Circulating miR-1 as a potential predictor of left ventricular remodeling following acute ST-segment myocardial infarction using cardiac magnetic resonance

Abstract

Background: The identification of patients with a high likelihood of left ventricular (LV) remodeling with a high-risk prognosis has critical implications for risk stratification after acute ST-segment elevation myocardial infarction (STEMI). This study aimed to evaluate the relationship between circulating miR-1 and 6-month post-infarct LV remodeling based on cardiac magnetic resonance (CMR) imaging.Methods: A total of 80 patients with a first STEMI treated with primary percutaneous coronary intervention (PCI) who underwent CMR imaging 1 week and 6 months after STEMI were evaluated. The percentage changes of LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), LV end-systolic volume index (LVESV) at 1 week and 6 months after PCI (%ΔLVEF, %ΔLVEDV and %ΔLVESV) were calculated. miR-1 was measured using polymerase chain reaction (PCR)-based technologies in plasma samples that were collected at admission. The study group was divided into two groups based on a 10% cutoff value for the percentage of change in the LV end-diastolic volume (%ΔLVEDV): remodeling at high risk of major adverse cardiac events (MACEs) (%ΔLVEDV ≥10%, termed the LV remodeling group) and remodeling at lower risk of MACEs (%ΔLVEDV <10%, termed the non-LV remodeling group). The associations of miR-1 expression with the %ΔLVEDV, percentage change in the LV end-systolic volume (%ΔLVESV), and percentage change in the LV ejection fraction at follow-up were estimated.Results: Twenty-two patients (27.5%) showed adverse LV remodeling, and 58 patients (72.5%) did not show adverse LV remodeling at the 6-month follow-up of CMR. The mean LVEF, LVEDV index, and LVESV index values at 1 week were 50.6%±8.2%, 74.6±12.8 mL/m 2 , and 37.2±10.2 mL/m 2 , respectively.Mean LVEF at follow-up (53.5%±10.6%) was increased compared with baseline (P<0.001). There were significant decreases in LVEDV index and LVESV index values at follow-up (72.0±14.9 mL/m 2 and 33.7±11.0 mL/m 2 , respectively; P=0.009 and P<0.001, respectively). The expression of miR-1 at admission was positively correlated with the %ΔLVEDV (r=0.611, P<0.001) and %ΔLVESV (r=0.268, P=0.016).Receiver operating characteristic (ROC) analysis showed that miR-1 expression predicted LV remodeling with an area under the curve (AUC) value of 0.68 (95% CI: 0.56-0.78). Compared with the clinical factors of peak creatine kinase-myocardial band (CK-MB) and peak troponin T level, peak logNT-proBNP showed the highest predictive power, with an AUC value of 0.75 (95% CI: 0.64-0.84). A model including the clinical, CMR, and miR-1 factors showed greater predictive power (P=0.034) than a model including only clinical and CMR factors, with AUCs of 0.89 (95% CI: 0.80-0.95) and 0.81 (95% CI: 0.71-0.89), respectively.Conclusions: Circulating miR-1 at admission is an independent predictor of LV remodeling 6 months after STEMI. miR-1 showed incremental value in predicting LV remodeling compared with the clinical and CMR measurements.

Long non-coding RNA SENCR alleviates hypoxia/reoxygenation-induced cardiomyocyte apoptosis and inflammatory response by sponging miR-1

“…Recently, circulating miR-1 has been revealed to be upregulated and to have significant diagnostic and prognostic value in AMI (12). Another study also presented that the overexpression of circulating miR-1 can predict the occurrence of larger infarct size and more myocardial necrosis (13). The role of SENCR in AMI was studied in this study and its potential molecular mechanism among SENCR and circulating miR-1 was also declaimed.…”

MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling

“…miR-1 was recently proposed as a prognostic biomarker for post-MI LVR [ 87 ]. Ma and colleagues investigated 80 patients with first-time MI with ST-elevation.…”

MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications

“…LVR is a complex process involving cardiac myocyte growth and death, inflammation, fibrosis, and neovascularization [ 85 , 86 ]. Cardiomyocyte death occurs in the acute phase of STEMI, followed by subsequent recruitment of inflammatory cells to begin the repair process.…”

“…Grabmaier et al measured plasma levels of miR-1, miR-21, miR-29b and miR-92a on days 4 and 9 and 6 months after AMI in a group of 44 patients and in 18 matched controls [ 99 ]. miR-1 and miR-29b levels were significantly correlated with infarct volume changes at 6 months follow-up, while only miR-29b levels were associated with changes to left ventricular end-diastolic volume over time [ 85 , 99 ]. Quameni et al [ 85 ] proved that miR-1 at admission is an independent predictive factor of LVR after AMI and provides critical information for early therapeutic interventions for LVR after STEMI) [ 85 ].…”