Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia

Redman, C.W.G.; Sargent, Ian L.

doi:10.1016/j.placenta.2007.11.016

Cited by 221 publications

(185 citation statements)

References 45 publications

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“…In our investigation, the observation of increased signs of apoptosis and cell damage together with the presence of intracellular oedema (Figure 11) in the syncytial layer is in line with the concept that there is more syncytial debris ( Figure 13) shed into maternal space in preeclampsia [19], as apoptosis and cell damage proceeds the shedding of syncytial fragments into maternal lacunae or intervillous space. An increased release of syncytiotrophblasts microparticles (STBM) formed by plasma membrane blebbing during apoptosis are triggered in excess into the maternal circulation [20].…”

Section: Disscussionsupporting

confidence: 87%

Electron and Scanning Microscopic Observations on the Syncytiotrophoblast Microvillous Membrane Contribution to Preeclampsia in Early Placental Rats

Selim¹,

Elshmry²,

Rashed³

2013

J Blood Disord Transfus

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Section: Disscussionsupporting

confidence: 87%

Electron and Scanning Microscopic Observations on the Syncytiotrophoblast Microvillous Membrane Contribution to Preeclampsia in Early Placental Rats

Selim¹,

Elshmry²,

Rashed³

2013

J Blood Disord Transfus

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“…During pregnancy, serum lipoproteins except HDL-C increase considerably 17 and are two-to threetimes higher in PIH. Worldwide, various studies 5,[18][19][20][21][22][23][24] have reported elevated lipid levels in PIH subjects similar to our observations.…”

Section: Discussionmentioning

confidence: 94%

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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“…Both trigger endothelial dysfunction and severe preeclampsia (34,35). The placental ischemia, reperfusion and associated oxidative stress amplify apoptosis by rupture of syncytial architecture and promote the release into the maternal circulation of several components (syncytiotrophoblast membrane microparticles and an excess of antiangiogenic factors, such as sFlt-1) that stimulate the synthesis of inflammatory cytokines (36)(37)(38). This excessive inflammatory response causes endothelial dysfunction, increased vascular reactivity and coagulopathy that precede the development of symptomatic disease (39).…”

Section: Pathogenesismentioning

confidence: 99%

Acute kidney injury in pregnancy: a clinical challenge

Machado¹,

Figueiredo²,

Borges³

et al. 2011

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The incidence of acute kidney injury in pregnancy declined significantly over the second half of the 20th century; however, it is still associated with major maternal and perinatal morbidity and mortality. A set of systemic and renal physiological adaptive mechanisms occur during a normal gestation that will constrain several changes in laboratory parameters of renal function, electrolytes, fluid and acid-base balances. The diagnosis of acute kidney injury in pregnancy is based on the serum creatinine increase. The usual formulas for estimating glomerular filtration rate are not validated in this population. During the first trimester of gestation, acute kidney injury develops most often due to hyperemesis gravidarum or septic abortion. In the third trimester, the differential diagnosis is more challenging for the obstetrician and the nephrologist and comprises some pathologies that are reviewed in this article: preeclampsia/HELLP syndrome, acute fatty liver of pregnancy and thrombotic microangiopathies.

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Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia

Cited by 221 publications

References 45 publications

Electron and Scanning Microscopic Observations on the Syncytiotrophoblast Microvillous Membrane Contribution to Preeclampsia in Early Placental Rats

Electron and Scanning Microscopic Observations on the Syncytiotrophoblast Microvillous Membrane Contribution to Preeclampsia in Early Placental Rats

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Acute kidney injury in pregnancy: a clinical challenge

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