Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run

Abstract

These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.

The implications on clinical diagnostics of using microRNA-based biomarkers in exercise

“…Immediately after the acute bout of exercise, the levels of eight miRNAs (miR-106a, -221, -30b, -151-5p, let-7i, -146, -652 and -151-3p) were decreased, whereas five miRNAs (miR-338-3p, -330-3p, -223, -139-5p and -143) were increased 1 h after it. Three hours after the acute exercise, circulating levels of miR-1, -133a and -133b were increased, consistent with previous reports [67,69,70]. After 12 weeks of training, two miRNAs were increased (miR-103 and -107) and 11 were decreased, including miR-133a and -21 [75].…”

“…Mooren et al [69] showed that the levels of circulating miR-1, -133a, -206, -208b and -499 were increased after a marathon run. Accordingly, Gomes et al [67] verified increased levels of miR-1, -133a and -206 after a half-marathon race. In both studies, miR-206 had the highest increase compared with levels before the run.…”

“…While miR-126 is considered as a marker for endothelial damage [66], miR-133 was used as a muscle damage marker, something that has been suggested, but not confirmed [2,67,68]. Both miR-133 and -126 had increased levels in plasma of healthy individuals immediately after a marathon run and an increase only in miR-133 after a bout of resistance exercise.…”

“…Baggish et al [70] reported an increase of circulating miRNAs that are enriched in muscle (miR-1, -133a, -499), cardiac tissue (miR-208a), inflammation (miR-146a) and endothelial cells (miR-126) after a marathon race. Given that full marathon and half-marathon races are strenuous exercises and that circulating miR-133a may be an indicator of muscle damage [2], it has been proposed that raised levels of myomiRs may partly reflect the impact of exercise on muscle cells [66][67][68]. However, Mooren et al [69] observed only a moderate correlation between miR-133a and creatine kinase levels, the main indicator of skeletal muscle cell damage, whereas the response time course between the two were significantly different.…”

The Role of MicroRNAs in the Cardiac Response to Exercise

“…Conversely, Gomes et al (2014) found that circulating miR-1, -133, and -206 levels increased after a half-marathon. Mooren et al (2014) also showed that plasma levels of miR-1, -133, -206, -499, and -206 increased after running a marathon.…”