receptor interaction, focal adhesion, amoebiasis and the PI3K-Akt signaling pathway.Together, these data elucidate the molecular mechanisms underlying the occurrence and development of enchondromas and provide promising candidates for therapeutic intervention and prognostic evaluation. However, further experimental studies are needed to confirm these results.

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MicroRNA-3713 regulates bladder cell invasion via MMP9

Cited by 10 publications

References 33 publications

Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer

Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer

MicroRNA-663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1

Exploring the key genes and pathways in enchondromas using a gene expression microarray

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