Circulating miR-192 and miR-193b Are Markers of Prediabetes and Are Modulated by an Exercise Intervention

Abstract

Our data show that the pattern of circulating miRNAs is modified by defects in glucose metabolism in a similar manner in mice and humans. This circulating miRNA signature for prediabetes could be used as a new diagnostic tool, as well as to monitor response to intervention.

Circulating microRNAs and diabetes: potential applications in medical practice

“…Surgical interventions such as kidney transplantation or simultaneous pancreas-kidney transplantation appear to partially normalise the deregulated miRNA profile observed in type 1 diabetic patients [37]. Furthermore, a partial normalisation of deregulated miRNAs (miR-126, -192, -193b) was also observed after lifestyle interventions in prediabetic type 2 patients [23,26], and this was concomitant with an improvement of glycaemic control [26]. These results suggest that miRNAs could be potential biomarkers of treatment efficacy.…”

“…Interestingly, for some miRNAs, such as miR-126 and miR23a, the difference was significantly greater in type 2 diabetic than in prediabetic individuals, suggesting that their levels could be correlated with the worsening of the glycaemic status [23,25]. Furthermore, in one study miR-192 and miR-193b were reported to be deregulated in the serum of prediabetic individuals but not in that of diabetic individuals, suggesting that prediabetic, diabetic and healthy individuals have distinct profiles [26]. Finally, altered miRNA expression (miR-15a, -29b, -126, -223, -28-3p) has been observed in serum from normoglycaemic individuals who developed type 2 diabetes over a 10 year period [27].…”

“…The observation of the deregulation of miRNA profiles in different biological fluids of diabetic patients compared with healthy controls was the first evidence supporting the idea that miRNAs could be biomarkers of the diabetic disease (Table 1). Indeed, a differential miRNA profile between type 2 diabetic patients and healthy controls was found in whole blood [20,21], serum [22][23][24][25][26], plasma [27][28][29][30][31][32][33] and plasma exosomes [34]. Studies revealed a different miRNA pattern in serum of type 1 diabetic patients compared with healthy individuals [35], as well as in plasma [36,37] and urine [36].…”

“…Several studies have identified age-related modifications in circulating miRNA levels [77][78][79][80][81][82]. Notably, among these, miR-29b [27,28,70], miR-130b [31], miR-222 [31], miR-375 [22], miR-21 [26,27,36] and miR-126 [23,27,30,31] were found to be deregulated in diabetic patients. These results underline that age could induce a bias, which has to be dealt with.…”

MicroRNAs: Marcadores séricos en diabetes mellitus tipo 2 y ejercicio físico

“…De manera muy interesante, 6 pre-diabéticos y 13 controles participaron en un protocolo de ejercicio supervisado y recomendaciones dietarias por 16 semanas. Al final de la intervención, los sujetos pre-diabéticos presentaban una disminución significativa de sus niveles séricos basales de miR-192 y miR-193b, llegando a ser comparables con los controles 31 . Ambos estudios, además de proponer un grupo de miRNAs (miRNA-126, miRNA-192, miRNA-193b) que son potenciales marcadores tempranos de DM2, demuestran un posible efecto del ejercicio físico sobre estas moléculas.…”