Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases

Verma, Parmila; Pandey, Rajan Kumar; Prajapati, Priyanka; Prajapati, Vijay Kumar

doi:10.3389/fmicb.2016.01274

Cited by 83 publications

(76 citation statements)

References 48 publications

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“…Circulating miRNAs have been proven to serve as potential diagnostic biomarkers and prognostic factors in different types of diseases, including pathogen infection . Our data suggested that the elevated expression of miR‐28‐3p, miR‐143‐3p, miR‐151a‐3p, and miR‐148a‐3p were closely associated with H pylori infection.…”

Section: Discussionmentioning

confidence: 66%

Circulating microRNA signatures serve as potential diagnostic biomarkers for Helicobacter pylori infection

Zhang

et al. 2018

J of Cellular Biochemistry

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Helicobacter pylor (H pylori), a Gram‐negative, microaerobic human pathogen, has been found to be involved in many gastroduodenal diseases. Accurate diagnosis of H pylori infection is a vital part of the effective management of gastroduodenal diseases. Circulating microRNAs (miRNAs) have shown the potential to be used as noninvasive biomarkers for the diagnosis of infectious diseases. The aim of this study was to explore plasma miRNAs as noninvasive biomarkers for H pylori infection. We performed a plasma miRNA expression profile using Illumina high‐throughput sequencing and validated the levels of differentially expressed miRNAs in the plasma of 63 H pylori‐infected patients and 41 healthy volunteers by quantitative real‐time polymerase chain reaction (qRT‐PCR). The sequencing results showed that 37 miRNAs were upregulated in the H pylori‐infected patients compared with that in the healthy volunteers, while six miRNAs were downregulated. qRT‐PCR and receiver operator characteristic analysis suggested that the expression of miR‐28‐3p, miR‐143‐3p, miR‐151a‐3p, and miR‐148a‐3p were closely associated with H pylori infection. Therefore, the four plasma miRNA panels mentioned above could serve as promising noninvasive biomarkers of H pylori infection.

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Section: Discussionmentioning

confidence: 66%

Circulating microRNA signatures serve as potential diagnostic biomarkers for Helicobacter pylori infection

Zhang

et al. 2018

J of Cellular Biochemistry

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“…However, it is also true that host cell’s miRNAs may target viral mRNAs. In many cases, this bidirectional interference is resolved in favor of the viruses that as a result may escape the immune response and complete the replication cycle (for a review see Verma et al [116] and Piedade and Azevedo-Pereira [117]).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Catalanotto

Cogoni

Zardo

2016

IJMS

917

675

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The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the discovery and classification of several types of ncRNAs. Based on their precursor structures, biogenesis pathways and modes of action, ncRNAs are classified as small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs), promoter associate RNAs (pRNAs), small nucleolar RNAs (snoRNAs) and sno-derived RNAs. Among these, miRNAs appear as important cytoplasmic regulators of gene expression. miRNAs act as post-transcriptional regulators of their messenger RNA (mRNA) targets via mRNA degradation and/or translational repression. However, it is becoming evident that miRNAs also have specific nuclear functions. Among these, the most studied and debated activity is the miRNA-guided transcriptional control of gene expression. Although available data detail quite precisely the effectors of this activity, the mechanisms by which miRNAs identify their gene targets to control transcription are still a matter of debate. Here, we focus on nuclear functions of miRNAs and on alternative mechanisms of target recognition, at the promoter lavel, by miRNAs in carrying out transcriptional gene silencing.

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“…MicroRNAs are involved in regulating epigenetic networks within cells and via exosomes between cells (Vyas and Dhawan, 2016). They are increasingly recognized as to be critical for the outcome of diverse infectious diseases (Bettencourt et al, 2016; Das et al, 2016; Verma et al, 2016). Also, miRNAs appear to be critical for efficacy of vaccination (Corral-Fernández et al, 2016; Shim et al, 2016; Wang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

et al. 2017

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MicroRNAs are increasingly recognized as epigenetic regulators for outcome of diverse infectious diseases and vaccination efficacy, but little information referring to this exists for malaria. This study investigates possible effects of both protective vaccination and P. chabaudi malaria on the miRNome of the liver as an effector against blood-stage malaria using miRNA microarrays and quantitative PCR. Plasmodium chabaudi blood-stage malaria takes a lethal outcome in female Balb/c mice, but a self-healing course after immunization with a non-infectious blood-stage vaccine. The liver robustly expresses 71 miRNA species at varying levels, among which 65 miRNA species respond to malaria evidenced as steadily increasing or decreasing expressions reaching highest or lowest levels toward the end of the crisis phase on day 11 p.i. in lethal malaria. Protective vaccination does not affect constitutive miRNA expression, but leads to significant (p < 0.05) changes in the expression of 41 miRNA species, however evidenced only during crisis. In vaccination-induced self-healing infections, 18 miRNA-species are up- and 14 miRNA-species are down-regulated by more than 50% during crisis in relation to non-vaccinated mice. Vaccination-induced self-healing and survival of otherwise lethal infections of P. chabaudi activate epigenetic miRNA-regulated remodeling processes in the liver manifesting themselves during crisis. Especially, liver regeneration is accelerated as suggested by upregulation of let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, let-7f-5p, let-7g-5p, let-7i-5p, miR-26a, miR-122-5p, miR30a, miR27a, and mir-29a, whereas the up-regulated expression of miR-142-3p by more than 100% is compatible with the view of enhanced hepatic erythropoiesis, possibly at expense of megakaryopoiesis, during crisis of P. chabaudi blood-stage malaria.

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Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases

Cited by 83 publications

References 48 publications

Circulating microRNA signatures serve as potential diagnostic biomarkers for Helicobacter pylori infection

Circulating microRNA signatures serve as potential diagnostic biomarkers for Helicobacter pylori infection

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

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