Effect of adipose‐derived exosome and exosomal miRNA on glycolipid metabolism

Abstract

Exosomes secreted by adipose tissue transfer miRNAs to insulin target tissues to regulate glycolipid metabolism. • MiRNAs have emerged as key factors of metabolic homeostasis via regulation of insulin signaling, lipolysis, and inflammation. • MiRNAs dysregulation in metabolic diseases, such as obesity, type 2 diabetes stresses their potential as therapeutic targets.

Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders

“…3 Interestingly, intercellular communication via EV-associated miRNAs is dysregulated in some pathologies such as metabolic disorders involving various tissues including liver or adipose tissue (AT). [4][5][6][7] In the present review, we have focused our attention on the functions of adipose tissue EV (ADEV)-derived miRNAs in different aspects of metabolic disorders such as type 2 diabetes (T2D) and obesity.…”

“…Among the biological signals, it has been shown that micro‐RNAs (miRNAs) are loaded into various EVs that convey miRNAs from their donor cells to the target cells in order to regulate gene expression 3 . Interestingly, intercellular communication via EV‐associated miRNAs is dysregulated in some pathologies such as metabolic disorders involving various tissues including liver or adipose tissue (AT) 4–7 . In the present review, we have focused our attention on the functions of adipose tissue EV (ADEV)‐derived miRNAs in different aspects of metabolic disorders such as type 2 diabetes (T2D) and obesity.…”